Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration

Zhang, Haomiao; Moriyama, Yasushi; Ayukawa, Yasunori; Rakhmatia, Yunia Dwi; Tomita, Yoko; Yasunami, Noriyuki; Koyano, Kiyoshi

doi:10.1007/s10266-018-0376-z

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…In our previous study, PLGA membranes loaded with FS were implanted on rat calvaria to increase their ability to regenerate new bone formation, especially in the initial period of healing. However, we found that only minimal bone had formed underneath this membrane, and the PLGA membrane had almost degraded after 8 weeks of healing time [ 23 ]. Despite the necessity of a second-stage surgical procedure for membrane removal, TMs may overcome the limitations of degradable membranes.…”

Section: Discussionmentioning

confidence: 99%

“…PLGA membrane loaded with or without FS was fabricated as described in a previous report [ 23 ]. In short, to prepare a single-phase solution, 2.4 g of PLGA was dissolved in 3 ml dichloromethane.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous study has shown that fluvastatin (FS)-loaded degradable PLGA has the potential effect to enhance soft and hard tissue healing in the tibia of rats [ 23 ]. However, the study revealed only minimal bone formation in a critical size defect site of the rats.…”

Section: Introductionmentioning

confidence: 99%

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Titanium membrane layered between fluvastatin-loaded poly (lactic-co-glycolic) acid for guided bone regeneration

Furuhashi

Rakhmatia

Ayukawa

et al. 2022

Regenerative Biomaterials

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The aim of this study was to investigate titanium membranes (TMs) layered between poly (lactic-co-glycolic acid) (PLGA) containing fluvastatin for use in guided bone regeneration. Membranes consisting of PLGA, fluvastatin (FS)-containing PLGA (PLGA–FS), TM layered between PLGA (TM–PLGA), and TM layered between FS-containing PLGA (TM–PLGA–FS) were prepared, and their mechanical and chemical properties were evaluated. The TM groups showed statistically significant differences, in terms of tensile strength and elastic modulus, when compared to the PLGA groups. The release of FS was demonstrated to be higher in the TM–PLGA–FS group than the PLGA–FS group after day 14. The effect of membrane implantation on the calvaria of Wistar rats was measured using micro-computed tomography (micro-CT) and morphometrical analyses, as well as histological observations. At 4 weeks, the TM–PLGA–FS and TM–PLGA groups were found to have lower bone mineral density but higher bone formation, when compared to the control and PLGA groups. At 8 weeks, the use of TM–PLGA–FS membranes significantly enhanced bone formation in the calvaria model, compared to the other groups. These results suggest that a TM layered between PLGA containing FS potentially enhances bone formation, thus showing good potential as a GBR membrane.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Titanium membrane layered between fluvastatin-loaded poly (lactic-co-glycolic) acid for guided bone regeneration

Furuhashi

Rakhmatia

Ayukawa

et al. 2022

Regenerative Biomaterials

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“…By using fluvastatin-loaded PLGA membranes, Zhang and coworkers were able to show enhanced bone formation in both a rat calvarial and tibial defect model after 4 and 8 weeks. According to the authors, the PLGA membranes released fluvastatin with a release rate of approximately 1 µg/day [75]. Nevertheless, designed smart scaffolds potentially ought to comprise both natural and synthetic polymers to fulfill all requirements.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

et al. 2020

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Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above all diabetes mellitus and osteoporosis), chronic inflammation, and cancer. Adjuvant therapeutic agents such as recombinant growth factors, lipid mediators, antibiotics, antiphlogistics, and proangiogenics as well as other promising anti-resorptive and anabolic molecules contribute to improving bone healing in these disorders, especially when they are released in a targeted and controlled manner during crucial bone healing phases. In this regard, the development of smart biocompatible and biostable polymers such as implant coatings, scaffolds, or particle-based materials for drug release is crucial. Innovative chemical, physico- and biochemical approaches for controlled tailor-made degradation or the stimulus-responsive release of substances from these materials, and more, are advantageous. In this review, we discuss current developments, progress, but also pitfalls and setbacks of such approaches in supporting or controlling bone healing. The focus is on the critical evaluation of recent preclinical studies investigating different carrier systems, dual- or co-delivery systems as well as triggered- or targeted delivery systems for release of a panoply of drugs.

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“…Among them, Sr shows beneficial effects on bone cells and for bone formation in vivo and for osteogenic differentiation at low doses [44,45,46,47,48,49,50,51]. Another approach to provide occlusive GTR membranes with the ability to regenerate bone is the incorporation of growth factors, drugs or other biomolecules [5,52,53]. However, the physical adsorption of biomolecules on polymeric membranes has the drawbacks of low immobilization efficiency and fast desorption which make their covalent bonding on the polymer necessary [53].…”

Section: Introductionmentioning

confidence: 99%

Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications

Terzopoulou

Baciu

Gounari³

et al. 2019

Molecules

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Poly(ε-caprolactone) (PCL) is a bioresorbable synthetic polyester with numerous biomedical applications. PCL membranes show great potential in guided tissue regeneration because they are biocompatible, occlusive and space maintaining, but lack osteoconductivity. Therefore, two different types of mesoporous bioactive glasses (SiO2-CaO-P2O5 and SiO2-SrO-P2O5) were synthesized and incorporated in PCL thin membranes by spin coating. To enhance the osteogenic effect of resulting membranes, the bioglasses were loaded with the bisphosphonate drug ibandronate prior to their incorporation in the polymeric matrix. The effect of the composition of the bioglasses as well as the presence of absorbed ibandronate on the physicochemical, cell attachment and differentiation properties of the PCL membranes was evaluated. Both fillers led to a decrease of the crystallinity of PCL, along with an increase in its hydrophilicity and a noticeable increase in its bioactivity. Bioactivity was further increased in the presence of a Sr substituted bioglass loaded with ibandronate. The membranes exhibited excellent biocompatibility upon estimation of their cytotoxicity on Wharton’s Jelly Mesenchymal Stromal Cells (WJ-SCs), while they presented higher osteogenic potential in comparison with neat PCL after WJ-SCs induced differentiation towards bone cells, which was enhanced by a possible synergistic effect of Sr and ibandronate.

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Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration

Cited by 8 publications

References 22 publications

Titanium membrane layered between fluvastatin-loaded poly (lactic-co-glycolic) acid for guided bone regeneration

Titanium membrane layered between fluvastatin-loaded poly (lactic-co-glycolic) acid for guided bone regeneration

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications

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