Association between TL1A gene polymorphisms and systemic lupus erythematosus in a Chinese Han population

Abstract

Our previous studies showed elevated tumor necrosis factor-like ligand 1 aberrance (TL1A) expression in systemic lupus erythematosus (SLE). However, TL1A polymorphisms with SLE susceptibility remain to be elucidated. In addition, we made meta-analysis to evaluate the relationship of TL1A polymorphisms and autoimmune diseases owing to inconsistent results. The present research was carried out by 404 SLE, 150 primary Sjogren's syndrome (pSS) patients, and 574 healthy individuals. Three TL1A polymorphisms (rs3810936, rs6478109, rs7848647) were genotyped using TaqMan genotyping assay. Then, the metaanalysis was performed by collecting the present case-control study and previously published research. Results showed that genotypes of rs3810936, rs7848647 were different between SLE patients and healthy controls, whereas no significant association was observed in the three polymorphisms and pSS patients.Genotypes distribution of rs6478109, rs7848647 were strongly related to lupus nephritis within SLE (p = 0.004, p = 0.011), respectively. Moreover, combined meta-analysis consisted of ten comparative research involving 4,305 patients and 5,600 controls. An association between autoimmune diseases and rs6478109 polymorphism was found. Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus. K E Y W O R D Slupus, meta-analysis, single-nucleotide polymorphism, susceptibility, TL1A

Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review

“…Studies indicated that expression of plasma TL1A was elevated in SLE patients and was positively correlated with disease activity score ( Table 1 ) ( 51 ). In a meta-analysis, the authors found that TL1A gene polymorphisms (rs3810936, rs7848647) may associate with SLE susceptibility ( Table 2 ) ( 88 ). There are few studies about TL1A and SLE, and more evidence is needed to elucidate the role of TL1A in SLE pathogenesis.…”

“…(88). There are few studies about TL1A and SLE, and more evidence is needed to elucidate the role of TL1A in SLE pathogenesis.…”

Association of Immune-Related Genetic and Epigenetic Alterations with Lupus Nephritis

“…Most of them are related to the following vital pathways of LN [ 6 , 42 ]: complements, phagocytosis, the clearing of ICs (FCGR2B [ 43 ], FCGR3B [ 43 ], FCGR2A [ 43 ], FCGR3A [ 44 ], PADI4 [ 45 ]), interferon pathways (IRF5 [ 46 ], STAT4 [ 24 , 47 , 48 ], IFN3/4 [ 49 ], etc. ), T and B cell development and signaling (TNFSF4 [ 42 ], TL1A [ 50 ], IKZF1 [ 51 ]), etc. There were also some protective haplotypes in non-MHC regions, such as ACA of P2X7R gene [ 52 ] and GTTCTAA of CD40 gene [ 53 ].…”

Unresolved Questions on the Relationship Between EZH2 and Lupus: Comment on the Article by Rohraff et al

“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by a range of manifestations, such as kidney, bone, and skin damage and impairment of immune system regulation. Cumulative evidence has shown that both genetic and environmental factors lead to an imbalance in autoimmunity, which contributes to SLE pathogenesis (1).…”