Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation

“…We have previously utilized this model and described similar defects in recognition memory. 13 In comparison to other studies, a onetime 0.33 mg/kg administration did not detect spatial memory impairment in young mice, 46 and 5 days of 0.25 mg/kg treatment resulted in reduced NOR performance, 15 reporting on no other behavioral changes (no others measured). Administration of 0.25–0.75 mg/kg for 7 sequential days appears to consistently induce cognitive decline across a broad range of cognitive domains, 47–50 with reduced spatial and recognition memory reported (Morris water maze, y maze NOR) however OF performance was only quantified (and found to be influenced by LPS) by Oz et al 50 Similar results were also reported in a study in which the seven injections were administered on alternative days (Water maze and Y maze), 51 again OF was not reported.…”