iPSC-Derived Corneal Endothelial Cells

Zhou, Qingjun; Li, Zongyi

doi:10.1007/164_2023_644

Handbook of Experimental Pharmacology

2023

DOI: 10.1007/164_2023_644

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iPSC-Derived Corneal Endothelial Cells

Qingjun Zhou

Zongyi Li

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2024

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“…Induced Pluripotent Stem Cells (iPSCs): iPSC technology involves reprogramming somatic cells, such as skin fibroblasts or peripheral blood cells, into a pluripotent state using defined factors (e.g., Oct4, Sox2, Klf4, c-Myc). These iPSCs can then be differentiated into CEC-like cells through stepwise induction protocols [90][91][92].…”

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confidence: 99%

Advancements in Bioengineering for Descemet Membrane Endothelial Keratoplasty (DMEK)

Zwingelberg,

Karabiyik,

Gehle

et al. 2024

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Corneal diseases are the third leading cause of blindness worldwide. There are numerous causes of corneal blindness, and the common treatment for this condition often involves corneal tissue transplantation, such as Descemet's Membrane Endothelial Keratoplasty (DMEK). DMEK has been established as the preferred surgical technique for the treatment of corneal endothelial disorders. The success of DMEK depends largely on the quality of the donor endothelial cells and the trans-plantation procedure. However, the scarcity of suitable donor tissue and the sensitivity of endo-thelial cells pose a major challenge. In recent years, tissue engineering has attracted attention as potential solutions to these problems. This review offers an outline of the current landscape of DMEK in the context of bioengineering, exploring various methodologies, advancements, and fu-ture prospects.

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confidence: 99%

Advancements in Bioengineering for Descemet Membrane Endothelial Keratoplasty (DMEK)

Zwingelberg,

Karabiyik,

Gehle

et al. 2024

Preprint

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iPSC-Derived Corneal Endothelial Cells

Cited by 1 publication

References 77 publications

Advancements in Bioengineering for Descemet Membrane Endothelial Keratoplasty (DMEK)

Advancements in Bioengineering for Descemet Membrane Endothelial Keratoplasty (DMEK)

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