Gene expression profiling of human satellite cells during muscular aging using cDNA arrays

Bortoli, Sylvie; Renault, Valérie; Éveno, É.; Auffray, Charles; Butler-Browne, Gillian; Piétu, Geneviève

doi:10.1016/j.gene.2003.08.025

Cited by 48 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike HSCs and ISCs, the frequency of satellite cells decreases with age (Brack et al, 2005;Collins et al, 2007;Gibson and Schultz, 1983). The in vitro proliferation rate and the in vivo engraftment and regeneration potential of satellite cells upon transplantation also decline with age (Bernet et al, 2014;Bortoli et al, 2003;Collins et al, 2007;Cosgrove et al, 2014;Sousa-Victor et al, 2014). Furthermore, like HSCs, aged satellite cells exhibit a skewed differentiation potential, whereby they differentiate towards a fibrogenic lineage rather than a myogenic lineage, largely because of changes in Wnt and TGF-β signaling (Brack et al, 2007;Carlson et al, 2009).…”

Section: Satellite Cellsmentioning

confidence: 99%

When stem cells grow old: phenotypes and mechanisms of stem cell aging

2016

View full text Add to dashboard Cite

All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and germline. Here, we discuss recent advances in our understanding of why adult stem cells age and how this aging impacts diseases and lifespan. With this increased understanding, it is feasible to design and test interventions that delay stem cell aging and improve both health and lifespan.

show abstract

Section: Satellite Cellsmentioning

confidence: 99%

When stem cells grow old: phenotypes and mechanisms of stem cell aging

2016

View full text Add to dashboard Cite

show abstract

“…Indeed, induced activation of Notch enhances the effective repair of aged muscle [47], while Notch inhibitors can impair the normally robust regenerative capacity of young mouse skeletal muscle. Finally, erosion of telomeric sequences owing to either repeated satellite cell recruitment, regenerative myogenesis or oxidative damage may contribute to the reduced proliferative potential of aged satellite cells and their progeny [26,54,60,61].…”

Section: Intrinsic Effects On Repair Activity In Aged Skeletal Musclementioning

confidence: 99%

Stem cells for skeletal muscle repair

Shadrach

Wagers

2011

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle precursor cells, which generate both differentiated muscle fibres and specialized muscle-forming stem cells known as satellite cells. Satellite cells remain associated with muscle fibres after birth and are responsible for muscle growth and repair throughout life. Failure in satellite cell function can lead to delayed, impaired or failed recovery after muscle injury, and such failures become increasingly prominent in cases of progressive muscle disease and in old age. Recent progress in the isolation of muscle satellite cells and elucidation of the cellular and molecular mediators controlling their activity indicate that these cells represent promising therapeutic targets. Such satellite cell-based therapies may involve either direct cell replacement or development of drugs that enhance endogenous muscle repair mechanisms. Here, we discuss recent breakthroughs in understanding both the cell intrinsic and extrinsic regulators that determine the formation and function of muscle satellite cells, as well as promising paths forward to realizing their full therapeutic potential.

show abstract

“…Gene expression studies from isolated satellite cells or their progeny have demonstrated that the transcriptional profile changes with age [49]. It is not known which of these alterations are due to irreversible genetic change or reversible epigenetic effects.…”

Section: Molecular and Biochemical Propertiesmentioning

confidence: 99%

Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging

2007

View full text Add to dashboard Cite

The myogenic stem cell (satellite cell) is almost solely responsible for the remarkable regeneration of adult skeletal muscle fibers after injury. The availability and the functionality of satellite cells are the determinants of efficient muscle regeneration. During aging, the efficiency of muscle regeneration declines, suggesting that the functionality of satellite cells and their progeny may be altered. Satellite cells do not sit in isolation but rather are surrounded by, and influenced by, many extrinsic factors within the muscle tissue that can alter their functionality. These factors likely change during aging and impart both reversible and irreversible changes to the satellite cells and on their proliferating progeny. In this review, we discuss the possible mechanisms of impaired muscle regeneration with respect to the biology of satellite cells. Future studies that enhance our understanding of the interactions between stem cells and the environment in which they reside will offer promise for therapeutic applications in age-related diseases.

show abstract

Gene expression profiling of human satellite cells during muscular aging using cDNA arrays

Cited by 48 publications

References 32 publications

When stem cells grow old: phenotypes and mechanisms of stem cell aging

When stem cells grow old: phenotypes and mechanisms of stem cell aging

Stem cells for skeletal muscle repair

Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging

Contact Info

Product

Resources

About