Gene regulation by steroid hormones

Beato, Miguel

doi:10.1016/0092-8674(89)90237-7

Cited by 3,347 publications

(1,423 citation statements)

References 108 publications

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“…Steroid receptors belong to a class of ligand-activated nuclear receptors that include thyroid hormone, retinoic acid, retinoid X, and 15-deoxy-∆ 12,14 prostaglandin J2 receptors (Evans, 1988;Beato, 1989;Glass, 1994;Mangelsdorf et al, 1995). These receptors regulate gene transcription by binding to specific sites on DNA.…”

Section: Steroid Hormone Receptors Belong To the Nuclear Receptor Familymentioning

confidence: 99%

Steroid receptor phylogeny and vertebrate origins

Baker

1997

Molecular and Cellular Endocrinology

110

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Section: Steroid Hormone Receptors Belong To the Nuclear Receptor Familymentioning

confidence: 99%

Steroid receptor phylogeny and vertebrate origins

Baker

1997

Molecular and Cellular Endocrinology

110

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“…The primary structure of the MR and GR has been elucidated, the nucleotide sequence that is essential for some of the hormone responsive elements is known and recent studies have even focussed on the two and three dimensional representation of the steroid protein-DNA complex (see for reviews e.g. Gustafsson et al, 1987;Beato, 1989;Schwabe and Rhodes, 1991;Gronemeyer, 1992;King, 1992). Important for this progress was the purification of the GR in the early eighties (Westphal and Beato, 1980;Wrange et al, 1984).…”

Section: Primary Structurementioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

367

168

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“…Transcriptional upregulation by the AR occurs through homodimer binding of the receptor to distinct DNA sequences (Cato et al, 1987;Ham et al, 1988;Beato, 1989). This takes place alongside interaction of the receptor with basal transcription factors such as TFIIF and the TATA-box binding protein (McEwan and Gustafsson, 1997) or with coactivators that potentiate its activity (Voegel et al, 1996;Yeh and Chang, 1996).…”

Section: Introductionmentioning

confidence: 99%

Rapid signalling by androgen receptor in prostate cancer cells

Peterziel¹,

Mink²,

Schonert³

et al. 1999

Oncogene

230

157

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Androgens are important growth regulators in prostate cancer. Their known mode of action in target cells requires binding to a cytoplasmic androgen receptor followed by a nuclear translocation event and modulation of the expression of speci®c genes. Here, we report another mode of action of this receptor. Treatment of androgen responsive prostate cancer cells with dihydrotestosterone leads to a rapid and reversible activation of mitogen-activated protein kinases MAPKs (also called extracellular signal-regulated kinases or Erks). Transient transfection assays demonstrated that the androgen receptor-mediated activation of MAP kinase results in enhanced activity of the transcription factor Elk-1. This action of the androgen receptor di ers from its known transcriptional activity since it is rapid and insensitive to androgen antagonists such as hydroxy¯utamide or casodex. Biochemical studies as well as analyses with dominant negative mutants showed the involvement of kinases such as MAPK/Erk kinase, phosphatidyl-inositol 3-kinase and protein kinase C in the androgen receptormediated activation of MAP kinase. These results demonstrate a novel regulatory action of the androgen receptor and prove that in addition to its known transcriptional e ects, it also uses non-conventional means to modulate several cellular signalling processes.

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Gene regulation by steroid hormones

Cited by 3,347 publications

References 108 publications

Steroid receptor phylogeny and vertebrate origins

Steroid receptor phylogeny and vertebrate origins

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Rapid signalling by androgen receptor in prostate cancer cells

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