Generalized dermatitis due to codeine

Generalized eczema due to codeine

“…In our patient, the positive codeine patch test pointed to a Type IV allergic reaction. We also demonstrated cross‐reactivity with morphine but not with other opioid drugs such as tramadol or pentazocine; similar findings were obtained by Rodríguez et al (3). These observations might suggest that these latter drugs could be an alternative therapy when opioid drug treatment is essential…”

Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test

“…8,9 Only rarely have these been described after systemic use of opium alkaloids. [10][11][12] Given the relatively long interval between the start of morphine and the appearance of the eruption, previous sensitization seems unlikely. Besides, our patient experienced no earlier CADR and had not used or handled opium alkaloids before his presentation to us.…”

Acute generalised exanthematous pustulosis and other severe drug eruptions from over the counter medications: A case report and review of the literature

“…There are reports of DHS and erythroderma secondary to codeine. [6][7][8][9] When prescribing opiates for a patient with a pholcodine or codeine allergy there is a risk of cross reactivity and, where possible, an opiate from a different therapeutic class should be chosen. This would involve using fentanyl or methadone instead of morphine or oxycodone.…”