General Principles of Suspensions

Nutan, Mohammad T. H.; Reddy, Indra K.

doi:10.1007/978-1-4419-1087-5_2

Cited by 38 publications

(50 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This physical unstability may be due to the high energy at high temperature which may cause the agglomeration of the vesicles. The zetapotential values of the elastic anionic niosomes loaded and not loaded with insulin or the insulin-Tat mixture were in the unstable range (not within ±30 mV) (Nutan & Reddy, 2009). Also, a significant decrease (p50.05) in zeta-potential of the elastic anionic niosomes loaded with insulin at 40 ± 2 C and elastic anionic niosomes loaded with insulin-Tat mixture at all storage temperatures were observed.…”

Section: Niosomal Formulations Human Insulin Tatmentioning

confidence: 92%

Hypoglycemic activity and stability enhancement of human insulin–tat mixture loaded in elastic anionic niosomes

et al. 2016

View full text Add to dashboard Cite

This study aimed to investigate the synergistic effect of trans-activator of transcription (Tat) and niosomes for the improvement of hypoglycemic activity of orally delivered human insulin. The elastic anionic niosomes composing of Tween 61/cholesterol/dicetyl phosphate/sodium cholate at 1:1:0.05:0.02 molar ratio loaded with insulin-Tat mixture (1:3 molar ratio) was prepared. Deformability of the elastic anionic niosomes decreased after loaded with the mixture of 1.35 times. For the in vitro release, the insulin (T 10 ¼ 4 h) loaded in the elastic anionic niosomes indicated the slower release rate than insulin in the mixture (T 10 ¼ 3 h) loaded in niosomes. At room temperature (30 ± 2 C), the mixture loaded in elastic anionic niosomes was more chemical stable than the free mixture of 1.3, 1.4 and 1.7 times after stored for 4, 8 and 12 weeks, respectively. Oral administration in the alloxan-induced diabetic mice of the mixture loaded in elastic anionic niosomes with the insulin doses at 25, 50 and 100 IU/kg body weight indicated significant hypoglycemic activity with the percentage fasting blood glucose reduction of 1.95, 2.10 and 2.10 folds of the subcutaneous insulin injection at 12 h, respectively. This study has demonstrated the synergistic benefits of Tat and elastic anionic niosomes for improving the hypoglycemic activity of the orally delivered human insulin as well as the stability enhancement of human insulin when stored at high temperature. The results from this study can be further developed as an effective oral insulin delivery.

show abstract

Section: Niosomal Formulations Human Insulin Tatmentioning

confidence: 92%

Hypoglycemic activity and stability enhancement of human insulin–tat mixture loaded in elastic anionic niosomes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Sedimentation rate (Rs) may be expressed, at low particle concentration, in discrete settling mode as Equation 1 according to Stokes (Nutan and Reddy, 2010). …”

Section: Methodsmentioning

confidence: 99%

“…The visual observation employed did not give much clue on interactions except that at temperatures above 40 o C, it was observed that the haziness of the suspension mixtures (particularly the 0.02M concentration), as seen through the transparent settleometer, slightly decreased. Although, rising temperature also causes decrease in medium viscosity (Nutan and Reddy, 2010), it is likely that the degree of interactions (particle-particle and particle-medium) out-weighed the decrease of viscosity and sedimentation rate of precipitate, Rs, may be expressed as (Victor et al, 2007) (Tables 1 and 2) indicate that, at constant phosphate ions concentration, sedimentation order with respect to metal ions (a) ranged between 0.63 and 1.23 for TCP and 0.58 and 1.31 for TSP. Also, at constant metal ions concentration, sedimentation order with respect to phosphate ions concentration (b) ranged between 1.52 and 2.10 for TCP and 1.55 and 1.81 for TSP.…”

Section: Methodsmentioning

confidence: 99%

“…Mathematical models such as those by Stokes and Vesilind respectively describe sedimentation of particles in dilute and concentrated suspension media (Nutan and Reddy, 2010;Zhang et al, 2015). According to Kazadi-Mbamba et al, (2015) existing models have limited description for physico-chemical processes such as precipitation, possibly due to design limitations.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Influence of temperature and ion concentration on sedimentation characteristics of Tricalcium phosphate (TCP) and Tristrontium phosphate (TSP) Precipitates

Obunwo¹,

Iboroma²,

Cookey³

2018

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

Physical and chemical variables of insoluble salts generally affect sedimentation characteristics of precipitates. In this research study, the effects of temperature and ion concentration on the sedimentation of tricalcium phosphate (TCP) and tristrontium phosphate (TSP) were studied. The focus was to determine the sedimentation kinetics such as rate, order and rate constant of TCP and TSP at varying temperatures using the modified initial rate (Isolation) method. It was observed that whereas effect of temperature was not significant, low concentrations (< 0.04M) of the metal and phosphate ions markedly influenced the initial sedimentation rates of TCP and TSP precipitates.TCP sedimentation order ranged between 0.63 and 1.23 at constant phosphate ions concentration and between 1.52 and 2.10 at constant calcium ions concentration. TSP sedimentation order also ranged between 0.58 and 1.31 at constant phosphate ions concentration and between 1.55 and 1.81 at constant strontium ions concentration. Furthermore, ranges of sedimentation rate constants were obtained. At constant phosphate ions concentration, 1.80 × 10 -4 -1.57 × 10 -3 and 1.51 × 10 -4 -2.45 × 10 -3 were obtained for TCP and TSP, respectively. At constant metal ions concentration 1.71 × 10 -5 -9.54 × 10 -5 and 5.70 × 10 -5 -1.12 × 10 -4 were respectively obtained for TCP and TSP. Data may be employed as additional design information for modeling physiochemical phosphate removal in water treatment technology.

show abstract

“…35 In another study gallic acid which gave excellent docking scores on HIV reverse transcriptase and found to have inhibitory activity on the same. 36 Dengue and chikungunya are viruses of contemporary time and based on the above studies, docking protocol can help for rationale selection of natural compounds and plants against these viruses.…”

mentioning

confidence: 99%