Gene Therapy and its Application in Dentistry

Khandelwal, Anshul; Sikdar, Sarbani Deb; Diwan, Raj Kumar; Ghom, Savita; Ghom, Anil; Kailasam, S

doi:10.5005/jp-journals-10011-1066

Cited by 3 publications

(6 citation statements)

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“…8 Physical vectors includes electrophoration, microinjection, and use of ballistic particle. 6 Chemical vectors include calcium particles, lipids, and protein complexes. Electrophoration: In this method, the DNA is transferred into the desired cells through pores created by the passage of electric current.…”

Section: Types Of Vector For Gene Therapymentioning

confidence: 99%

“…2,5 In one study, in vivo transfer of mesenchymal stem cells expressing BMP-2 results in osteogenesis. 6 Michigan research group has found nonosteogenic fibroblasts (gingiva, dental pulp) express BMP-7 gene after being infected with an adenoviral vector. The BMPs are agents well established in induction of both orthotopic and ectopic bone formation.…”

Section: Applications In Dentistrymentioning

confidence: 99%

“…In another study, the gene therapy utilizing plasmid pCIA-P vector encoding pac gene of S. mutans showed resistance to caries in rats by targeted salivary gland immunization. 4,6 • Keratinocyte: The cells presents in the skin and oral mucosa are the keratinocytes. These cells are vulnerable to many gene disorders, such as autoimmune conditions.…”

Section: Applications In Dentistrymentioning

confidence: 99%

“…This site can also be used for gene therapy for systemic autoimmune disorders, such as Sjögren's and Mikulicz syndrome. 2,4,6 A study showed that gene therapy using interleukin-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy.…”

Section: Applications In Dentistrymentioning

confidence: 99%

“…5 Gene therapy in recent days has several applications in dentistry, which includes bone repair, treatment of salivary gland diseases, autoimmune conditions, potentially malignant disorders, pain management, DNA vaccinations (periodontal diseases, caries), and autoimmune mucosal disorders. 2,4,6 According to the US Food and Drug administration, the basic principle of gene therapy is to replace a person's defective genes with new ones in order to cure a disease. 7 The new gene inserted will modify the clinical course of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Gene Therapy as a Management Tool in Dentistry

2017

International Journal of Advanced and Integrated Medical Sciences

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Introduction Gene therapy is an emerging field of biomedicine that has gained significant attention in dentistry too. Various research programs are being carried out to understand the cellular and molecular bases of every disease. Since most of the conventional therapeutic approaches are not so satisfactory in treating a disease completely, currently there is an increasing focus on gene therapy to treat a wide variety of inherited and acquired diseases. This new era of gene therapy can be accomplished in the medicine field primarily to replace or cure defective genes and treat a wide variety of gene disorders, whether the disease is due to single or multiple defective genes. It has a variety of applications in the field of dentistry like salivary gland disorders, autoimmune conditions, potentially malignant disorders, etc. The sites, such as minor salivary glands present in the labial and buccal mucosa and also mucosal keratinocytes are potential targets for gene therapy, since these structures are superficial and offer minimal hindrance to the gene therapy procedure. The present article discusses the basic principles of gene therapy, its applications in the field of dentistry, limitations, and disadvantages. How to cite this article Gupta P, Thakur J. Gene Therapy as a Management Tool in Dentistry. Int J Adv Integ Med Sci 2017;2(3):149-154.

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Section: Types Of Vector For Gene Therapymentioning

confidence: 99%

Section: Applications In Dentistrymentioning

confidence: 99%

Section: Applications In Dentistrymentioning

confidence: 99%

Section: Applications In Dentistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gene Therapy as a Management Tool in Dentistry

2017

International Journal of Advanced and Integrated Medical Sciences

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A Review on Thermography in Dentistry

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2018

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The study and application of biothermal process to assess health or disease is termed as Thermology and the imaging and visual evaluation of these thermal changes is termed "Thermography." Over the years, a variety of devices have been employed to measure body temperature. More recently with the advancement of technology, thermography as a tool has progressed into a beneficiary device in diagnosis. Thermography is a non-contact, non-destructive and non-invasive investigative method that utilises the heat from an object to detect, display and record thermal patterns and temperatures across the surface of the object. Variation in temperature distribution is attributed to variation in blood supply in various pathologies. Thermography is used to detect malignancies of the maxillofacial region, vitality of teeth, craniofacial neuralgia, TMJ disorders and chronic orofacial pain to list a few. This article highlights the basic principles of thermography and its beneficial role in maxillofacial medicine. BACKGROUNDBeing a homeotherm humans are capable of maintaining a constant temperature of the body, which may be different from surrounding temperature. 1 The body of homeotherms can be divided into the inner core and the outer periphery. The core temperature is preserved within a narrow limit (Approximately 42-33 0 C). 2 Regulation of inner core temperature is essential for normal performance of human body. Change in the core temperature by a few degrees is considered as a clear indication of probable illness. 1 As the quantity of blood circulation at various parts of the skin differs, the temperature changes accordingly. Therefore, diseases affect the flow of blood and also result in irregularities in distribution of temperature and when assessed they will yield genuine diagnostic data. 3 From the ancient past, bodily heat was considered as a major symbol of health and implementation of temperature determination along with thermal imaging. As time advanced an array of devices have been employed such as thermometers, thermistors, thermocouples and liquid crystal imaging systems for determining the body temperature. 4 In this review we aim to discuss history, types of thermography and general requirements and guidelines and also highlighted the probable uses of thermography in dentistry.

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