Gene chip technology used in the detection of HPV infection in esophageal cancer of Kazakh Chinese in Xinjiang Province

Chen, Weigang; Yang, Chunmei; Xu, Li‐Hong; Zhang, Ning; Liu, Xiaoyan; Ma, Yungui; Huo, Xiao-Ling; Han, Yusheng; Tian, Dean; Zheng, Yong

doi:10.1007/s11596-014-1280-6

Cited by 11 publications

(9 citation statements)

References 14 publications

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“…Currently, studies show a higher prevalence of HPV infection in patients with ESCC in Asia, compared to Europe and America (Ludmir, Stephens, Palta, Willett, & Czito, ). A study by Chen et al examined the ESCC samples of Kazakh from Xinjiang (China); HPV DNA was found in 66.67% of ESCCs (Chen, Yang, et al, ). Similarly, Dong and coworkers from China recently showed that HPV was present in 51.7% of the 89 ESCC samples (Dong et al, ).…”

Section: Esophageal Cancermentioning

confidence: 99%

Role of viruses in gastrointestinal cancer

Mirzaei¹,

Goudarzi²,

Eslami³

et al. 2017

Journal Cellular Physiology

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Gastrointestinal cancers are a global public health problem, which represent a vast majority of all cancer‐caused deaths in both men and women. On the other hand, viral pathogens have been long implicated as etiological factors in the onset of certain human cancers, including gastrointestinal tumors. In this regard, Human Papilloma Virus (HPV), Epstein‐Barr Virus (EBV), and John Cunningham Virus (JCV) have been more strongly suggested to be involved in gastrointestinal carcinogenesis; so that, the association of HPV with oropharyngeal and anal cancers and also the association of EBV with gastric cancer have been etiologically confirmed by epidemiological and experimental investigations. Although, the association of other viruses is less evident, but may rely on co‐factors for their oncogenic roles. Therefore, to improve the prevention and treatment of these classes of cancer, their association with viral agents as potential risk factors should be investigated with care. In this respect, the present review has focused on the existing literature on the subject of viral involvement in gastrointestinal tumorgenesis, by covering and discussing various gastrointestinal cancers, corresponding viral agents and their oncogenic aspects and then summarizing evidences either supporting or rejecting a causal role of these pathogens in gastrointestinal malignancies.

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Section: Esophageal Cancermentioning

confidence: 99%

Role of viruses in gastrointestinal cancer

Mirzaei¹,

Goudarzi²,

Eslami³

et al. 2017

Journal Cellular Physiology

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“…In recent years, contrast-enhanced ultrasound, fluorodeoxyglucose-positron emission, tomography (FDG-PET), CECT and chip technology have been widely used in the diagnosis of human cancer ( 27 , 28 ). In particular, CECT and chip technology present more advantages than other diagnostic methods ( 29 , 30 ). However, the application of gene chip technology is restricted due to expensive detection and the professional analysts required ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Zhang

et al. 2017

Exp Ther Med

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Gastric cancer is one of the most common human tumors worldwide. The biggest bottleneck is a lack of advanced and sensitive protocols for the diagnosis of patients with early-stage gastric cancer. Therefore, more sensitive methods of diagnosing gastric cancer are urgently required to improve survival rates. In this clinical study, contrast-enhanced computed tomography (CECT) with targeting nanoparticles contrast agent (CECT-TNCA) was used to diagnose early-stage gastric cancer. The specific-targeted tyrosine kinase inhibitors of gastric cancer, including platelet-derived growth factor receptor-β, Ret and Kit, were used as TNCAs. A total of 484 patients with suspected gastric cancer were voluntarily recruited to investigate the efficacy of CECT-TNCA in the diagnosis of patients with early-stage gastric cancer. Patients with suspected gastric cancer were subjected CT and CECT-TNCA to detect whether gastric tumors existed. TNCA was orally administered before CT and CECT-TNCA (20 min). Our diagnostic data revealed that CECT-TNCA improved sensitivity and provided a new protocol to diagnose tumors in patients with suspected gastric cancer at the early stage. In addition, imaging using CECT-TNCA enabled the visualization of tiny nodules in the gastric area. CECT-TNCA diagnosed 182 patients with suspected gastric cancer as tumor-free. CECT-TNCA confirmed gastric cancer in 302 patients. Our novel diagnosis indicated significantly (P<0.01) differential signal enhancement in the gastric nodules via CECT-TNCA compared with CT, suggesting higher accuracy and the accumulation of TNCA in tumor nodules in the stomach. Furthermore, survival rates of patients detected by early-diagnosis of CECT-TNCA were significantly higher than the mean five-year survival (P<0.01). In conclusion, our investigations demonstrate that the sensibility and accuracy of CT is improved through combination with liposome-encapsulated nanoparticle contrast agent for the diagnosis of early stage gastric cancer when compared with single CT detection. CECT-TNCA improves the accuracy of CT and diagnostic confidence in assessing mural enhancement in patients with suspected gastric cancer.

