Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives

Studies of the physicochemical and structural properties of self-assembling cationic pyridine derivatives as gene delivery agents

“…1), which were capable of transfecting plasmid DNA (pDNA) into different cell lines in vitro (Hyvonen et al, 2000;Pajuste et al, 2013).…”

Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles

“…1,4 Preparation of magnetic nanoparticles. Magnetic maghemite (γ-Fe 2 O 3 ) NPs were synthesized according to the method described in literature.…”

“…1), since this compound possesses a significant gene delivery capacity. 1,4 Its packing parameter is of the order of 0.4-0.8 which explains its propensity for self-assembling in bilayers and liposomes. 20 the sonication method in aqueous media from amphiphile 1 and its close structural analogs with various ester groups at positions 3 and 5 of the 1,4-DHP ring and in the 75-350 nm range if obtained from close structural analogs with various cationic headgroups at positions 2 and 6 of the 1,4-DHP ring.…”

“…Additionally, these self-assembling compounds possess antiradical activity. 4 During the last few years, the antioxidant and antiradical activities of different nanoparticles and nanoparticle-formed compounds have been very attractive and perspective research areas. [5][6][7] Indeed, the positively charged surface of these cationic liposomes easily interacts with the negatively charged cell surface and makes them efficient carriers for transport of different chemical compounds into cells.…”

“…20 the sonication method in aqueous media from amphiphile 1 and its close structural analogs with various ester groups at positions 3 and 5 of the 1,4-DHP ring and in the 75-350 nm range if obtained from close structural analogs with various cationic headgroups at positions 2 and 6 of the 1,4-DHP ring. 4 In order to produce magnetoliposomes using the sonication method, the mixture of compound 1 and magnetic fluid in water was sonicated for 40-60 min depending on the ferrofluid used (FF ac or FF citr ). The liposome dispersions in both cases were investigated by transmission electron microscopy (TEM), and the results are presented in Figure 2.…”