Generalised wavelet analysis of cutaneous flowmotion during post-occlusive reactive hyperaemia in patients with peripheral arterial obstructive disease

Rossi, Mônica Lanzoni; Bertuglia, Silvia; Varanini, M.; Giusti, Andrea; Santoro, Gino; Carpi, Angelo

doi:10.1016/j.biopha.2004.01.008

Cited by 54 publications

(57 citation statements)

References 22 publications

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“…Notably, vasomotion can be further assessed by spectral analysis of baseline skin perfusion [35]. In former studies spectral analysis revealed impaired neurogenic activity in patients with diabetes mellitus [36].…”

Section: Discussionmentioning

confidence: 99%

Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus

et al. 2012

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Aims/hypothesis Deterioration of microvascular function may have an early onset in individuals with type 1 diabetes mellitus. We hypothesised that microvascular autoregulation is impaired in children with type 1 diabetes and can be detected non-invasively by postocclusive reactive hyperaemia (PORH). Methods Microvascular autoregulation was assessed in 58 children with type 1 diabetes and 58 age-and sex-matched healthy controls by PORH using laser Doppler fluxmetry. Baseline perfusion, biological zero (defined as a 'no flow' laser Doppler signal during suprasystolic occlusion), peak perfusion following occlusion, time to peak and recovery time (time until baseline perfusion is resumed) were recorded and compared between the groups.Results Peak perfusion was higher in children with type 1 diabetes than in healthy controls (1.7±0.93 AU [arbitrary units] vs 1.29±0.46 AU; p00.004), and biological zero was lower in children with type 1 diabetes vs controls (0.14± 0.04 AU vs 0.19±0.04 AU; p<0.0001). No differences were seen between the groups in baseline perfusion, time to peak during PORH and recovery time following PORH. Conclusions/interpretation PORH reveals impaired microvascular autoregulation in children with type 1 diabetes. The higher peak perfusion might reflect a decline in the vasoconstrictive ability of arteriolar smooth muscle cells upstream of capillary beds in children with type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus

et al. 2012

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“…Another study proposes compensatory mechanisms as a reason for the amplification in this frequency interval. 27 Further on an altered nitric oxide level that has been reported in patients with schizophrenia 3 might cause the different dynamic behavior between both groups. More recently an additional endothelium related frequency interval from 0.005 to 0.01 Hz was disclosed 21,32 providing information about the endothelium-derived hyperpolarizing factors related endothelial activity.…”

Section: Segmented Spectral Analysis Of Hyperemiamentioning

confidence: 99%

“…This has already been proven by Ostergren et al who showed that a denervation is associated with a disappearance of components in this subinterval. 25,27 An increased sympathetic activity in patients with schizophrenia has been reported based on the measure of a QT variability index 6 as well as on the interaction between autonomic regulation and the pupil diameter. 5 The fact that this increase in sympathetic activity is not detectable in the total spectral analysis of the hyperemic stage might be caused by the strong variations that can be seen in the segmented analysis in the control group.…”

Section: Segmented Spectral Analysis Of Hyperemiamentioning

confidence: 99%

“…24 Skin blood flow parameters derived from a LDF signal were significantly altered in patients with stage II of peripheral arterial obstructive disease (PAOD) and critical limb ischemia in the diseased leg. 27, 28 Rossi et al 29 also found a modified microcirculatory pattern in patients with essential arterial hypertension (EHT) depending on the duration of this hypertensive pathological condition. The myogenic and sympathetic components of the blood flow signal were impaired in recently diagnosed patients; where as in patients with long standing and treated EHT endothelial and sympathetic components were affected.…”

