Considering skin physiology in capacitive-coupled hyperthermia

Szász, Olivér; Szász, András

doi:10.24297/jap.v11i8.206

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Due to the lost portion of the energy being unknown, the overall energy supplied cannot be used as a treatment dose parameter, the energy balance of the penetration loses its trustworthiness. • The physiological regulation of blood flow makes the situation complicated (163). The cooled surface will experience vasocontraction, and this layer will become more insulative, as a normal physiological reaction, limiting heat loss.…”

Section: Efforts To Reduce the Energy-lossmentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable localregional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively simple physical-physiological concepts behind hyperthermia, its development was not steady, and it has gone through periods of failures and renewals with mixed views on the benefits of heating seen in the medical community over the decades. In this review we study in detail the various techniques currently available and describe challenges and trends of oncological hyperthermia from a new perspective. Our aim is to describe what we believe to be a new and effective approach to oncologic hyperthermia, and a change in the paradigm of dosing. Physiological limits restrict the application of WBH which has moved toward the mild temperature range, targeting immune support. LRHT does not have a temperature limit in the tumor (which can be burned out in extreme conditions) but a trend has started toward milder temperatures with immune-oriented goals, developing toward immune modulation, and especially toward tumor-specific immune reactions by which LRHT seeks to target the malignancy systemically. The emerging research of bystander and abscopal effects, in both laboratory investigations and clinical applications, has been intensified. Our present review summarizes the methods and results, and discusses the trends of hyperthermia in oncology.

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Section: Efforts To Reduce the Energy-lossmentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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“…, the transporting electrolytes (mainly the blood perfusion) change of the electric parameters by time and temperature. These processes are dominantly physiologically regulated, so homeostatic control has substantial importance in the changing electromagnetic properties [81]. The higher dielectric permittivity of the tumor cells and mass gives an additional selection factor [82] to the higher conductivity discussed above.…”

Section: Introductionmentioning

confidence: 99%

Memristor Hypothesis in Malignant Charge Distribution

Szasz

2023

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Tissues in biological objects from the point of view of electromagnetic effects must be modeled not only for their conductivity. The ionic double layer induced by the electric field, built by electrolytic diffusion, must be counted. The micro (frequency dispersion phenomena) and macro (interfacial polarization), as well as more generalized by Nernst-Planck cells describe the biophysical aspects of this phenomena. The charge distribution depends on the processes and produces charge gradients in space. The dynamic feasibility of the-charge transition layer has memory and adaptability, working like a memristor in cancerous development. The memristor processes may complete the adaptation mechanisms of cancer cells to extremely stressful conditions. Our objective is to show the distribution and redistribution of space charges that generate memristors and internal currents like injury current (IC) in the development of cancer. We show some connected aspects of the modulated electrohyperthermia (mEHT) limiting the proliferation process in the micro-range like the macro-range electrochemotherapy (ECT) processes do. The internal polarization effects form space-charge, which characteristically differ in malignant and healthy environments. The electrical resistivity of the electrolytes depends on the distribution of the charges and concentrations of ions in the electrolytes, consequently the space-charge differences appear in the conductivity parameters too. The polarization heterogeneities caused by the irregularities of the healthy tissue induce a current (called injury current), which appears in the cancerous tumor as well. Due to the nonlinearity of the space-charge production and the differences of the relaxation time of the processes in various subunits. The tumor develops the space-charge which appears as an inductive component in the otherwise capacitive setting and forms a memristive behavior of the tumorous tissue. This continuously developing space-charge accommodates the tumor to the permanently changing conditions and helps the adopting the malignant cells in the new environment.

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Considering skin physiology in capacitive-coupled hyperthermia

Cited by 2 publications

References 10 publications

Quo Vadis Oncological Hyperthermia (2020)?

Quo Vadis Oncological Hyperthermia (2020)?

Memristor Hypothesis in Malignant Charge Distribution

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