Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia

Klemke, Claus‐Detlev; Dippel, Edgar; Geilen, Christoph C.; Koenigsmann, Michael; Thiel, Eckhard; Orfanos, Constantin E.; Goerdt, Sergij

doi:10.1016/s0190-9622(03)00037-9

Cited by 26 publications

(18 citation statements)

References 31 publications

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“…Thus, the capacity for elastolysis and elastophagocytosis may depend on the differentiation status of the macrophages involved. This was also demonstrated in a patient developing atypical generalised eruptive histiocytosis with pronounced elastophagocytosis in the course of acute myeloid leukaemia [15]. While AEGCG normally can be differentiated from GA by the different type of matrix degradation, i.e.…”

mentioning

confidence: 69%

Generalised Annular Elastolytic Giant Cell Granuloma

Klemke¹,

Siebold²,

Dippel³

et al. 2003

Dermatology

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mentioning

confidence: 69%

Generalised Annular Elastolytic Giant Cell Granuloma

Klemke¹,

Siebold²,

Dippel³

et al. 2003

Dermatology

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“…However, when a revision ofthe literature was made, some examples of GEH where lesions coalesce (6-9) could be found. Two of these patients presented with an underlying haematological neoplasm (6,7). Our patient was evaluated carefully for this possibility, but all the laboratory investigations were within normal ranges.…”

Section: Discussionmentioning

confidence: 93%

“…Clinically, it is characterized by recurrent crops of asymptomatic, small, firm, tan to reddish papules, symmetrically distributed over the face, trunk and proximal limbs, whicb may involute spontaneously, leaving macular pigmentation. Mucous membrane lesions are rare and visceral involvement bas not been observed, although tbere are some reports where an association with rheumatic fever (2), exanthema subituiTi (3) or an underlying neoplasm was noted (4)(5)(6)(7). Histological examination shows a monomorpbous proliferation of benign histiocytes without deposition of lipids.…”

mentioning

confidence: 99%

A Case of Generalized Eruptive Histiocytosis

Fernández-Jorge¹,

Goday-Buján²,

Losada³

et al. 2007

Acta Derm Venereol

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Histiocytoses are a heterogeneous group of diseases, characterized by the accumulation of reactive or neoplastic histiocytes in various tissues. Generalized eruptive histiocytosis belongs to cutaneous non-Langerhans' cell histiocytoses and is a rare, generalized, self-healing disorder that usually follows a benign clinical course. Herein, we report a case of generalized eruptive histiocytosis in a 41-year-old woman with peculiar clinical and histological features. Clinically, the papules showed a marked distribution into the seborrhoeic areas of the trunk, with a great tendency to coalesce. Furthermore, immunohistochemical labelling demonstrated that the histiocytes were positive for CD68, but negative for CD34, S100, CD1a and XIIIa factor. This is the second report of generalized eruptive histiocytosis with a negative XIIIa factor. We discuss the differential diagnoses of the clinical picture and emphasize that this benign cutaneous disorder should be subjected to close follow-up, owing to the possibility of evolution to a more severe type of histiocytosis or the association with underlying diseases. Spontaneous regression was observed in this actual case.

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“…[8] GEH may rarely be associated with underlying hematological malignancies like acute monocytic leukemia. [9] The features in this case which favored the diagnosis of GEH include age of the patient (adult), presence of multiple asymptomatic, skin colored to erythematous, symmetrical papules on face, trunk, and extremities, absence of systemic involvement and absence of mucosal lesions, history of spontaneous resolution of the lesions seen on the extremities, histopathological features of nodular aggregates of large histiocytes and absence of giant cells, and lastly the IHC studies showing histiocytes being CD 68 positive and S 100 negative, and electron microscopy showing absence of Birbeck granules.…”

Section: Discussionmentioning

confidence: 99%

Generalized eruptive histiocytosis mimicking leprosy

Kumar¹,

Nandini²,

Niveditha³

et al. 2011

Indian J Dermatol Venereol Leprol

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Generalized eruptive histiocytosis (GEH) is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage) of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

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Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia

Cited by 26 publications

References 31 publications

Generalised Annular Elastolytic Giant Cell Granuloma

Generalised Annular Elastolytic Giant Cell Granuloma

A Case of Generalized Eruptive Histiocytosis

Generalized eruptive histiocytosis mimicking leprosy

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