Section: Introductionmentioning

confidence: 95%

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Dynamic Microvascular Blood Flow Analysis During Post-Occlusive Reactive Hyperemia Test in Patients with Schizophrenia

et al. 2011

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Patients suffering from schizophrenia have an increased mortality risk due to cardiovascular events. Recently the analysis of peripheral circulation has revealed interesting results in the study of vascular pathological conditions assuming that the state of microcirculation of the skin is at least partly representative for the constitution of other vascular beds including those of the cardiac muscle and arteries. The objective of this study was to investigate the microcirculation in patients with acute schizophrenia (PAT, n = 15, mean age 33.0 years, 7 male, 8 female) to identify whether spectral features from blood flow signals derived through laser Doppler spectrometry are significantly altered compared to healthy subjects (CON, n = 15, mean age 32.4 years, 7 male, 8 female) by means of the post-occlusive reactive hyperemia test. It was also explored if a segmentation of the post-ischemic stage can disclose more detailed and additional information about the dynamic behavior of the blood flow during hyperemic response. For this reason, time-frequency analyses were performed to observe the course of the blood flow frequency components over time. Our results indicate significant differences in the patients group, already detectable under baseline conditions but also in the hyperemic phase. The main modifications affect the respiratory (p = 0.006) as well as the cardiac (p = 0.001) activity. It was further shown that the application of a segmented analysis of the post-ischemic state considerably improves the differentiation between both groups. Only with the introduced segmentation algorithm using a window length of 2048 samples and a shift of 128 and 256 samples we could demonstrate influences of the disease on the endothelial (p = 0.029), the sympathetic (p = 0.019) and the myogenic (p = 0.029) mechanisms. These information provide further insights into the appearance of schizophrenia and could lead to an improvement of the patients' treatment to avoid the occurrence of cardiovascular events.

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“…The power density spectral distribution was obtained by time averaging the time-frequency power density representation. This technique permits evaluation of nonstationary data, such as those represented by rhythmic variations in vessel diameters [34]. …”

Section: Methodsmentioning

confidence: 99%

Low-Frequency Components in Rat Pial Arteriolar Rhythmic Diameter Changes

et al. 2017

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This study aimed to analyze the frequency components present in spontaneous rhythmic diameter changes in rat pial arterioles. Pial microcirculation was visualized by fluorescence microscopy. Rhythmic luminal variations were evaluated via computer-assisted methods. Spectral analysis was carried out on 30-min recordings under baseline conditions and after administration of acetylcholine (Ach), papaverine (Pap), Nω-nitro-L-arginine (L-NNA) prior to Ach, indomethacin (INDO), INDO prior to Ach, charybdotoxin and apamin, and charybdotoxin and apamin prior to Ach. Under baseline conditions all arteriolar orders showed 3 frequency components in the ranges of 0.0095-0.02, 0.02-0.06, and 0.06-0.2 Hz, another 2 in the ranges of 0.2-2.0 and 2.5-4.5 Hz, and another ultra-low-frequency component in the range of 0.001-0.0095 Hz. Ach caused a significant increase in the spectral density of the frequency components in the range of 0.001-0.2 Hz. Pap was able to slightly increase spectral density in the ranges of 0.001-0.0095 and 0.0095-0.02 Hz. L-NNA mainly attenuated arteriolar responses to Ach. INDO prior to Ach did not affect the endothelial response to Ach. Charybdotoxin and apamin, suggested as endothelium-derived hyperpolarizing factor inhibitors, reduced spectral density in the range of 0.001-0.0095 Hz before and after Ach administration. In conclusion, regulation of the blood flow distribution is due to several mechanisms, one of which is affected by charibdotoxin and apamin, modulating the vascular tone.

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Generalised wavelet analysis of cutaneous flowmotion during post-occlusive reactive hyperaemia in patients with peripheral arterial obstructive disease

Cited by 54 publications

References 22 publications

Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus

Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus

Dynamic Microvascular Blood Flow Analysis During Post-Occlusive Reactive Hyperemia Test in Patients with Schizophrenia

Low-Frequency Components in Rat Pial Arteriolar Rhythmic Diameter Changes

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