Generalized AA-Amyloidosis in Two Hares<i>(Lepus europaeus)</i>Immunohistochemically Identified Using Poly- and Monoclonal Antibodies

Geisel, O.; Linke, Reinhold P.

doi:10.1177/030098588802500511

Cited by 15 publications

(12 citation statements)

References 5 publications

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“…Ulcerative pododermatitis associated with multifocal visceral purulent lesions and generalized AAamyloidosis was observed only in reproducing hares and was caused by S. aureus, most likely predisposed by mechanical injury from the cage wire floor, as evidenced in rabbits (Rosell and de la Fuente, 2013). To our knowledge, ulcerative pododermatitis has never been documented in hares, but generalized AA-amyloidosis has been reported in free-living hares affected by chronic inflammation (Geisel and Linke, 1988).…”

Section: Discussionmentioning

confidence: 84%

Performance and mortality of farmed hares

Rigo

Trocino

Poppi

et al. 2015

Animal

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Performance and mortality of hares were evaluated for 2 consecutive years in a large farm in Veneto Region (Northern Italy). On average, fertile reproductive pairs (n = 318) gave birth 4.8 times and produced 11.4 live leverets, weaned 8.4 leverets and produced 7.0 growing hares (60 days) every year. Mean mortality was 3.6%, 22.9%, 9.7% and 2.5% in newborn (0 to 2 days of age), suckling (3 to 25 days), growing (26 to 60 days) and sub-adult (61 days until sale) hares, respectively. The main causes of mortality were enteric diseases (75.5%, 75.9% and 12.1% in suckling, growing and sub-adult hares, respectively), followed by respiratory diseases (3.4%, 8.0% and 36.2% in suckling, growing and sub-adult hares, respectively), starvation (11.3% and 8.8% in suckling and growing hares, respectively) and trauma (7.1%, 2.3% and 30.2% in suckling, growing and sub-adult hares, respectively). In reproducing hares, mortality was 24.7% and 15.4% in 2010 and 2011, respectively. Respiratory diseases (34.8%) and ulcerative pododermatitis (18.9%) were the most common pathological changes detected in reproducing hares. Farmed hares seem to be affected by diseases resembling those of rabbits reared under intensive conditions. It seems necessary to improve the husbandry of hares to reach satisfactory technical standards and to preserve their health.

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Section: Discussionmentioning

confidence: 84%

Performance and mortality of farmed hares

Rigo

Trocino

Poppi

et al. 2015

Animal

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“…In mammals, AA amyloidosis has been reported in canines [14,15], felines [16][17][18], bovines [19,20], ovines [21,22], porcines [23], equines [24], lagomorphs [25], and other species [6,26], besides other amyloid types [10].…”

Section: Introductionmentioning

confidence: 99%

Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab Emirates

Hampel

Kinne

Wernery

et al. 2009

Amyloid

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“…Amyloidosis is a systemic disease affecting humans and domestic animals with varying frequencies, and has also been reported in several wild animals, including zoo-kept Dorcas gazelles (Gazella dorcas) with Arcanobacterium pyogenes infections 43,58 , a zoo-bred and kept mountain gazelle (Gazella gazelle) 31 , zoo-bred and kept closely-related Siberian tigers (Pantheras tigris altaica) with no other disorders 45 , hares (Lepus europaeus) 22 , and captive cheetahs (Acinonyx jubatus), which had various chronic inflammatory diseases in other organs 12,36,38 . Amyloidosis is reportedly less common in cats than in dogs, with marked proteinuria being less prominent in cats due to predominantly medullary localisation of the amyloid, as opposed to glomerular deposition in dogs 35 .…”

Section: Introductionmentioning

confidence: 99%

“…Amyloid can be specifically stained with Congo Red, showing green birefringence under cross-polarised light, and it fluoresces strongly under ultraviolet light when stained with thioflavine-T 5,33 . Immunohistochemical staining using antibodies to amyloid A from various species with the indirect immunoperoxidase technique 22,31,32,45 is a specific test. Potassium permanganate oxidation of Congo red staining occurs with AA amyloid but not with AL amyloid 52 or pancreatic insular amyloid 55 .…”

Section: Introductionmentioning

confidence: 99%

Renal medullary AA amyloidosis, hepatocyte dissociation and multinucleated hepatocytes in a 14-year-old free-ranging lioness (Panthera leo)

Williams¹,

Wilpe²,

Momberg³

2005

J. S. Afr. Vet. Assoc.

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A 14-year-old lioness, originating from Etosha in Namibia, and a member of a pride in Pilanesberg National Park since translocation in 1994, was euthanased due to fight-related vertebral fracture and spinal injury, incurred approximately 6-8 weeks previously. Blood specimens collected at the time of death showed mild anaemia and a leukogram reflecting stress and chronic infection. Necropsy conducted within 2 hours of death was on a dehydrated, emaciated animal with hindquarter wasting and chronic traumatic friction injuries from dragging her hindlegs. There was cellulitis in the region of bite-wounds adjacent to the thoraco-lumbar vertebral fracture, at which site there was spinal cord compression, and there was marked intestinal helminthiasis. The outer renal medullae appeared pale and waxy and the liver was macroscopically unremarkable. Histopathology and electron microscopy of the kidneys revealed multifocal to coalescing deposits of proximal medullary interstitial amyloid, which fluoresced strongly with thioflavine T, and was sensitive to potassium permanganate treatment prior to Congo Red staining, thus indicating inflammatory (AA) origin. There was diffuse hepatocyte dissociation, as well as numerous binucleated and scattered multinucleated (up to 8 nuclei/cell) hepatocytes, with swollen hepatocyte mitochondria, in liver examined light microscopically. Ultrastructurally, the mono-, bi- and multinucleated hepatocytes contained multifocal irregular membrane-bound accumulations of finely-granular, amorphous material both intra-cytoplasmically and intra-nuclearly, as well as evidence of irreversible mitochondrial injury. The incidence and relevance in cats and other species of amyloidosis, particularly with renal medullary distribution, as well as of hepatocyte dissociation and multinucleation, as reported in selected literature, is briefly overviewed and their occurrence in this lioness is discussed.

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Generalized AA-Amyloidosis in Two Hares(Lepus europaeus)Immunohistochemically Identified Using Poly- and Monoclonal Antibodies

Abstract: Brief Communications 39 1 and electron microscopic studies, as in man, failed to incriminate a common cause.

Cited by 15 publications

References 5 publications

Performance and mortality of farmed hares

Performance and mortality of farmed hares

Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab Emirates

Renal medullary AA amyloidosis, hepatocyte dissociation and multinucleated hepatocytes in a 14-year-old free-ranging lioness (Panthera leo)

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