Novel Corona Virus Disease originating from China has rapidly crossed borders, infecting people throughout the whole world. This phenomenon has led to a massive public reaction; the media has been reporting continuously across borders to keep all informed about the pandemic situation. All these things are creating a lot of concern for people leading to heightened levels of anxiety. Pandemics can lead to heightened levels of stress; Anxiety is a common response to any stressful situation. This study attempted to assess the knowledge, attitude, anxiety experience, and perceived mental healthcare need among adult Indian population during the COVID-19 pandemic. An online survey was conducted using a semi-structured questionnaire using a non-probability snowball sampling technique. A total of 662 responses were received.The responders had a moderate level of knowledge about the COVID-19 infection and adequate knowledge about its preventive aspects. The attitude towards COVID-19 showed peoples' willingness to follow government guidelines on quarantine and social distancing. The anxiety levels identified in the study were high. More than 80 % of the people were preoccupied with the thoughts of COVID-19 and 72 % reported the need to use gloves, and sanitizers. In this study, sleep difficulties, paranoia about acquiring COVID-19 infection and distress related social media were reported in 12.5 %, 37.8 %, and 36.4 % participants respectively. The perceived mental healthcare need was seen in more than 80 % of participants. There is a need to intensify the awareness and address the mental health issues of people during this COVID-19 pandemic.

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An atomic force microscopy (AFM) method was successfully developed and utilized for investigating the interaction of polymeric stabilizers with ibuprofen to determine their suitability for the preparation and stabilization of ibuprofen nanosuspensions. Images obtained clearly showed that HPMC and HPC interacted strongly with the ibuprofen resulting in extensive surface adsorption, confirming their suitability for ibuprofen nanosuspension preparation. In addition, differences in the morphology of the adsorbed HPMC and HPC molecules were observed, which may be attributed to their variable degree of substitution. Consistent with their poor performance in stabilizing the ibuprofen nanosuspensions, images obtained with PVP and Poloxamer's depicted inadequate adsorption on the ibuprofen surface. Careful analysis of the AFM images and the ibuprofen crystal structure gave valuable insight into the success of top-down processing for the preparation of nanosuspensions as compared to bottom-up processing. On the basis of the relationship observed between nanosuspension stability and adsorption characteristics of specific polymers, such AFM studies can aid in the selection of suitable nanosuspension stabilizers. This method provides the basis for a scientific rationale for nanosuspension stabilizer selection rather than the trial and error method which is currently practiced.