Generalized Multinucleate Cell Angiohistiocytoma

Doane, Jennifer A.E.; Purdy, Kerri; Pasternak, Sylvia

doi:10.2310/7750.2014.14129

Cited by 7 publications

(8 citation statements)

References 11 publications

(31 reference statements)

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“…Vitiligo with anti‐thyroid antibodies in another patient, also anti‐Ro 60 and positive antinuclear antibodies were reported once . Primary biliary cholangitis, aortic and tricuspid valve replacements following endocarditis, diabetes and dyslipidemia were associated with MCAH in one patient . Also, the laboratory value of 17‐hydroxyprogesterone was elevated in one patient, and gastroesophageal reflux disease was reported in another .…”

Section: Literature Reviewmentioning

confidence: 90%

Generalized multinucleate cell angiohistiocytoma: case report and literature review

et al. 2016

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Section: Literature Reviewmentioning

confidence: 90%

Generalized multinucleate cell angiohistiocytoma: case report and literature review

et al. 2016

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“…Some of the papules may coalesce to form larger annular lesions. [1][2][3][4][5][6] The existing literature shows most MCAHs occur in middle-to old-aged persons, affecting women more than men. In this 14-year-old boy case, the authors confirmed that MCAH can also occur in young age patients.…”

Section: Discussionmentioning

confidence: 99%

“…Absence of clonality, several cases of spontaneous regression, and tendency to occur as multiple lesions usually at exposed areas vulnerable to trauma support the reactive condition hypothesis as being more plausible. 5 By comparing the microscopic and immunohistochemical findings of the papule (new lesion) and the plaque (old lesion), the authors could directly observe that the inflammatory response progresses during the course of MCAH.…”

Section: Discussionmentioning

confidence: 99%

A case of multinucleate cell angiohistiocytoma in a 14‐year‐old boy showing two different clinical and histopathological findings

et al. 2018

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Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red‐to‐brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. We report an exceptionally rare case of a 14‐year‐old boy who presented with multiple asymptomatic erythematous papules and a single flat brownish plaque on the left chest. The brownish plaque lesion histologically showed proliferation of dilated small vessels in the upper‐mid dermis and numerous oddly shaped multinucleate cells intermingled with lymphocytes and macrophages. The erythematous papules also showed dilated small vessels in the upper‐mid dermis and multiple interstitial histiocytic infiltrations, but no multinucleate cells were detected. In immunohistochemistry studies, CD68 and vimentin staining were positive for both specimens. Based on the clinicopathological findings and immunohistochemistry studies, MCAH was diagnosed. To the best of our knowledge, this is the first case report of MCAH occurring in young age and showing two different clinical and histological phases at the same time.

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“…11,15 The generalized variant is extremely rare, with only four cases recorded in the literature. Our patient present a localized form, with almost 40 lesions distributed exclusively on the lower limbs.…”

Section: Nevertheless the Immunochemistry For Eralpha Was Negative Inmentioning

confidence: 99%

Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH)

Coco

Guerriero

Stefani

et al. 2017

J Dermatol Case Rep

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Background: Multinucleated Cell Angiohistiocytoma (MCAH) is a rare disease, first described by Smith and Wilson Jones in 1985. Since then, less than 100 cases have been reported in the literature. Clinically it is characterized by papules or plaques arising from a specific anatomical area such as lower extremities, dorsum of the hands and face. Some generalized cases have been reported. Main observations:We report a case of 77-year-old woman who presented with multiple itching. reddish to violaceous, flat to domed-shaped plaques on the lower legs with symmetrical and bilateral distribution along the saphena veins. On dermoscopy examination only a red-violaceous homogeneous area was visible. Histology showed remarkable proliferation of dilated small vessels in the upper and mid dermis and bizarre-shaped multinucleate giant cells with scalloped cytoplasm that were intermingled with numerous mononucleated spindle cells. Many mast cells containing the characteristic granules were also detected, often adjacent to the multinucleate cells. Based on the clinico-pathologic findings the diagnosis of MCAH was established. Conclusions:To our knowledge, this is the first documented case of MCAH with a bilateral and linear pattern disposed on the lower limbs, following the saphena veins. In this patient chronic trauma induced by ambulation might have contributed to development of the lesions. (J Dermatol Case Rep. 2016; 10(4) MCAH is more frequent in elderly women than in men, suggesting that hormones can have a role in the pathogenesis of this entity. The typical clinical features consist of a cluster of red to violaceous papules or plaques, ranging in size from few millimetres to 1.5 cm, located on a single anatomical area as lower extremities, dorsum of the hands, wrists, fingers or face. The lesions can be arranged in an annular configuration or grouped in a cluster and are usually asymptomatic but may be rarely itchy. The clinical differential diagnoses may include dermatofibroma, angiofibroma, Kaposi sarcoma, pseudo-Kaposi sarcoma, granuloma anulare, lichen planus, pyogenic granuloma, giant-cell fibroblastoma, sarcoidosis and insect bite. Case ReportWe report a 77-year-old woman who presented with a 5-year history of multiple papules on the lower extremities. The patient reported that the first lesion appeared after a holiday and it was initially diagnosed as a mosquito bite. With time the lesion did not regress and new similar lesions occurred at the same site. Treatment with argon laser, performed by another institution, was unsuccessful. Physical examination showed multiple itching reddish to violaceous, flat to domed-shaped plaques on the lower legs with an unusual DOI: http://dx.doi.org/10.3315/jdcr.2016.1237 58 symmetrical and bilateral distribution along the saphena veins (Fig. 1). The overall lesions count was 38 and the size varied from 6 to 13 mm. Clinical diagnoses included Kaposi sarcoma, dermatofibroma and angiofibroma.On dermoscopy examination we observed no specific clues for the diagnosis. Only a...

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Generalized Multinucleate Cell Angiohistiocytoma

Abstract: Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.

Cited by 7 publications

References 11 publications

Generalized multinucleate cell angiohistiocytoma: case report and literature review

Generalized multinucleate cell angiohistiocytoma: case report and literature review

A case of multinucleate cell angiohistiocytoma in a 14‐year‐old boy showing two different clinical and histopathological findings

Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH)

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