Generalized eruptive histiocytoma: report of a case and electron microscopic finding of Michaelis-Gutmann bodies

Abstract

Summary A 67‐year‐old woman with generalized eruptive histiocytoma since 1973 and type IV hyperlipidaemia, which was corrected by diet alone, is presented. Michaelis‐Gutmann (MG) bodies, usually characteristic but not specific for malakoplakia, were identified and confirmed ultrastructurally in one earlier biopsy but not in the subsequent skin lesions. This case differs clinically and pathologically from xanthomas secondary to type IV hyperlipidaemia, and malakoplakia of the skin. The pathogenesis of the MG bodies in this case is unknown.

Generalized Eruptive Histiocytoma: Report of a Pediatric Case

“…Their enzyme histochemical studies revealed lysosomal enzyme activities (3) such as acid phosphatase, nonspecific esterase, nucleoside triphosphatase, leucine aminopeptidase and succinic dehydrogenase activities in the proliferating cells. Electron microscopic observations revealed that the proliferating cells in GEH do not contain Langerhans' granules (4)(5)(6)(7)(8), but they showed granular structures lined by a double membrane (4), lysosome activity-related structures such as laminated bodies and dense bodies (5), annular structures, myeloid bodies and vacuoles (7), and comma shaped bodies (8). In the present study, we did not perform electron microscopic study, but lack of 5-100 immunoreactivity (9) was compatible with the classical concept of GEH as benign non-X histiocytic proliferation (4, 5).…”

Generalized eruptive histiocytoma: a report of a variant case showing the presence of dermal indeterminate cells

“…Pa|)ules and small coniluciU plac|ues than 20 cases (1-9) of this rare syndrome have been reported. Among them, some patients had minor differences such as grouping of the lesions (4,5), positivity for lipid (4,6) or PAS stain (7) in the histiocytic cells, and the presence of inflammatory infiltration such as eosinophils (1) as well as lymphocytes (1)(2)(3)8,9) or multinucleated giant cells (8).…”