General anesthetics. 4. Methyl pentahaloethyl and methyl heptahaloisopropyl ethers as anesthetic agents

Fluorine Compounds, Organic

“…These chlorofluoroacetones and some of their derivatives possess herbicidal or fungicidal activity [240][241][242] and are useful intermediates for synthesizing repellants for textile fibers [243,244], specialty polycarbonates [245,246], and inhalation anesthetics [247].…”

Alternative fire suppressant chemicals :

“…CH 3 -O-CF 2 CHBrF has been reported to be a good anesthetic at a volume fraction of 2.5 %. 49 CBrF 2 CF 2 -O-CH 3 has been estimated to have a 2 hour mouse LC 50 of 0.84 % based on a quantitative structure-activity relationships (QSAR). 50 A minimum anesthetic volume fraction of 0.8 % and a minimum lethal volume fraction of 1.5 % have been reported for CHFBrCF 2 CH2-O-CH 3 .…”

“…51 CHF 2 -O-CF 2 CHBrF has been reported to be a good anesthetic in mice at a volume fraction of 1.9 % 52 and CH 3 -O-CF(CF 3 )CBrF 2 has been reported to produce anesthesia in mice with excitation at a volume fraction of 5 %. 49 c. Materials Compatibility. No information is available on material compatibility for the HBFEs; however, compatibilities better than the hydrobromofluoroalkenes and slightly worse than the HBFCs are expected.…”

“…3-carbon compounds (e.g., CH 3 -O-CF 2 CHBr 2 , BP = 55.8 °C) will have marginally acceptable boiling points for use as total flooding agents. The HBCFE CBrF 2 -O-CF 2 CHClF has been estimated to have ∆Hv = 30.3 kJ/mol (115 kJ/kg) at the normal boiling point and a vapor phase heat capacity of 175 J/mol-K (664 J/kg-K) at 25 °C 49.…”

The Invention and Development of Enflurane, Isoflurane, Sevoflurane, and Desflurane

“…Some of the most important work on the synthesis of fluorinated methyl ethyl ethers and fluorinated methyl isopropyl ethers, which resulted in the discovery of enflurane, isoflurane, sevoflurane, and desflurane, has been published. [3][4][5][6] Most of the other work on fluorinated hydro-Additional material related to this article can be found on the ANESTHESIOLOGY Web site. Go to http://www.anesthesiology .org, click on Enhancements Index, and then scroll down to find the appropriate article and link.…”