Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES

Abstract

BackgroundThe relationship between oxidative balance score (OBS) and diabetes remains poorly understood and may be gender-specific. We conducted a cross-sectional study to investigate the complex association between OBS and diabetes among US adults.MethodsOverall, 5,233 participants were included in this cross-sectional study. The exposure variable was OBS, composed of scores for 20 dietary and lifestyle factors. Multivariable logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were applied to examine the relationship between OBS and diabetes.ResultsCompared to the lowest OBS quartile group (Q1), the multivariable-adjusted odds ratio (OR) (95% confidence interval (CI) for the highest OBS quartile group (Q4) was 0.602 (0.372–0.974) (p for trend = 0.007), and for the highest lifestyle, the OBS quartile group was 0.386 (0.223–0.667) (p for trend < 0.001). Moreover, gender effects were found between OBS and diabetes (p for interaction = 0.044). RCS showed an inverted-U relationship between OBS and diabetes in women (p for non-linear = 6e−04) and a linear relationship between OBS and diabetes in men.ConclusionsIn summary, high OBS was negatively associated with diabetes risk in a gender-dependent manner.

Association between oxidative balance score and metabolic syndrome and its components in US adults: a cross-sectional study from NHANES 2011–2018

“…This study found that higher OBS values were associated with a decreased risk of elevated FBG ( 24 ). Oxidative stress is involved in the onset and progression of diabetes and IR ( 14 ).…”

“…Based on previous studies, lower scores across all OBSs indicate higher oxidative stress, which is associated with adverse clinical outcomes ( 21 ). The relationships between OBS and hypertension ( 23 ), diabetes ( 24 ), nonalcoholic fatty liver disease ( 25 ), cancer ( 26 ), all-cause mortality ( 27 ) and biological aging ( 28 ) have been intensively investigated and widely discussed. However, relatively few studies probe the correlation between attitudes toward OBS and MetS risk.…”

The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

“…Based on previous research and experience, 23–25 the OBS calculation method combined 16 dietary components and 4 lifestyle components. The lifestyle components are physical activity, body mass index (BMI), alcohol consumption, and cotinine.…”

Association between oxidative balance score and self-reported severe headache or migraine based on NHANES 1999 to 2004 data: A cross-sectional study

“…The Oxidative Balance Score (OBS) is a comprehensive metric assessing the balance between pro-oxidants and antioxidants in an individual's diet and lifestyle [ 7 , 14 ]. Generally, a higher OBS indicates a dominance of antioxidants over pro-oxidants.…”