Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab Emirates

Hampel, Mirjam Ricarda; Kinne, Jöerg; Wernery, Ulrich; Pospischil, Andreas; Kellermann, Josef; Linke, Reinhold P.

doi:10.1080/13506120903090759

Cited by 15 publications

(9 citation statements)

References 59 publications

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“…Edman degradation revealed a free N-terminus. The amino acid sequence of Herring gull protein AA from this study is shown in Fig 5 together with those from several avian and mammalian species [ 12 , 14 , 23 , 24 , 25 , 26 , 27 ]. As seen, the sequence was highly conserved but varied significantly at the N-terminus to the completely conserved F6 (numbering according to the human AA sequence).…”

Section: Resultsmentioning

confidence: 99%

“…Unexpectedly, amorphous eosinophilic materials consistent with amyloid deposits were observed microscopically in one-third of affected and unaffected Herring gulls investigated during an outbreak of botulism [ 4 ]. Systemic amyloidosis has long been recognized in captive animals, including birds [ 8 , 9 , 10 , 11 , 12 ]. Marine and coastal birds in captivity, especially those of the orders Anseriformes , Gruiformes and Charadriiformes (to which genus Larus belongs) seem to be particularly prone to develop amyloidosis.…”

Section: Introductionmentioning

confidence: 99%

“…Like in mammalian AA amyloidosis, the avian form is systemic with deposits in many different organs except brain [ 12 ]. The clinical signs in humans are usually renal with proteinuria due to glomerular deposits, although other consequences may also develop.…”

Section: Introductionmentioning

confidence: 99%

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Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)

et al. 2018

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Since the late 1990s, high mortality and declining populations have been reported among sea birds including Herring gulls (Larus argentatus) from the Baltic Sea area in Northern Europe. Repeated BoNT type C/D botulism outbreaks have occurred, but it remains unclear whether this is the sole and primary cause of mortality. Thiamine deficiency has also been suggested as a causal or contributing factor. With this study, we aimed to investigate gross and microscopic pathology in Herring gulls from affected breeding sites in Sweden in search of contributing diseases. Herring gulls from Iceland served as controls. Necropsies and histopathology were performed on 75 birds, of which 12 showed signs of disease at the time of necropsy. Parasites of various classes and tissues were commonly observed independent of host age, e.g. oesophageal capillariosis and nematode infection in the proventriculus and gizzard with severe inflammation, air sac larid pentastomes and bursal trematodiasis in pre-fledglings. Gross and microscopic findings are described. Notably, amyloidosis was diagnosed in 93 and 33% of the adult birds from Sweden and Iceland, respectively (p<0.001), with more pronounced deposits in Swedish birds (p<0.001). Gastrointestinal deposits were observed in the walls of arteries or arterioles, and occasionally in villi near the mucosal surface. Amyloid was identified within the intestinal lumen in one severely affected gull suggesting the possibility of oral seeding and the existence of a primed state as previously described in some mammals and chickens. This could speculatively explain the high occurrence and previously reported rapid onset of amyloidosis upon inflammation or captivity in Herring gulls. Amyloid-induced malabsorbtion is also a possibility. The Herring gull SAA/AA protein sequence was shown to be highly conserved but differed at the N-terminus from other avian species.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)

et al. 2018

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“…2) as in Ruder et al 26 The occurrence of splenic amyloidosis is not surprising, as reactive systemic amyloidosis is not rare in birds and often occurs as a consequence of chronic inflammation and increased serum amyloid A protein. 7 …”

Section: Discussionmentioning

confidence: 99%

Mycoplasma Corogypsi–Associated Polyarthritis and Tenosynovitis in Black Vultures (Coragyps atratus)

et al. 2012

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Three wild American black vultures (Coragyps atratus) were presented to rehabilitation centers with swelling of multiple joints, including elbows, stifles, hocks, and carpal joints, and of the gastrocnemius tendons. Cytological examination of the joint fluid exudate indicated heterophilic arthritis. Radiographic examination in 2 vultures demonstrated periarticular soft tissue swelling in both birds and irregular articular surfaces with subchondral bone erosion in both elbows in 1 bird. Prolonged antibiotic therapy administered in 2 birds did not improve the clinical signs. Necropsy and histological examination demonstrated a chronic lymphoplasmacytic arthritis involving multiple joints and gastrocnemius tenosynovitis. Articular lesions varied in severity and ranged from moderate synovitis and cartilage erosion and fibrillation to severe synovitis, diffuse cartilage ulceration, subchondral bone loss and/or sclerosis, pannus, synovial cysts, and epiphyseal osteomyelitis. No walled bacteria were observed or isolated from the joints. However, mycoplasmas polymerase chain reactions were positive in at least 1 affected joint from each bird. Mycoplasmas were isolated from joints of 1 vulture that did not receive antibiotic therapy. Sequencing of 16S rRNA gene amplicons from joint samples and the mycoplasma isolate identified Mycoplasma corogypsi in 2 vultures and was suggestive in the third vulture. Mycoplasma corogypsi identification was confirmed by sequencing the 16S-23S intergenic spacer region of mycoplasma isolates. This report provides further evidence that M. corogypsi is a likely cause of arthritis and tenosynovitis in American black vultures. Cases of arthritis and tenosynovitis in New World vultures should be investigated for presence of Mycoplasma spp, especially M. corogypsi.

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“…AA amyloidosis has been and still is a problem in the maintaining of several species of mammals and birds in captivity. It provides an economic loss in goose and duck farms , is associated with risk of extinction of certain species such as cheetah and causes loss of birds in falconry . The disease may also be important in the death of wild animals such as herring gulls in Sweden (Jansson et al ., unpublished data), European hares in Austria (A. Posautz, personal communication) and island foxes in California .…”

Section: Systemic Amyloidosismentioning

confidence: 99%

Transmissible amyloid

et al. 2016

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There are around 30 human diseases associated with protein misfolding and amyloid formation, each one caused by a certain protein or peptide. Many of these diseases are lethal and together they pose an enormous burden to society. The prion protein has attracted particular interest as being shown to be the pathogenic agent in transmissible diseases such as kuru, Creutzfeldt–Jakob disease and bovine spongiform encephalopathy. Whether similar transmission could occur also in other amyloidoses such as Alzheimer's disease, Parkinson's disease and serum amyloid A amyloidosis is a matter of intense research and debate. Furthermore, it has been suggested that novel biomaterials such as artificial spider silk are potentially amyloidogenic. Here, we provide a brief introduction to amyloid, prions and other proteins involved in amyloid disease and review recent evidence for their potential transmission. We discuss the similarities and differences between amyloid and silk, as well as the potential hazards associated with protein‐based biomaterials.

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Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab Emirates

Abstract: Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab EmiratesHampel, M R Hampel, M R. Increasing fatal AA amyloidosis in hunting falcons and how to identify the risk: a report from the United Arab Emirates.

Cited by 15 publications

References 59 publications

Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)

Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)

Mycoplasma Corogypsi–Associated Polyarthritis and Tenosynovitis in Black Vultures (Coragyps atratus)

Transmissible amyloid

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