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“…Other methods involved in studies of HPV and ESCC include ISH and enzyme-linked immunosorbent assay (ELISA) [27,31] . However, techniques based on high-throughput analysis are developing rapidly; gene chips and genome-wide association studies are also used in research [32,33] . Moreover, metaanalysis, a type of data analysis based on the results of previous studies, has been used to investigate the prevalence of HPV in ESCC [34][35][36] .…”

Section: Detection Of Hpv In Ecmentioning

confidence: 99%

“…Studies from highrisk regions in China (Anyang, Xinjiang, Sichuan) indicated that there was strong evidence of an association between HPV and ESCC [31,32,37] . He et al [31] tested samples from 1,435 patients with ESCC from Anyang (China); the serological results demonstrated that the presence of HPV16 E7 was associated with an increased risk of ESCC.…”

Section: Evidence Of a Positive Association Between Hpv And Esccmentioning

confidence: 99%

“…He et al [31] tested samples from 1,435 patients with ESCC from Anyang (China); the serological results demonstrated that the presence of HPV16 E7 was associated with an increased risk of ESCC. Chen et al [32] screened HPV types associated with ESCC of Kazakh from Xinjiang (China) by gene chip; their results showed that the rate of infection with HPV was 66.67% in the ESCC group, while that of HPV16 was 97.72% and the rate of co-infection with HPV16 and HPV18 was 2.27%. A hospitalbased case-control study of 99 patients with ESCC and 100 healthy controls in an Australian cohort suggested that HPV may be an additional risk factor in the multifactorial etiology of EC, although a larger, better-powered study is needed [29] .…”

Section: Evidence Of a Positive Association Between Hpv And Esccmentioning

confidence: 99%

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Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

Liu

Bao

et al. 2015

Gastrointest Tumors

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Background: Esophageal cancer (EC) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. Despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. The etiology of EC remains poorly understood; multiple risk factors may be involved and account for the great variation in EC incidence in different geographic regions. Summary: Infection with carcinogenetic pathogens has been proposed as a risk factor for EC. This review explores the recent studies on the association of human papillomavirus (HPV), Epstein-Barr virus (EBV), Helicobacter pylori and esophageal bacterial biota with EC. Key Message: Among the above-mentioned pathogens, HPV most likely contributes to esophageal squamous cell carcinoma (ESCC) in high-risk populations. New techniques are being applied to studies on the role of infection in EC, which will inevitably bring novel ideas to the field in the near future. Practical Implications: Multiple meta-analyses support the finding of a higher HPV detection rate in regions associated with high risk for ESCC compared to low-risk areas. A potential role of HPV in the rise of esophageal adenocarcinoma (EAC) was proposed recently. However, further studies are required before a firm conclusion can be drawn. Less work has been done in studying the association between EBV and ESCC, and the results are quite controversial. H. pylori infection is found to be inversely related to EC, which is probably due to the reduced incidence of gastroesophageal reflux disease. Analysis of the esophageal bacterial biota revealed distinct clusters of bacteria in normal and diseased esophagi. A type II microbiome rich in Gram-negative bacteria potentially contributes to EAC by inducing chronic inflammation. Novel findings from such studies as these may benefit public health by justifying anti-infection measures to prevent EC.

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Gene chip technology used in the detection of HPV infection in esophageal cancer of Kazakh Chinese in Xinjiang Province

Cited by 11 publications

References 14 publications

Role of viruses in gastrointestinal cancer

Role of viruses in gastrointestinal cancer

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

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