1993
DOI: 10.1002/1097-0142(19931201)72:11<3282::aid-cncr2820721125>3.0.co;2-n
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Gene expression of insulin-like growth factor II in human intracranial meningioma

Abstract: Background. Insulin‐like growth factor II (IGF‐II) is synthesized in the normal brain of adult humans predominantly in the choroid plexus and meninges and is secreted in the cerebrospinal fluid. The authors measured IGF‐II transcripts and peptides in biopsy specimens from human intracranial tumors including astrocytomas, glioblastomas, and meningiomas. Methods. The presence of IGF‐II mRNA was analyzed in 12 human brain tumors by Northern analysis of total RNA extracted from tumor biopsies and by in situ hybrid… Show more

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Cited by 22 publications
(9 citation statements)
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“…In mouse models, OE of IGF2 can lead to the development of lung tumors (18,19), loss of IGF2 imprinting promotes development of intestinal tumors (20), and IGF2 has been shown to play an essential role in the induction of medulloblastomas (21). Although previous findings reported loss of imprinting and OE of IGF2 in human meningiomas (22,23), reports on IGF2 expression in glioma have not yielded a consistent picture (24,25).…”
Section: Discussionmentioning
confidence: 98%
“…In mouse models, OE of IGF2 can lead to the development of lung tumors (18,19), loss of IGF2 imprinting promotes development of intestinal tumors (20), and IGF2 has been shown to play an essential role in the induction of medulloblastomas (21). Although previous findings reported loss of imprinting and OE of IGF2 in human meningiomas (22,23), reports on IGF2 expression in glioma have not yielded a consistent picture (24,25).…”
Section: Discussionmentioning
confidence: 98%
“…11 IGF-II mRNA was found in higher amounts in benign meningiomas than in malignant glioblastomas and astrocytomas, whereas the content of immunoreactive IGF-II peptide was comparable. 12 IGF-II mRNA expression appears to parallel the growth rate in the LI human glioblastoma cell line. 13 Upregulation of IGF-II expression is a feature of TrkA but not TrkB activation in SH-SY5Y neuroblastoma cells, suggesting that IGF-II is a component of the eVector mechanism of TrkA activation.…”
Section: Igfsmentioning
confidence: 96%
“…There is ample evidence that the levels of IGF-II mRNA differ from the protein. While IGF-II transcripts were higher than in normal tissue in prostate cancer (Tennant et al, 1996), Wilms tumors (Haselbacher et al, 1987), and glioblastomas and astrocytomas (Hultberg et al, 1993), it was not the case for the protein. High levels of IGF-II protein, but not mRNA were found in pheocromocytomas (Haselbacher et al, 1987).…”
Section: Tissue Expression Of Igfs As Risk or Prognosis Biomarkers Inmentioning
confidence: 84%