General solution for diffusion‐controlled dissolution of spherical particles. 2. Evaluation of experimental data

Wang, Jianzhuo; Flanagan, Douglas R.

doi:10.1002/jps.10039

Cited by 77 publications

(72 citation statements)

References 18 publications

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“…So the question arises as to how does a smaller particle size affect this parameter? It has been experimentally proved in a number of studies that the smaller the particle size, the smaller the diffusion layer thickness and the higher the dissolution rate (Bisrat and Nystrom 1988;Hintz and Johnson 1989;Wang and Flanagan 2002;Tinke et al 2005). The relationship between the boundary layer thickness and the particle size can be best understood using the Prandtl equation:…”

Section: Increased Saturation Solubility and Dissolution Ratementioning

confidence: 98%

Solid Nanosuspensions: The Emerging Technology and Pharmaceutical Applications as Nanomedicine

Verma

Burgess

2009

Pharmaceutical Suspensions

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One of the foremost reasons for such a widespread interest in nanosuspensions as drug delivery systems is their ability to provide formulations of poorly soluble drugs with increased saturation solubility and higher dissolution rates. Nanosuspensions manifest these properties because of their small size and high surface area. The unique properties of the nanosuspensions along with their fast development times, low production costs, ease of manufacture and scale-up as well as their ability to extend the lifecycle of off-patent drugs have resulted in rapid commercialization. Nanosuspensions provide us with a useful tool for formulating an ever-increasing number of poorly water soluble drugs in pharmaceutical development programs.

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Section: Increased Saturation Solubility and Dissolution Ratementioning

confidence: 98%

Solid Nanosuspensions: The Emerging Technology and Pharmaceutical Applications as Nanomedicine

Verma

Burgess

2009

Pharmaceutical Suspensions

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“…The diameter of the particle is denoted d p . Square symbols represent the data from Wang and Flanagan [40]. The unfilled circles represent data from Mosharraf and Nystrçm [41].…”

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confidence: 99%

“…The square symbols in Fig. 4 are based on the Wang -Flanagan study [40] of benzocaine. Nonporous crystalline spherical particles, selected from a range of sizes (100 -1000 mm), were characterized in a single-particle flow dissolution system (2.8 cm min À 1 , equivalent to ca.…”

mentioning

confidence: 99%

“…A polydisperse lognormal population of particles may be divided into N groups according to particle size. Each ith group of particles with nearly the same size can then be treated as a monodisperse population, with a Nernst -Brünner-like equation describing the dissolution kinetics [40] vs. normalized concentration (C(x)/S) profile across the ABL at steady state under sink conditions, where S is the solubility. The dash-dot-dot curve represents small particles, whose radius, a, is ten times less than the expected thickness of the ABL for a rotating disk system, h [49].…”

mentioning

confidence: 99%

“…Five model compounds were studied with the novel powder-based method, using as little as 0.05 mg of API in 1 ml of pH 1.2, 4.5, and 6.8 buffer media. Two computational approaches were used to analyze powder dissolution curves: a) a biexponential spherical particle equation (assuming particle size remains practically unchanged during dissolution), and b) the Wang -Flanagan non-sink spherical particle equation [39] [40] (not assuming constancy of particle size). The objectives of the study was to demonstrate that powder dissolution data can be useful for estimating particle size, so that particle preparative methods (milling, wettability treatment, etc.)…”

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confidence: 99%

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Avdeef

Tsinman

et al. 2009

Chemistry & Biodiversity

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The objective was to investigate the applicability and limitations of an approach for estimating particle size from powder dissolution measurement using as little as 50 microg of sample in 1 ml of buffer solutions. The powder dissolution profiles of five sparingly-soluble drugs (hydrochlorothiazide, phenazopyridine hydrochloride, 2-naphthoic acid, indomethacin, and dipyridamole) were evaluated with a novel biexponential spherical particle equation and also the Wang-Flanagan spherical particle non-sink equation. The results were compared to particle sizing based on measured specific surface area by the Brunauer-Emmett-Teller (BET) method, and also based on Coulter counting. With the exception of hydrochlorothiazide, the model compounds indicated some agglomeration in the dissolution media. The dry-state specific surface area was larger than expected from either the Coulter method or the powder-dissolution data, especially for phenazopyridine hydrochloride. The particle radii estimated by the powder dissolution method ranged from 10 to 68 microm, with equilibrium solubilities spanning from 5 microg/ml (dipyridamole) to 911 microg/ml (hydrochlorothiazide). Powder dissolution data collected with the miniaturized apparatus can be used to determine particle size, with estimated values agreeing reasonably with those measured by the Coulter counter method.

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Physiological Model for Absorption

Peters

2012

Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations

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General solution for diffusion‐controlled dissolution of spherical particles. 2. Evaluation of experimental data

Cited by 77 publications

References 18 publications

Solid Nanosuspensions: The Emerging Technology and Pharmaceutical Applications as Nanomedicine

Solid Nanosuspensions: The Emerging Technology and Pharmaceutical Applications as Nanomedicine

Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Physiological Model for Absorption

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