Generalized Lichen Spinulosus in a 4-Year-Old Boy Without Systemic Disease

An Uncommon Case of Lichen Spinulosus in an Adult Patient Clinically Mmimicking Folliculotropic Mycosis Fungoides

“…Topical keratolytics and emollients including salicylic acid, vitamin A, tretinoin, tacalcitol, adapalene, and urea are commonly used to treat LS [ 4 , 7 - 8 , 19 - 20 ]. If left untreated, the lesions may resolve on their own after a few weeks to months [ 10 ]. For patients with an underlying problem, treatment of the disease may improve LS [ 3 ].…”

An uncommon case of lichen spinulosus induced by dupilumab in a patient treated for bronchial asthma

“…6 Histopathology of a papule showed acanthosis, orthokera- LS is considered by some authors as a variant of keratosis pilaris (KP). 7 However, features supporting a separate disorder include the acute onset of well-circumscribed patches of hyperkeratotic papules lacking perilesional erythema, funnel-like orifice following removal of central keratotic spine, lack of AD association in some patient, absence of seasonal influence, and dermal inflammatory cell infiltrate on histology. 7 On the other hand, most histopathologic findings are indistinguishable between the 2 diseases and both are more frequently observed in AD patients, thus suggesting that LS and KP are different clinical presentation of the same condition.…”

“…7 On the other hand, most histopathologic findings are indistinguishable between the 2 diseases and both are more frequently observed in AD patients, thus suggesting that LS and KP are different clinical presentation of the same condition. 7 To date, KP occurrence has been reported in 2 asthma patients under treatment with dupilumab. 8 It has been hypothesized that dupilumab induces a transition of hair follicles from telogen phase to anagen phase, by increasing regulatory T lymphocyte activity.…”