Gene delivery to dendritic cells facilitated by a tumor necrosis factor alpha-competing peptide

Chamarthy, Sai Prasanth; Long, Jia; Kovacs, Jeffrey R.; Anderson, Karl R; Shen, Hongmei; Firestine, Steven M.; Meng, Wilson S.

doi:10.1016/j.molimm.2004.04.022

Cited by 28 publications

(19 citation statements)

References 44 publications

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“…synthesized a polymeric gene vector with peptide conjugation, which significantly promoted the transfection of reporter gene coding plasmid into primary DCs. [ 87 ] After that, polymeric nonviral vectors and lipid complexes with tumor‐related gene vaccine loading become popular designs in cancer immunotherapy. As a typical example in 2016, RNA‐based liposome complexes were constructed by BioNTech company.…”

Section: Targeted and Tumor Environment Responsive Gene Delivery Intomentioning

confidence: 99%

Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy

Cai

et al. 2020

Advanced Therapeutics

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Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy. Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic genes or gene vaccines (in terms of deoxyribonucleic acid DNA or ribonucleic acid RNA) into tumor‐associated immunocytes (i.e., macrophages, T cells, or dendritic cells) in an effective and controllable manner for enhanced cancer immunotherapy. However, a timely and systematic summary of this subject is lacking. This review presents an overview of polymeric nonviral carriers with immune cell transfection ability and their potential applications in cancer immunotherapy; it also provides a tutorial for designing polymeric immune‐cell genetic modification vector, although there are still few vectors in the product pipeline. With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy.

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Section: Targeted and Tumor Environment Responsive Gene Delivery Intomentioning

confidence: 99%

Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy

Cai

et al. 2020

Advanced Therapeutics

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“…391 A TNF-α-competing (TNF-α = tumor necrosis factor-α) peptide, CYTYQGKLC, was isolated by in vitro panning against the murine dendritic cell line JAWSII, using TNF-α to elute bound phage. 392 The peptide was shown to specifically deliver genes to dendritic cells (details later). In an unbiased selection, McGuire et al also identified a novel dendritic-cell-targeting peptide, XS52.1, by in vitro panning on the mouse dendritic cell line XS52, derived from mouse skin.…”

Section: Isolation Of Disease-specific or Organ-specific Peptidesmentioning

confidence: 99%

Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides

2013

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“…The MS have an average diameter of 0.1 micron (mm) with less than 10% variance. We have worked with these MS in a previous study aimed at delivering plasmid DNA to DC via the tumor necrosis factor receptor system [17]. The delivery system in the current study was formulated as follow: 3 ml of the MS (2.5% w/v; 4.55 Â 10 13 particles ml À1 ) were first coated with 200 mg of O 10 H 6 (gentle shaking for 2 h at RT) in 300 ml of ddH 2 O.…”

Section: Preparation Of Microsphere Dna Complexesmentioning

confidence: 99%