Generalized eczema due to codeine

Estrada, J. L.; Puebla, M J Alvarez; Urbina, Juan; Matilla, B.; Prieto, Manuel Ángel Rodríguez; Gozalo, F.

doi:10.1034/j.1600-0536.2001.440308-7.x

Cited by 15 publications

(2 citation statements)

References 3 publications

(4 reference statements)

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“…Many are histamine releasers; an effect that may sometimes lead to non-immune-mediated anaphylactic-like (anaphylactoid) 10 symptoms and this property is therefore reviewed here together with opioid-induced true anaphylactic (Type 1) immediate hypersensitivity reactions 11 mediated by specific immunoglobulin E (IgE) antibodies. Antibody-dependent Type 2 cytotoxic reactions, Type 3 reactions due to immune complexes, and Type 4 delayed-type cell-mediated responses 11 (collectively including maculopapular rash, erythema multiforme 12 , pustular rashes, pruritis, eczema 13,14 and so-called pseudoallergies 15 ) have not been covered since they fall outside the definition of true, Type 1 allergic responses.…”

Section: Anaphylactoid Reactions To Opioid Analgesicsmentioning

confidence: 99%

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Baldo¹,

Pham²

2012

Anaesth Intensive Care

138

105

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Opioid analgesics are amongst the most commonly administered drugs in hospitals. Whether natural or synthetic, they show some common structural features, morphine-like pharmacological action and binding specificity for complementary opioid receptors. Tramadol differs from the other opioid analgesics in possessing monoaminergic activity in addition to its affinity for the μ opioid receptor. Many opioids are potent histamine releasers producing a variety of haemodynamic changes and anaphylactoid reactions, but the relationship of the appearance of these effects to the histamine plasma concentration is complex and there is no direct and invariable relationship between the two. Studies of the histamine-releasing effects, chiefly centred on morphine, reveal variable findings and conclusions often due to a range of factors including differences in technical measurements, dose, mode of administration, site of injection, the anatomical distribution of histamine receptors and heterogeneity of patient responses. Morphine itself has multiple direct effects on the vasculature and other haemodynamically-active mediators released along with histamine contribute to the variable responses to opioid drug administration. Despite their heavy use and occasional apparent anaphylactic-like side-effects, immunoglobulin E antibodymediated immediate hypersensitivity reactions to the drugs are not often encountered. uncertainties associated with skin testing with these known histamine-releasers, and the general unavailability of opioid drug-specific immunoglobulin E antibody tests contribute to the frequent failure to adequately investigate and establish underlying mechanisms of reactions by distinguishing anaphylactoid from true anaphylactic reactions. Clinical implications for diagnosis of reactions and some speculations on the rarity of true Type 1 allergies to these drugs are presented.

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Section: Anaphylactoid Reactions To Opioid Analgesicsmentioning

confidence: 99%

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Baldo¹,

Pham²

2012

Anaesth Intensive Care

138

105

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show abstract

“…Allergic contact dermatitis (ACD) of the normal scalp is rare and at times may present in an atypical manner (1). The usual allergens in these cases include paraphenylenediamine (2), permanent wave solutions (3, 4), topical medicaments such as minoxidil (5, 6) and preservatives found in cosmetic shampoos (7) and leave‐on products. In many instances, patients will present with eczematous reactions along the scalp border extending to the preauricular areas, sparing the hair‐bearing scalp.…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis to nickel in a hair clasp

et al. 2007

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Glutardialdehyd [MAK Value Documentation in German language, 2002]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 35. Lieferung, Ausgabe 2002 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Einmalige Exposition Allergene Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Subakute, subchronische und chronische Toxizität Bewertung

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Generalized eczema due to codeine

Cited by 15 publications

References 3 publications

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Allergic contact dermatitis to nickel in a hair clasp

Glutardialdehyd [MAK Value Documentation in German language, 2002]

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