Gene Expression Studies in Major Depression

Mehta, Divya; Menke, Andreas; Binder, Elisabeth B.

doi:10.1007/s11920-010-0100-3

Cited by 81 publications

(51 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the presented study, we determined higher levels of KDR gene and its protein in the peripheral blood cells. The expression in the periphery may reflect expression in brain cells, as has been previously described by Mehta et al (2010). Data from experiments with peripheral blood cells may play an important role, given that involvement of systemic components and their affect on brain are discussed and not excluded.…”

Section: Discussionmentioning

confidence: 72%

Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder

Gałecki

Orzechowska

Berent

et al. 2013

Journal of Affective Disorders

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 72%

Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder

Gałecki

Orzechowska

Berent

et al. 2013

Journal of Affective Disorders

View full text Add to dashboard Cite

“…One of them has focused on gene expression to integrate genomic activity and environmental effects (Gerhold et al, 2002). Most studies on transcriptional profiling in affective disorders have explored RNA derived from postmortem brain tissue (Mehta et al, 2010). However, agonal and postmortem factors may influence gene expression, and lacking access to brain tissue contradicts its use as biomarker (Tomita et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

Menke

Arloth

Pütz

et al. 2012

Neuropsychopharmacol

Self Cite

146

126

View full text Add to dashboard Cite

Although gene expression profiles in peripheral blood in major depression are not likely to identify genes directly involved in the pathomechanism of affective disorders, they may serve as biomarkers for this disorder. As previous studies using baseline gene expression profiles have provided mixed results, our approach was to use an in vivo dexamethasone challenge test and to compare glucocorticoid receptor (GR)-mediated changes in gene expression between depressed patients and healthy controls. Whole genome gene expression data (baseline and following GR-stimulation with 1.5 mg dexamethasone p.o.) from two independent cohorts were analyzed to identify gene expression pattern that would predict case and control status using a training (N ¼ 18 cases/18 controls) and a test cohort (N ¼ 11/13). Dexamethasone led to reproducible regulation of 2670 genes in controls and 1151 transcripts in cases. Several genes, including FKBP5 and DUSP1, previously associated with the pathophysiology of major depression, were found to be reliable markers of GR-activation. Using random forest analyses for classification, GR-stimulated gene expression outperformed baseline gene expression as a classifier for case and control status with a correct classification of 79.1 vs 41.6% in the test cohort. GR-stimulated gene expression performed best in dexamethasone non-suppressor patients (88.7% correctly classified with 100% sensitivity), but also correctly classified 77.3% of the suppressor patients (76.7% sensitivity), when using a refined set of 19 genes. Our study suggests that in vivo stimulated gene expression in peripheral blood cells could be a promising molecular marker of altered GR-functioning, an important component of the underlying pathology, in patients suffering from depressive episodes.

show abstract

“…There is also strong evidence that peripheral molecules can also affect neurons. Peripheral blood cells share more than 80% of the transcription with 9 tissues, including the brain [39]. …”

Section: Discussionmentioning

confidence: 99%

Manganese Superoxide Dismutase Gene Expression and Cognitive Functions in Recurrent Depressive Disorder

Talarowska¹,

Orzechowska²,

Szemraj

et al. 2014

Neuropsychobiology

View full text Add to dashboard Cite

Background: Recent studies have revealed that recurrent depressive disorders (rDD) are linked with dysregulation of the immune system. Previous studies have found that manganese superoxide dismutase (MnSOD, SOD2) may be a key inflammatory enzyme involved in this disorder. The purpose of this study was to determine the mRNA and protein levels of MnSOD in patients with rDD and to define the relationship between serum MnSOD levels and cognitive performance. Methods: The study comprised 236 subjects, which included patients with rDD (n = 131) and healthy subjects (n = 105, healthy control group, HC). Assessment of cognitive function was based on performance on the Trail Making test (TMT), the Stroop test, the Verbal Fluency test (VFT) and the Auditory Verbal Learning test (AVLT). Results: MnSOD gene expression at mRNA and protein level was significantly lower in rDD patients than in the HC group (p < 0.01). In the rDD and HC groups separately, there were no statistically significant associations between mRNA and protein expression levels of the MnSOD and psychological tests. In the total study group (n = 236), there was a statistically significant correlation between both MnSOD gene levels and the following tests (p < 0.01): the TMT parts A and B (negative correlation), the Stroop test parts RCNb (reading color names in black) and NCWd (naming color of word - different; negative correlation), the VFT (positive correlation) and the AVLT (positive correlation). Conclusions: Our study provides evidence that the MnSOD enzyme-coding gene and MnSOD expression are important for the regulation of cognitive functioning.

show abstract

Gene Expression Studies in Major Depression

Cited by 81 publications

References 55 publications

Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder

Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder

Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

Manganese Superoxide Dismutase Gene Expression and Cognitive Functions in Recurrent Depressive Disorder

Contact Info

Product

Resources

About