Generation of hydroxyl radicals during benzene toxicity

Three weeks' exposure of rats to dearomatized white spirit modifies indices of oxidative stress in brain, kidney, and liver

“…An attractive approach to investigate aging [15] and neurotoxicity [16] is to study the induction of oxidative stress. There is considerable evidence for the induction of excess free radicals and ROS* generation by various neurotoxic aromatic solvents.…”

“…There is considerable evidence for the induction of excess free radicals and ROS* generation by various neurotoxic aromatic solvents. These compounds include benzene [16], toluene [17][18][19], xylenes [19][20][21], and styrene [22]. There is less evidence for the induction of oxidative stress by aliphatic organic solvents.…”

Exposure of mice to tobacco smoke attenuates the toxic effect of methamphetamine on dopamine systems

“…:eneration in the liver. These include aliphatic compounds, such as carbon tetrachloride, and aromatic solvents, such as benzene, toluene, styrene and xylenes [43,[62][63][64]. Several of these compounds also stimulate CNS production of ROS [43,64].…”

Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit

“…Its activity can be used as an index of rates of generation of reactive oxygen species (ROS), summated over a prolonged period. Previous work on aromatic solvents including toluene, benzene, xylenes, and styrene suggest that enhancement of rates of free radical generation may underlie some of the neurotoxicity of these compounds (Khan et al 1990;Trenga et al 1991;Mattia et al 1993a,b). Furthermore, we have found evidence of excess pro-oxidant activity in an earlier study involving extended inhalation of aliphatic white spirit (Lam et al 1994).…”