General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Lee, Yulim; Heo, Jun Young; Ju, Xianshu; Cui, Jianchen; Ryu, Min Jeong; Lee, Min Joung; Hong, Boohwi; Yoo, Sungho; Ahn, Jeonghoon; Kim, Yoon Hee; Ko, Youngkwon; Chung, Woosuk

doi:10.1016/j.neuro.2020.10.012

Cited by 10 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further investigate the significance of mitochondrial dysfunction in the development of neuroinflammation in young mice, mice were injected with 2.5 mg/kg rotenone (i.p. ), a mitochondrial complex I inhibitor, for 3 consecutive days as previously described [ 43 ]. Rotenone was first mixed with dimethyl sulfoxide (DMSO) to a final concentration of 1%, and subsequently diluted using soybean oil (4 mg/ml) [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Lee,

Ju,

Cui

et al. 2024

Heliyon

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Lee,

Ju,

Cui

et al. 2024

Heliyon

Self Cite

View full text Add to dashboard Cite

“…Mitochondria were isolated from the cerebral cortex 5 days after sevoflurane exposures, as previously described ( Lee et al, 2021 ). Mitochondrial fraction was acquired from the cerebral cortex, and seeded in an XF-24 plate (Seahorse Bioscience, United States).…”

Section: Methodsmentioning

confidence: 99%

General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

Cui

Park

et al. 2021

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently.

show abstract

“…The import, folding, and quality control of the mitochondrial proteome encompassing over 1,000 proteins encoded by mitochondrial and nuclear genomes are adjusted by transcriptional programming, a mitochondrial stress response process known as the mitochondrial unfolded protein response (UPR mt ) (8)(9)(10). UPR mt alleviates the abnormal protein accumulation in mitochondria by normalizing mitochondrial protein folding and degradation through initiating the transcriptional activation programming of mitochondrial chaperones and proteases, thereby protecting cells from broad mitochondrial stress (11)(12)(13). Mitochondrial chaperones are capable of helping misfolded proteins return to their normal conformation, and aid newly synthesized proteins in folding accurately, while proteases are capable of degrading useless proteins (14)(15)(16).…”

Section: Original Articlementioning

confidence: 99%

Knowledge mapping of research on the mitochondrial unfolded protein response: a bibliometric and visual analysis

Zhu¹,

Sun²,

Fan³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

Background The mitochondrial unfolded protein response (UPR mt ) is a mitochondria stress response, which exerts a crucial role in maintaining mitochondrial proteostasis during stress. However, there is no bibliometric analyses systematically studied this field which could comprehensively review research trends, evaluate publication performances and provide future perspectives. Methods Articles investigating UPR mt published between 1994 and 2021 were downloaded from the Core Collection of the Web of Science (WOS). CiteSpace and VOSviewer bibliometric software were applied for bibliometric and visual analyses. Results A total of 2,073 papers researching UPR mt were retrieved. According to the published number of papers, the field of UPR mt research has gone through its infancy (after 2000) and rapid growth (after 2021) phases. The United States and China contributed the most to UPR mt research. Regarding the distribution of institutions, Harvard University was the most influential institution. The most prolific authors are Johan Auwerx and CM Haynes. PLoS One is the most extensive journal in the field of UPR mt research, while the Cell Death and Differentiation journal had the greatest impact among the most-authored journals. Moreover, biochemistry/molecular biology, and cell biology are the largest subject areas. UPR mt research is mainly categorized as UPR mt , transcription, endoplasmic reticulum (ER) stress, lipotoxicity, mitophagy, inflammation, skeletal muscle, hypoxia, apoptosis, mitochondrial dysfunction, neurodegeneration, mitochondrial permeability transition, and integrated stress response. Conclusions At present, research on UPR mt is booming. Further strengthening the cooperation and exchanges between countries, institutions, and authors in the future will surely promote the development of this field.

show abstract

General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Cited by 10 publications

References 43 publications

Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

Knowledge mapping of research on the mitochondrial unfolded protein response: a bibliometric and visual analysis

Contact Info

Product

Resources

About