Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Ghorbani, Zahra; Shakiba, Mohammad Reza; Rezavand, Negin; Rahimi, Ziba; Vaisi-Raygani, Asad; Rahimi, Zohreh; Shakiba, Ebrahim

doi:10.1080/10641955.2020.1849274

Cited by 8 publications

(10 citation statements)

References 28 publications

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“…In the study by Rezende et al, the relationship between VDR polymorphisms ( FokI , ApaI , and BsmI ) and the occurrence of PE and GH (154 with GH, 162 with PE, and 213 healthy pregnant women) was analyzed. The frequency of all three VDR polymorphisms in the PE, GH, and healthy pregnant groups was similar (all p > 0.05) [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women

et al. 2021

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For the first time in the Polish population, we aimed to investigate associations between the VDR gene single-nucleotide polymorphisms (SNPs) BsmI (rs15444410), ApaI (rs7975232), FokI (rs19735810), and TaqI (rs731236) and the development of preeclampsia (PE). A case–control study surveyed 122 preeclamptic and 184 normotensive pregnant women. The polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was performed to examine the maternal VDR FokI, BsmI, TaqI, and ApaI polymorphisms. The VDR BsmIAA homozygous genotype was statistically significantly more frequent in preeclamptic women compared to the control group (p = 0.0263), which was also associated with a 2-fold increased risk of PE (OR = 2.06, p = 0.012). A correlation between the VDR BsmI polymorphism with systolic and diastolic blood hypertension was noted. Furthermore, 3-marker haplotype CTA (TaqI/ApaI/BsmI) was associated with significantly higher systolic (p = 0.0075) and diastolic (p = 0.0072) blood pressure. Association and haplotype analysis indicated that the VDR BsmI A allele could play a significant role in the PE pathomechanism and hence could be a risk factor for PE development in pregnant Polish women. These results indicate the importance of the VDR BsmI polymorphism and reveal that this variant is closely associated with a higher predisposition to hypertension.

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Section: Discussionmentioning

confidence: 99%

The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women

et al. 2021

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“…In some but not all studies, the GC polymorphism was significantly associated with lower serum levels of 25 (OH)-D. The association of GC polymorphism with 25 (OH)-D is ethnic dependent as it has been reported in some specific ethnic populations such as Arab and South Asian populations. 8 In SCD patients, metabolic demands on the liver might reduce the capacity of vitamin D binding protein synthesis. 7 Lower levels of 25 (OH)-D levels were associated with decreased expression of GC and VDR genes.…”

Section: Discussionmentioning

confidence: 99%

“…The FokI T>C (rs2228570) in exon 2 and the TaqI T>C (rs731236) in exon 9 of the VDR gene were detected by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method as previously described 12 . The GC rs7041 was identified by the PCR‐RFLP method using the HaeIII restriction enzyme 8 …”

Section: Methodsmentioning

confidence: 99%

“…The carrier of vitamin D and its metabolites in the circulation is vitamin D binding protein that is encoded by a gene named group‐specific component (GC). The active form of vitamin D, 1, 25 (OH) 2‐D3 binds to the nuclear vitamin D receptor (VDR) that performs a heterodimer with the retinoid‐X receptor (RXR) and exerts the vitamin D function through influence gene transcription in target tissues 8 . Most of the roles of vitamin D3 are through VDR‐RXR that activates VDR response elements in the promoter region of about 900 genes.…”

Section: Introductionmentioning

confidence: 99%

“…The active form of vitamin D, 1, 25 (OH) 2-D3 binds to the nuclear vitamin D receptor (VDR) that performs a heterodimer with the retinoid-X receptor (RXR) and exerts the vitamin D function through influence gene transcription in target tissues. 8 Most of the roles of vitamin D3 are through VDR-RXR that activates VDR response elements in the promoter region of about 900 genes. Some non-genomic rapid actions of vitamin D3 are mediated by the surface receptors.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

Hama

Shakiba

Rahimi

et al. 2021

Clinical Laboratory Analysis

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Introduction Sickle cell disease (SCD) patients are susceptible to the development of vitamin D deficiency (VDD). Vitamin D through binding to vitamin D receptor (VDR) exerts its function and affects gene transcription in target tissues. VDR gene variants affect bone mineral density. Methods In a case‐control study, 101 SCD patients including 61 sickle cell anemia (SCA), 39 S/β‐thalassemia, and 1 HbS/HbD (SD) along with 110 healthy individuals from Kurdistan of Iraq were studied. The lipid profile, vitamin D level, FokI, and TaqI variants of VDR and group‐specific component (GC) were detected using the standard enzymatic method, the immunodiagnostic systems limited EIA kit and PCR‐RFLP methods, respectively. Results Around 93% and 82% of SCA and S/β‐thalassemia patients, respectively, had VDD compared to 83% of healthy individuals. Severe VDD (<10 ng/ml) was detected in 78.7% of patients with HbSS. Plasma levels of total cholesterol, HDL‐C, and LDL‐C in SCD patients were significantly lower compared to controls. Vitamin D levels were negatively correlated to TG and positively correlated to total cholesterol and HDL‐C. The frequencies of the C allele of FokI were 81.7% (p = 0.003), 80.3% (p = 0.034), and 84.6% (p = 0.011) in all SCD, SCA, and S/β‐thalassemia patients, respectively, compared to 69.1% in controls. However, no significant difference was detected comparing the frequencies of VDR TaqI and GC polymorphisms between SCD patients and controls. Conclusion In the present study, we found hypocholesterolemia, high prevalence of VDR FokI C allele, and low vitamin D levels among children and adults with SCD from Kurdistan of Iraq.

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COVID‐19 and renin angiotensin aldosterone system: Pathogenesis and therapy

Babajani

Kakavand

Mohammadi

et al. 2021

Health Science Reports

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Aims The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binds to the ACE2 component of the renin‐angiotensin aldosterone system (RAAS) and infects the human cells. The aims of the present review were to look at the role and alteration of the RAAS components in SARS‐CoV‐2 infection, therapeutic approaches, and clinical trials in this field. Methods We surveyed the literature (PubMed, Web of Science, and Scopus) till August 18, 2021, and 59 published papers regarding the components of the RAAS and their role and alterations in SARS‐CoV‐2 infection along with various COVID‐19 therapies based on the RASS components were included in the study. Results ACE inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor inhibitors are agents that significantly enhance the ACE2 and Ang‐(1‐7) levels, which can be suggestive for their role as therapeutics against SARS‐CoV‐2 infection. Beta‐adrenergic blockers, which negatively regulate renin release from juxtaglomerular cells, and vitamin D, as a regulator of the RAAS and renin expression, are proposed therapeutics in the treatment of COVID‐19. Some antihyperglycemic agents could be potentially protective against COVID‐19‐induced lung injury. Also, the inhibition of the Janus kinase/signal transducer and activator of the transcription pathway as a potential treatment for COVID‐19 has been suggested. Finally, resveratrol, an antioxidant that can suppress Ang II, has been suggested as an adjunct to other therapies. Conclusion Regarding the suggested potential therapies for COVID‐19, there are many clinical trials whose results might change the treatment strategies of SARS‐CoV‐2 infection. So, the results of well‐organized clinical trials on the efficacy and safety of the mentioned agents in the treatment of COVID‐19 will be useful in the management and therapy of the disease.

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Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Cited by 8 publications

References 28 publications

The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women

The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women

Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

COVID‐19 and renin angiotensin aldosterone system: Pathogenesis and therapy

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