2022
DOI: 10.1590/s1678-9946202264012
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Gene-Xpert Ultra for the diagnosis of extrapulmonary tuberculosis in children and adolescents

Abstract: This prospective study describes the use of Gene-Xpert Ultra for the diagnosis of extrapulmonary tuberculosis (EPTB) in children and adolescents, in Rio de Janeiro, Brazil. Eighteen patients were studied; the final diagnosis of EPTB was established in 13 (72%). Gene-Xpert Ultra results showed detection in 10/13 (77%) of EPTB cases (7 of these 10 with trace-positive results). Gene-Xpert Ultra proved to be a promising method for the diagnosis of childhood EPTB.

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Cited by 3 publications
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“…Our study confirms the results of Aurilio's study in Brazil [12] regarding whether the test was useful in children and adolescents; we identified two cases of pleural TB in adolescents, one case of neuromeningeal TB in a 1-year-old child that resulted in death, and one case of digestive TB in a 3-year-old child for whom a diagnosis of sarcoidosis had been made on non-necrotizing granulomatous lymphadenitis. Despite the limited number of pediatric patients, our study contributes to show the usefulness of the trace result given the difficult diagnosis of EPTB in children.…”
Section: Discussionsupporting
confidence: 89%
“…Our study confirms the results of Aurilio's study in Brazil [12] regarding whether the test was useful in children and adolescents; we identified two cases of pleural TB in adolescents, one case of neuromeningeal TB in a 1-year-old child that resulted in death, and one case of digestive TB in a 3-year-old child for whom a diagnosis of sarcoidosis had been made on non-necrotizing granulomatous lymphadenitis. Despite the limited number of pediatric patients, our study contributes to show the usefulness of the trace result given the difficult diagnosis of EPTB in children.…”
Section: Discussionsupporting
confidence: 89%