Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus

Flekač, Milan; Škrha, J; Hilgertová, J; Lacinová, Z; Jarolímková, M

doi:10.1186/1471-2350-9-30

Cited by 137 publications

(113 citation statements)

References 35 publications

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“…It must be noted that previous studies did not find an association with CAT and T1DM [28,29]. CAT has been shown to be associated with several other disease conditions.…”

Section: Discussionmentioning

confidence: 73%

“…When a genetically engineered derivative of the peroxisomal antioxidant enzyme catalase (CAT-SKL), induced by intracerebroventricular injection of Aβ [25][26][27][28][29][30][31][32][33][34][35] in the mature rat brain, it is able to reduce the toxicity of the accumulated beta-amyloid in the brain [44]. Free radical mediated oxidative stress have long been considered to be involved in the pathogenesis of diabetic complications but could they also because protein aberrations and some pathology in cells [45].…”

Section: Discussionmentioning

confidence: 99%

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Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus

Houldsworth¹,

Hodgkinson²,

Demaine³

et al. 2016

JED

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“…It must be noted that previous studies did not find an association with CAT and T1DM [28,29]. CAT has been shown to be associated with several other disease conditions.…”

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus

Houldsworth¹,

Hodgkinson²,

Demaine³

et al. 2016

JED

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“…A case-control study indicated that homozygosity for the SOD2 rs4880 Val allele is associated with an increased risk of DN, thus supporting the hypothesis that oxidative stress contributes to this severe long-term complication in diabetic patients (Môllsten et al, 2007). Other studies showed that oxidative stress in DM1 and DM2 can be accelerated not only due to increased ROS production caused by hyperglycemia, but also by the reduced ability of the antioxidant defense system caused at least partly by deleterious SNPs of some scavenger enzymes (Flekac et al, 2008). The presence of the TT (Val/Val) homozygous genotype of the SOD2 gene was associated with poorer diabetes control in comparison with CT (Ala/Val) and CC (Ala/Ala) genotypes.…”

Section: Antioxidant Enzymes: Superoxide Dismutase (Sod) and Catalasementioning

confidence: 88%

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

Garcı́a¹,

Wolff²,

Araya³

et al. 2011

Medical Complications of Type 2 Diabetes

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“…17 Moreover, several single nucleotide polymorphisms (SNPs) in the CAT gene have been found to be associated with diabetic nephropathy and neuropathy. 18,19 However, it is unknown whether there is an association between antioxidant gene polymorphisms and clinical outcomes of acute kidney injury (AKI). Therefore, in the current study, we studied the association between MnSOD, CAT and GPX1 gene polymorphisms and clinical outcomes of AKI.…”

Section: Introductionmentioning

confidence: 99%

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

Kıdır

Yiğit

et al. 2016

Renal Failure

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Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI). Materials and methods Ninety AKI patients and 101 healthy volunteers were included in the study. Determination of MnSOD rs4880, GPX1 rs1050450 and CAT rs769217 polymorphisms was performed using real-time polymerase chain reaction amplification. The duration of hospitalization of AKI patients, dialysis and intensive care requirements, sepsis, oliguria and in-hospital mortality rates were assessed. Results The MnSOD, GPX1 and CAT genotypes and allele frequencies of AKI patients did not differ significantly from those of healthy controls. In patients with a T allele in the ninth exon of the CAT gene, intensive care requirements were greater than those of patients with the CC genotype (p ¼ 0.04). In addition, sepsis and in-hospital mortality were observed significantly more frequently in patients with a T allele in the ninth exon of the CAT gene (p ¼ 0.03). Logistic regression analysis determined that bearing a T allele was the primary determinant of intensive care requirements and in-hospital mortality, independent of patient age, gender, presence of diabetes and dialysis requirements (OR 6.10, 95% CI 1.34-27.81, p ¼ 0.02 and OR 10.25, 95% CI 1.13-92.80, p ¼ 0.04, respectively). Conclusion Among AKI patients in the Turkish population, hospital morbidity and mortality were found to be more frequent in patients bearing a T allele of the rs769217 polymorphism of the CAT gene.

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Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus

Cited by 137 publications

References 35 publications

Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus

Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury

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