Generalized Granuloma Annulare As an Initial Manifestation of Chronic Myelomonocytic Leukemia: A Report of 2 Cases

Hinckley, Michael; Walsh, Sarah N.; Molnár, István; Sheehan, Daniel J.; Sangüeza, Omar P.; Yosipovitch, Gil

doi:10.1097/dad.0b013e318166ea1a

Cited by 29 publications

(15 citation statements)

References 16 publications

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“…The coexistent neoplasms included carcinomas, lymphomas, and acute myeloid leukemia, while separate manuscripts described additional cases of GA in patients with schwannoma, [12] visceral malignancy, [13] Hodgkin disease, [14] and chronic myelomonocytic leukemia. [15] While Li et al [11] found no definite relationship between GA and malignancy, they suggest the investigation of underlying malignancies particularly for older patients with skin lesions that histologically, but not necessarily clinically, resemble GA.…”

Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 97%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

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Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 97%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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“…Hematologic malignancies are the most frequently reported. Both Hodgkin [49][50][51][52][53][54] and non-Hodgkin 49,55-57 lymphoma and leukemias [58][59][60][61] have been reported in patients with GA. Solid tumors have also been reported, however, in association with GA.…”

Section: Systemic Associationsmentioning

confidence: 99%

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

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Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.

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“…Cutaneous presentations can vary and include recalcitrant dermatitis. 2 Several reports have described granulomatous dermatitis in the setting of underlying malignant conditions, including lymphoma, 3,4 leukemia, [5][6][7][8] and various solid organ malignancies.…”

Section: Commentmentioning

confidence: 99%