General aspects of trace elements and health

Peereboom, J. W. Copius

doi:10.1016/0048-9697(85)90003-8

Cited by 39 publications

(23 citation statements)

References 48 publications

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“…The role of different trace metals in the normal vital activities and initiation of some diseased has long been known [10,11]. Nevertheless, until recently clinical recognition was limited to very few of the trace metals, but now it can be assumed that all chemical elements are involved in physiological processes in varying degrees.…”

Section: Introductionmentioning

confidence: 99%

Statistical analysis of trace metals in the plasma of cancer patients versus controls

Pasha

Malik

Shah

2008

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Statistical analysis of trace metals in the plasma of cancer patients versus controls

Pasha

Malik

Shah

2008

Journal of Hazardous Materials

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“…Although trace metals constitute a minor part of living tissues, they play several vital roles in biological systems such as stabilizers, elements of structure, essential minerals for hormonal function, and cofactors in enzymes [1]. The role of different trace metals in the normal vital activities and initiation of some diseases has long been known, and it is assumed that all chemical elements are involved in physiological processes in varying degrees [2,3]. Any change in the environment as well as in the human body itself can trigger changes in trace metal composition of any organ or tissue, and as a consequence, potentially toxic chemical species may be accumulated, due to which some disease can be produced [4].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Pasha

Malik

Iqbal³

et al. 2008

Biol Trace Elem Res

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Selected trace metals were analyzed in human malignant and nonmalignant (benign) breast tissue samples by the flame atomic absorption spectrophotometric method. In malignant tissues, dominant mean concentrations were revealed by Na, K, Ca, Mg, Fe, Zn, and Al at 927, 552, 231, 61.7, 36.5, 18.3, and 8.94 microg/g, respectively, while the mean metal levels in benign tissues were 903, 435, 183, 63.3, 24.7, 14.5, and 10.1 microg/g, respectively. Average concentrations of Cd, Co, Cr, Cu, Fe, Mn, K, Ca, and Zn were noted to be significantly higher in the malignant tissues compared with the benign tissues. Significantly strong correlations (r > 0.50) in malignant tissues were observed between Mn and Co, Mn and Cd, Cd and Cr, Fe and Mn, Cd and Co, Fe and Co, Mg and Pb, Cd and Fe, Mg and Ni, Pb and Ni, Ni and Sr, and Fe and Pb, whereas, Cd and Co, Cd and Mn, Co and Mg, Co and Mn, Cu and Mn, Co and Ni, Mg and Ni, Cd and Cu, Cd and Ni, Ca and Mg, Mn and Pb, Cu and Ni, Fe and Ni, Cd and Mg, Co and Cu, Cr and Na, and Cd and Cr revealed strong and significant relationships in benign tissues at p < 0.001. Principal component analysis of the metals data yielded six principal components for malignant tissues and five principal components for benign tissues, with considerably different loadings, duly supported by cluster analysis. The study revealed a considerably different pattern of distribution and mutual correlations of trace metals in the breast tissues of benign and cancerous patients.

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“…[2,3] Copper, chromium, iron, and strontium are also essential elements at low levels of intake, but high levels can cause some well-known harmful effects. [4] On the other hand, cadmium, nickel, aluminium, and lead have potential risk in the environment, even in very low concentrations. [4] The biological behavior (bioavailability, effects, and toxicity) of a given element strongly depends on the chemical form in which this element occurs in the biological sample.…”

Section: Introductionmentioning

confidence: 99%

Element Fractionation Analysis for Milk in Its Real Matrix by Inductively Coupled Plasma Optical Emission Spectrometry

Yaşar

Baran

Tokay

2013

Spectroscopy Letters

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Fractionation of elements in food is essential for understanding and prediction of its bioavailability, effects, and toxicity. In the present study, an analytical fractionation scheme for milk samples was developed for the common elements, such as Fe, Cu, Zn, Mn, Mg, Ca, Cr, Ni, Mo, Al, Pb, Sn, V, Ba, Co, and Cd. For this purpose, applying a sequential separation procedure, the protein, lipid, and serum fractions were obtained separately. The recovery percentages were in the range of 96.3-104.0 for the separation of fractions in the synthetic milk. The results achieved in the paper were compared with reported literature data. Additionally, the fractionation pattern for each metal studied was different relating to the origin of milk. Although there were some exceptions, it was seen that Fe, Cu, and Al preferred to be in protein fraction; however, Zn, Mn, Mg, Ca, Cr, Ni, and Mo preferred to be in serum fraction.

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General aspects of trace elements and health

Cited by 39 publications

References 48 publications

Statistical analysis of trace metals in the plasma of cancer patients versus controls

Statistical analysis of trace metals in the plasma of cancer patients versus controls

Comparative Evaluation of Trace Metal Distribution and Correlation in Human Malignant and Benign Breast Tissues

Element Fractionation Analysis for Milk in Its Real Matrix by Inductively Coupled Plasma Optical Emission Spectrometry

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