Generalized melanosis caused by melanoma of the rectum

Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] (figure 1). His urine was dark brown in color when freshly voided.…”

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confidence: 99%

Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

Gambichler

Stücker

Kerner

et al. 2008

American Journal of Clinical Dermatology

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“…According to these clinical observations, 3 of our 4 patients died 1, 8 and 8 weeks, respectively, after the melanosis cutis had become first apparent. The clinical appearance can be variable from slate-blue to slate-gray [1,3,4]. In some cases, an accentuation of the melanosis in sun-exposed regions was reported [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…About 30 cases of generalized melanosis have been reported in the English literature so far [1]. Patients with melanosis cutis have a bleak prognosis with survival times of only weeks or months after the onset of melanosis [1,2].…”

Section: Introductionmentioning

confidence: 99%

Diffuse Melanosis cutis in Disseminated Malignant Melanoma

Hofmann¹,

Kiecker²,

Audring³

et al. 2004

Dermatology

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“…A colonoscopy study done for medical screening revealed colorectal melanosis in 491 of 32 140 individuals (1.53%). 8 Since melanosis is often found in noncutaneous melanoma patients, 9 AMM might be derived from melanocytes in the squamous epithelium of the anal canal. 10 In our patient, regional melanosis was detected next to the main tumor.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Endoscopic Ultrasonography and Magnetic Resonance Imaging for Anorectal Malignant Melanoma: Report of a Case

et al. 2003

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A 74-year-old Japanese woman presented with a 3-month history of anal bleeding. Proctoscopy revealed an unusual polypoid lesion with focal pigmentation at the dentate line, which was histologically diagnosed as a malignant melanoma. Whole-body clinical and radiographic evaluations revealed no alternative primary source. Endoscopic ultrasonography (EUS) showed well-delineated hypoechoic tumors invading the muscularis propria, and magnetic resonance imaging (MRI) revealed regional lymphadenopathy. Following this evaluation, an abdominoperineal resection with regional lymphadenectomy was performed. The excised tumor was histologically confirmed to be malignant melanoma, and its depth and metastatic lymph nodes proved to have been accurately and precisely evaluated by the preoperative examinations. Thus, EUS and MRI are useful preoperative diagnostic tools for the tumor staging of primary anorectal malignant melanomas, as for other rectal tumors.

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Generalized melanosis caused by melanoma of the rectum

Cited by 24 publications

References 20 publications

Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

Diffuse Melanosis cutis in Disseminated Malignant Melanoma

The Diagnostic Value of Endoscopic Ultrasonography and Magnetic Resonance Imaging for Anorectal Malignant Melanoma: Report of a Case

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