Gene polymorphisms and serum levels of TL1A in patients with rheumatoid arthritis

Abstract

Recent findings showed elevated expression of tumor necrosis factor (TNF)‐like ligand 1A (TL1A) in rheumatoid arthritis (RA) patients and arthritis mice. However, whether TL1A gene polymorphisms may correlate with RA susceptibility needs to be discussed. This case‐control study was performed on 350 RA patients and 556 healthy subjects to identify TL1A genetic variants (rs3810936, rs6478109, and rs7848647) and their possible association with TL1A levels, susceptibility to and severity of RA. Odds ratio and 95% confidence interval were calculated to represent the correlation between TL1A polymorphisms and RA. The TL1A serum levels were evaluated. Results showed that frequencies of TC, TT + TC genotypes of rs3810936, rs7848647 in RA patients were significantly lower in RA patients compared with controls. Patients with C allele showed more severe disease course (disease activity index: erythrocyte sedimentation rate, rheumatoid factor) than in carriers of T allele. However, the allele or genotype frequencies of rs6478109 were not associated with RA. In addition, TL1A genetic variants conferred higher TL1A levels in RA patients compared with controls. In conclusion, these findings indicated an association between TL1A rs3810936, rs7848647 variation and the susceptibility of RA in a sample of Chinese individuals, and TL1A may correlate with severity of RA.

Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis

“…A growing body of evidence suggests that TL1A is closely linked to the process of inflammation and fibrosis diseases [30][31][32]. TL1A is a member of the TNF family, which can bind to death receptor 3 (DR3) [33], and can enhance T cell proliferation and cytokine production [34].…”

Association between TL1A gene polymorphisms and systemic lupus erythematosus in a Chinese Han population

“…Amplification was conducted by a total of 10 μl reacting kits, including 5 μl Master mix, 0.1 μl Assay mix, 0.9 μl ultrapure water as well as 4 μl extracted DNA. All genotyping was done on ABI 7,300 system, as previously reported (Yuan, Wang, Huang, et al, ; Yuan, Wang, Su, et al, ).…”

“…Studies reported that serum levels of TL1A and TL1A expression in synovial fluid of RA patients were elevated as compared with that in osteoarthritis patients (X. Sun et al, ; Yuan, Wang, Su, Xu, & Huang, ; Yuan, Wang, Huang, et al, ). TL1A expression in RA patients' serum was related to the levels of rheumatic factor and anti‐citrullinated protein (X.…”

Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review

“…TL1A levels in serum and synovial fluid were higher in RA patients when compared to that in healthy controls and correlated with expression of rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), as well as disease activity ( Table 1 ) ( 63 , 68 , 69 ). RF and anti-CCP antibodies are promising disease markers for early diagnosis and prognosis of RA ( 63 ).…”