Gene polymorphism and levels of pro-inflammatory cytokines in plasma and synovial fluid of patients with posttraumatic knee osteoarthritis

Vnukov, V. V.; Krolevets, I. V.; Panina, Svetlana; Milutina, N. P.; Ananyan, A. A.; Sagakyants, Aleksandr B.; Zabrodin, M. A.

doi:10.1134/s2079057016030152

Cited by 4 publications

(6 citation statements)

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“…The current case–control study identified no significant correlation between TNF-α G-308A and OA risk. This result is consistent with some of the previous studies [ 12 , 13 , 15 , 16 , 18 – 20 ]. However, other studies have indicated that TNF-α G-308A is correlated with OA risk [ 10 , 14 , 17 , 21 , 22 ].…”

Section: Discussionsupporting

confidence: 94%

“…Twelve studies have currently investigated the association between G-308A polymorphism and knee OA [10,[12][13][14][15][16][17][18][19][20][21][22]. However, no satisfactory consensus has been reached.…”

Section: Introductionmentioning

confidence: 99%

“…One study considered that the minor allele (A allele) carriers had a lower risk of knee OA [17]. Seven studies also showed a null association between TNF-α G-308A polymorphism and knee OA [12,13,15,16,[18][19][20]. The trial sequential analysis (TSA) provided an opportunity to evaluate whether the most recent conclusions are supported by the current cumulative samples [23].…”

Section: Introductionmentioning

confidence: 99%

“…The trial sequential analysis (TSA) provided an opportunity to evaluate whether the most recent conclusions are supported by the current cumulative samples [23]. The sample size provided by the currently available studies is only 1,533, 1,647, and 600 in Asians, Caucasians, and Egyptians [10,[12][13][14][15][16][17][18][19][20][21][22], which is not enough for obtaining a decisive conclusion. Thus, this study aims to conduct a case-control study to validate the association between TNF-α G-308A polymorphism and knee OA in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

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Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

et al. 2021

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Background Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained. Objective This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA. Methods Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren–Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue. Results A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62–1.15) in the recessive model] in the present case–control study, and analysis of other genetic models showed a similar trend. After adding the critical case–control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56–4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion. Conclusions The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

et al. 2021

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“…1. A total of eleven studies in eight publications, including eight case-control studies [23][24][25][26][27][28][29] for TNF-α −308 G > A polymorphism (1194 cases and 1444 controls) and casecontrol three studies 26 , 27 for TNF-α -238G > A (360 cases and 525 controls) were selected for this meta-analysis. Table 2 summarizes the characteristics of the studies included in our analysis.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

Sobhan¹,

Mahdinezhad-Yazdi²,

Aghili³

et al. 2018

Journal of Orthopaedics

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Development and optimization of a novel drug free nanolipid vesicular system for treatment of osteoarthritis

Afify

Dein

Elsadek

et al. 2017

Drug Development and Industrial Pharmacy

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Gene polymorphism and levels of pro-inflammatory cytokines in plasma and synovial fluid of patients with posttraumatic knee osteoarthritis

Cited by 4 publications

References 14 publications

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

Development and optimization of a novel drug free nanolipid vesicular system for treatment of osteoarthritis

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Gene polymorphism and levels of pro-inflammatory cytokines in plasma and synovial fluid of patients with posttraumatic knee osteoarthritis

Cited by 4 publications

References 14 publications

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis

Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

Development and optimization of a novel drug free nanolipid vesicular system for treatment of osteoarthritis

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Product

Resources

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Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis