Manganese Superoxide Dismutase Gene Expression and Cognitive Functions in Recurrent Depressive Disorder

Talarowska, Monika; Orzechowska, Agata; Szemraj, Janusz; Su, Kuan‐Pin; Maes, Michaël; Gałecki, Piotr

doi:10.1159/000363340

Cited by 27 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced levels of antioxidants enzymes, such glutathione peroxidase and SOD have been described in MDD patients (Maes et al, ; Stefanescu and Ciobica, ). Furthermore, Talarowska et al () showed a decrease in manganese superoxide dismutase gene expression and total protein in recurrent MDD patients. The serum of MDD patients also has an increase of the lipid peroxidation marker MDA (Stefanescu and Ciobica, ).The brain uses a large amount of oxygen, thus this tissue is more vulnerable to oxidative damage (Talarowska et al, ).…”

Section: Discussionmentioning

confidence: 99%

A single dose of S‐ketamine induces long‐term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation

Réus

Carlessi

Titus

et al. 2015

Developmental Neurobiology

View full text Add to dashboard Cite

Ketamine, an antagonist of N-methyl-d-aspartate receptors, has produced rapid antidepressant effects in patients with depression, as well as in animal models. However, the extent and duration of the antidepressant effect over longer periods of time has not been considered. This study evaluated the effects of single dose of ketamine on behavior and oxidative stress, which is related to depression, in the brains of adult rats subjected to maternal deprivation. Deprived and nondeprived Wistar rats were divided into four groups nondeprived+saline; nondeprived+S-ketamine (15 mg/kg); deprived+saline; deprived+S-ketamine (15 mg/kg). A single dose of ketamine or saline was administrated during the adult phase, and 14 days later depressive-like behavior was assessed. In addition, lipid damage, protein damage, and antioxidant enzyme activities were evaluated in the rat brain. Maternal deprivation induces a depressive-like behavior, as verified by an increase in immobility and anhedonic behavior. However, a single dose of ketamine was able to reverse these alterations, showing long-term antidepressant effects. The brains of maternally deprived rats had an increase in protein oxidative damage and lipid peroxidation, but administration of a single dose of ketamine reversed this damage. The activities of antioxidant enzymes superoxide dismutase and catalase were reduced in the deprived rat brains. However, ketamine was also able to reverse these changes. In conclusion, these findings indicate that a single dose of ketamine is able to induce long-term antidepressant effects and protect against neural damage caused by oxidative stress in adulthood rats following maternal deprivation.

show abstract

Section: Discussionmentioning

confidence: 99%

A single dose of S‐ketamine induces long‐term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation

Réus

Carlessi

Titus

et al. 2015

Developmental Neurobiology

View full text Add to dashboard Cite

show abstract

“…These tests were preceded by a determination of serum total protein. Two measurement techniques were employed [ 19 ]. For the quantitative detection of serum SOD2 protein levels, a commercial kit, NWLSSTM MnSOD ELISA, was used (Northwest Life Science Specialties LLC, Vancouver, Wash., USA).…”

Section: Methodsmentioning

confidence: 99%

“…For the quantitative detection of serum SOD2 protein levels, a commercial kit, NWLSSTM MnSOD ELISA, was used (Northwest Life Science Specialties LLC, Vancouver, Wash., USA). The human MnSOD and GADPH expression the peripheral blood lymphocytes was quantified by real-time PCR using ABI Prism 7000 Sequence Detection System (Applied Biosystems, Foster City, Calif., USA) according to the manufacturer’s protocol [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Oxidant/antioxidant imbalance is an inherent feature of depression

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background50% to 60% of the people who have recovered from the first episode of depression experience a relapse. The immune system of the people suffering from depression is in a permanent state of pathological pro-inflammatory readiness. There are some reports that depressive episodes cause sensitization of immune-inflammatory pathways and that staing of depression (e.g. number of depressive episodes) is correlated with immune-inflammatory markers.The main objective of the study was to delineate whether recurrent major depression (rDD) is characterized by alterations in selected immune-inflammatory biomarkers as compared with first episode of depression (ED-I), i.e. expression of mRNA and enzymatic activity of manganese superoxide dismutase (MnSOD, SOD-2), myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS, NOS-2), and cyclooxygenase-2 (COX-2).MethodsThe study was carried out in a group of 131 patients: ED-I group – 42 patients, rDD group – 89 patients. Depression severity was assessed with the 17-item Hamilton Depression Rating Scale (HDRS). The number of depression episodes and the disease duration periods were recorded in each patient. For the patients, HDRS was administered at admission during the symptomatic phase, which would generally be either before or shortly after modification of the previous antidepressant drug regimen. Reassessment of the mental condition was conducted after 8 weeks of the pharmacological treatment also with the use of the HDRS scale.ResultsNo significant statistical differences were found between the analysed groups as regards the intensity of depressive disorders. No differences in the expression of MnSOD, MPO, COX-2 and i-NOS genes on the level of both mRNA and protein were observed between both groups. No significant interrelation was noticed between the number of depression episodes experienced and the expression of selected genes on the mRNA level and protein level.ConclusionsThere is no significant difference in MnSOD, MPO, COX-2 and i-NOS between patients with recurrent depressive disorders and those in a first episode of depression. These findings suggest that these enzymes are trait markers of depression and are not related to staging of depression.

show abstract

“…To our knowledge, this is the first study to systematically investigate the roles of peripheral gene expression for indicators of inflammation and ox-idative balance in personality traits predisposing to a depressive episode. In our previous papers we referred to oxidative and antioxidative imbalances and immune system disorders in patients with symptoms of depression and among healthy people: MnSOD [24], MPO [25], COX-2 [26], iNOS [27], MMP-2 and MMP-9 [28]. At this point, we would like to summarise the correlations related to the functioning of the immune and emotional systems.…”

Section: Discussionmentioning

confidence: 99%

Immune to happiness – inflammatory process indicators and depressive personality traits

Talarowska¹,

Kowalczyk²,

Maes³

et al. 2020

aoms

Self Cite

View full text Add to dashboard Cite

Introduction: Nowadays, depression is conceptualized as an immune-inflammatory and oxidative stress disorder associated with neuroprogressive changes as a consequence of peripherally activated immune-inflammatory pathways, including peripheral cytokines and immune cells which penetrate into the brain via the blood barrier, as well as nitro-oxidative stress and antioxidant imbalances. The aim of this study was to investigate whether personality traits predisposing to a depressive episode (hypochondria, dysthymic, hysteria) are associated with changes in peripheral gene expression for selected indicators of inflammation and oxidative balance. Material and methods: One hundred four people meeting the diagnostic criteria specified for a depressive episode took part in the study. Selected scales of the Minnesota Multiphasic Personality Inventory (MMPI-2) were used to measure personality traits. Expression at the mRNA and protein level for manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and metalloproteinases 2 and 9 (MMP-2, MMP-9) was examined. Results: Scales for the neurotic triad of the MMPI-2 test correlated significantly with the expression at the level of mRNA and protein for MnSOD, MPO and metalloproteinases 2 and 9. Conclusions: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression.

show abstract

Manganese Superoxide Dismutase Gene Expression and Cognitive Functions in Recurrent Depressive Disorder

Cited by 27 publications

References 35 publications

A single dose of S‐ketamine induces long‐term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation

A single dose of S‐ketamine induces long‐term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation

Oxidant/antioxidant imbalance is an inherent feature of depression

Immune to happiness – inflammatory process indicators and depressive personality traits

Contact Info

Product

Resources

About