Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit

Bondy, Stephen C.; Lam, Henrik Rye; Østergaard, Grete; Guo, Shirley X.; Ladefoged, Ole

doi:10.1007/s002040050192

Cited by 20 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been a number of reports of neurochemical changes in the CNS following repeated exposure to white spirit (Bondy et al 1995, Lam et al 1992, 1995, 2000, Ostergaard et al 1993, Savolainen and Pfaffli 1982, Steensgaard et al 1996, but in the absence of any functional or pathological changes, the interpretation is unclear. At present, there is no animal model for persistent CNS effects of solvents (Bruckner and Warren 2001).…”

Section: Studies To Assess the Potential For Persistent Cns Effects Imentioning

confidence: 99%

Characterization of the toxicological hazards of hydrocarbon solvents

McKee

Adenuga

Carrillo

2015

Critical Reviews in Toxicology

View full text Add to dashboard Cite

Hydrocarbon solvents are liquid hydrocarbon fractions derived from petroleum processing streams, containing only carbon and hydrogen atoms, with carbon numbers ranging from approximately C5-C20 and boiling between approximately 35-370°C. Many of the hydrocarbon solvents have complex and variable compositions with constituents of 4 types, alkanes (normal paraffins, isoparaffins, and cycloparaffins) and aromatics (primarily alkylated one-and tworing species). Because of the compositional complexity, hydrocarbon solvents are now identified by a nomenclature ("the naming convention") that describes them in terms of physical/ chemical properties and compositional elements. Despite the compositional complexity, most hydrocarbon solvent constituents have similar toxicological properties, and the overall toxicological hazards can be characterized in generic terms. To facilitate hazard characterization, the solvents were divided into 9 groups (categories) of substances with similar physical and chemical properties. Hydrocarbon solvents can cause chemical pneumonitis if aspirated into the lung, and those that are volatile can cause acute CNS effects and/or ocular and respiratory irritation at exposure levels exceeding occupational recommendations. Otherwise, there are few toxicologically important effects. The exceptions, n-hexane and naphthalene, have unique toxicological properties, and those solvents containing constituents for which classification is required under the Globally Harmonized System (GHS) are differentiated by the substance names. Toxicological information from studies of representative substances was used to fulfill REACH registration requirements and to satisfy the needs of the OECD High Production Volume (HPV) initiative. As shown in the examples provided, the hazard characterization data can be used for hazard classification and for occupational exposure limit recommendations. Introduction Scope and purpose of the documentThe present document summarizes information on the physical/ chemical properties and toxicological hazards of hydrocarbon solvents and provides examples of the ways in which the information on hazard characterization can be used for hazard classification and to set occupational exposure limits. Many of the toxicological studies were published separately, but the results are summarized herein and referenced in the appendices.Hydrocarbon solvents are liquid hydrocarbon fractions that are primarily produced by the distillation of petroleum feed stocks or their synthetic analogs (e.g., Fischer-Tropsch derived materials), sometimes followed by additional processing steps such as solvent extraction, hydrodesulfurization, or hydrogenation. 1 Most hydrocarbon solvents are complex substances with variable compositions and are best described as UVCB 2 (unknown and variable composition) substances, but some are single constituent (mono-constituent) substances. The complex and variable nature of these solvents is the consequence of their manufacturing processes. In short, most hydroca...

show abstract

Section: Studies To Assess the Potential For Persistent Cns Effects Imentioning

confidence: 99%

Characterization of the toxicological hazards of hydrocarbon solvents

McKee

Adenuga

Carrillo

2015

Critical Reviews in Toxicology

View full text Add to dashboard Cite

show abstract

“…The current findings in the present study were similar to those previous observations showing that PAHs were associated with kidney stones but not failing kidney in American adults. Animal studies using Swiss mouse and rats in vitro also presented that PAHs could damage the kidney (Krajka-Kuźniak and Baer-Dubowska 2003 ; Roos 2002 ; Bondy et al 1995 ; Bowes and Ramos 1994 ). In other words, it is likely that PAHs could exacerbate kidney dysfunction but not necessarily lead to fatal events.…”

Section: Discussionmentioning

confidence: 99%

Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012

Shiue

2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons (PAH) were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols, and pesticides. Therefore, it was aimed to study the relationships of urinary PAH and adult digestive conditions using a large human sample in a national and population-based study in recent years. Data was retrieved from the US National Health and Nutrition Examination Surveys, 2011–2012 including demographics, self-reported health conditions, and urinary PAH. Statistical analyses included chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of 5560 American adults aged 20–80 and included in the statistical analysis, urinary 4-hydroxyphenanthrene was significantly associated with celiac disease (odds ratio (OR) 1.61, 95 % confidence interval (CI) 1.14–2.26, P = 0.009). In addition, urinary 2-hydroxyfluorene (OR 1.35, 95 % CI 1.02–1.78, P = 0.038), 3-hydroxyfluorene (OR 1.35, 95 % CI 1.07–1.70, P = 0.015), 1-hydroxyphenanthrene (OR 1.48, 95 % CI 1.08–2.03, P = 0.017), 1-hydroxypyrene (OR 1.36, 95 % CI 1.05–1.77, P = 0.023), and 2-hydroxynapthalene (OR 1.25, 95 % CI 1.00–1.58, P = 0.054) were significantly associated with kidney stones, although not necessarily failing kidney. There were no statistically significant associations observed in the relationship of urinary PAH and liver problems, although higher levels of PAHs were observed. Urinary PAHs are associated with adult digestive conditions, although the causality cannot be established. From the research perspective, longitudinal monitoring from observational studies and experimental research understanding mechanism would be suggested. Regulation of minimizing PAHs exposure might need to be considered in future health and environmental policies.

show abstract

“…Gamma Glutamyl Transpeptidase (GGT) activity in the exposed group was higher by 99.12% relative to the control group, suggesting liver associated damage in the exposed group (Hyder et al, 2013). The liver damage apparently resulted in response to reactive/free radical species produced during metabolism of the hydrocarbon constituents of the inhaled petroleum products vapours (Bondy et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria

Egbuonu¹,

Nkwazema²

2015

Research J. of Environmental Sciences

View full text Add to dashboard Cite

The health concerns for petroleum workers warranted this study in asymptomatic exposed (n=64) and control (n=64) ) in the exposed group was higher (p<0.05) than that in the control group (11.59±2.10 and 7.53±1.71 μmol LG 1 ) by 97.50 and 134.40%, respectively whereas the computed TB:CB ratio (1.30±1.62) was lower (p<0.05) than that in the control group (1.54±2.33) by 15.58%. Aside the AST:ALT ratio (1.39±1.26) that was lower (p<0.05) than that in the control (2.22±1.84) by 37.39%, the other observations in the exposed group for computed serum ALT:AST ratio (0.72±2.42), ALT:ALP ratio (0.83±2.33) and CB:TB ratio (0.77±2.72) were higher (p<0.05) than that in the control (0.45±3.45, 0.73±2.04 and 0.65±3.11) by 60.00, 13.70 and 18.46%, respectively. The study suggests dysfunctional liver and other organs, with the attendant health implications in the petroleum depot workers, highlighting the need for health caution and protection.

show abstract

Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit

Cited by 20 publications

References 27 publications

Characterization of the toxicological hazards of hydrocarbon solvents

Characterization of the toxicological hazards of hydrocarbon solvents

Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012

Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria

Contact Info

Product

Resources

About