Generalization of the Thermal Dose of Hyperthermia in Oncology

Vincze, Gyula; Szász, Olivér; Szász, András

doi:10.4236/ojbiphy.2015.54009

Cited by 25 publications

(25 citation statements)

References 79 publications

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“…The most plausible solution for this is measuring the temperature in the target, which could give approximate information about the absorbed heat. Unfortunately, measuring the temperature has numerous technical and physiological complications, which are discussed elsewhere [11], [12].…”

Section: Discussionmentioning

confidence: 99%

Considering skin physiology in capacitive-coupled hyperthermia

Szász

2016

JAP

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Dominant technical solution for oncological hyperthermia devices is capacitive-coupling. However, it has the challenge of overheating the surface of adipose layers and burning cutaneous structures. The main technical solution of this is the intensive cooling of the surface. Our objective is studying the physiology and effect of the active cooling of the skin in capacitive-coupled hyperthermia technologies.

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Section: Discussionmentioning

confidence: 99%

Considering skin physiology in capacitive-coupled hyperthermia

Szász

2016

JAP

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“…The difference between the two matching methods in capacitive coupling techniques well observable and proven [44]. The apoptotic signal can be induced with much smaller energy (and field) than the necrotic [45], which is shown in the strict synergy of the heat and field effects [46].…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia Dosing and Depth of Effect

Szász¹,

Peter²,

Vancsik³

et al. 2018

OJBIPHY

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The penetration depth in the electromagnetic heating could be a crucial factor of its application, when the deep heating is the goal. The capacitive coupling is one of the most popular heating techniques in radiofrequency (RF) heating applications. The matching of the target defines the penetration possibilities. The current matched solution has deeper mathematically defined penetration in RF region than the capacitive plane-wave solution. The same power of application request high voltage with relatively low current for plane-wave inducing, while in current matching it has low voltage with high current. The effective depth of the action in the two solutions do not identical, the penetration defined by the intensity of 1/e portion of the incident beam is higher in the current-matched techniques.

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“…The electric excitation could also have a role which is shown in the generalization of the CEM concept [81].…”

Section: Discussionmentioning

confidence: 99%

Electrokinetics of Temperature for Development and Treatment of Effusions

Szász¹,

Szigeti²,

Szász³

2017

ABB

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Introduction: Hyperthermia is a complementary therapy in oncology having various pros and contras for its application. Ascites, pleural effusion, edema and other electrolyte accumulations are frequently excluded from the treatability of the patients with heating locally or systemically. The special gathering of electrolytes is sometimes contraindicated, at times not mentioned in the clinical protocols. However, it is certainly challenging in the oncology where micro and macro edemas, as well as larger electrolyte accumulations (e.g. ascites, pleural effusion), are very frequent. Methods: Excluding patients with accumulation of free electrolytes limits the applications of hyperthermia. To find a solution we are studying the microvasculature and fluid dynamism together with the electric field effects, including the injury currents. The hyperthermia method which we investigate is the modulated electro-hyperthermia (mEHT). We use the Starling's equation and the injury current in the frame of non-equilibrium thermodynamics and in connection with the biologically closed electric circuits. Results: It is shown that mEHT, unlike the conventional hyperthermia, is applicable for patients who have edema and other free-electrolytes in the volume which is targeted. The heterogeneous heating (unlike the homogeneous, isothermal conventional hyperthermia) promotes the development of tumor-specific immune actions, and so has less adverse-effects, and longer survival time for patients in advanced, metastatic cancers too. Conclusion: mEHT is well applicable in cases of ascites, pleural effusion, edema and other electrolyte accumulations when a patient is treated in complex (complementary) oncological therapy.

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Generalization of the Thermal Dose of Hyperthermia in Oncology

Cited by 25 publications

References 79 publications

Considering skin physiology in capacitive-coupled hyperthermia

Considering skin physiology in capacitive-coupled hyperthermia

Hyperthermia Dosing and Depth of Effect

Electrokinetics of Temperature for Development and Treatment of Effusions

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