Abstract:Acquired disorders of keratinization are a heterogeneous group of diseases, clinically characterized by dyskeratosis. This may involve a spectrum of presentations ranging from the soft velvety changes of acanthosis nigricans to the hard dry scaling of Flegel disease or the porokeratoses. The symptoms are often discrete, and while many of the diseases are poorly described, some show an association with other diseases, indicating the need for additional clinical investigations, e.g. the association between phryn… Show more
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