Gender-related differences in the progression of carotid stiffness with age and in the influence of risk factors on carotid stiffness

Łoboz-Rudnicka, Maria; Jaroch, Joanna; Kruszyńska, Ewa; Bociąga, Zbigniew; Rzyczkowska, Barbara; Dudek, Krzysztof; Szuba, Andrzej; Łoboz‐Grudzień, Krystyna

doi:10.2147/cia.s161711

Cited by 21 publications

(19 citation statements)

References 30 publications

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“…This confined to women relationship between PP and CS was described previously in a population of subjects with cardiovascular risk factors. 26 We did not find a significant difference in PP values in women and men, either in the whole study group or in patients with MS. However, women with MS presented with significantly higher PP than healthy controls, whereas no between-group differences in PP were found among men.…”

Section: Relationship Between Cardiovascular Risk Factors and Carotidcontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

“…36,37 The age-dependent rise in CS measured by eT may show different patterns: with linear increase for PWV-beta and curvilinear (with steeper progress in middle and older age) for beta and Ep. 22,26 Another potent determinant of arterial stiffness, also in patients with MS, is arterial blood pressure. While the relationship between elevated blood pressure and arterial stiffness has been well documented, the question whether an increase in arterial stiffness predisposes to higher blood pressure or vice versa is still a matter of a debate.…”

Section: Relationship Between Cardiovascular Risk Factors and Carotidmentioning

confidence: 99%

“…However, only few previous studies analyzed local stiffness determined with the eT method in the context of patient's sex. 26 In some of those studies, the relationship between the number of MS components present in a given patient and the arterial stiffness turned out to be stronger in women than in men. 27 We hypothesized that functional changes in carotid arteries of women and men with MS are determined by different factors.…”

Section: Introductionmentioning

confidence: 99%

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<p>Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences</p>

Kruszyńska¹,

Łoboz-Rudnicka²,

Palombo

et al. 2020

DMSO

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Introduction: The effect of metabolic syndrome (MS) on carotid stiffness (CS) in the context of gender is under research. Objective: We examined the relationship between the MS and CS in men (M) and women (W) and investigated if the impact of cardiovascular risk factors on CS is modulated by gender. Patients and Methods: The study included 419 subjects (mean age 54.3 years): 215 (51%) with MS (109 W and 106 M) and 204 (49%) without MS (98 W and 106 M). Carotid intimamedia thickness (IMT) and CS parameters (beta stiffness index (beta), Peterson's elastic modulus (Ep), arterial compliance (AC) and one-point pulse wave velocity (PWV-beta)) were measured with the echo-tracking (eT) system. Results: ANCOVA demonstrated that MS was associated with elevated CS indices (p = 0.003 for beta and 0.025 for PWV-beta), although further sex-specific analysis revealed that this relationship was significant only in W (p = 0.021 for beta). Age was associated with CS in both M and W, pulse pressure (PP) and body mass index turned out to be determinants of CS solely in W, while the effect of mean arterial pressure (MAP) and heart rate was more pronounced in M. MANOVA performed in subjects with MS revealed that age and diabetes mellitus type 2 were determinants of CS in both sexes, diastolic blood pressure and MAPsolely in M and systolic blood pressure, PP and waist circumference-solely in W (the relationship between the waist circumference and AC was paradoxical). Conclusion: The relationship between MS and CS is stronger in W than in M. In subjects with MS, various components of arterial pressure exert different sex-specific effects on CSwith the impact of the pulsative component of arterial pressure (PP) observed in W and the impact of the steady component (MAP) observed in M.

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Section: Relationship Between Cardiovascular Risk Factors and Carotidcontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Relationship Between Cardiovascular Risk Factors and Carotidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences</p>

Kruszyńska¹,

Łoboz-Rudnicka²,

Palombo

et al. 2020

DMSO

Self Cite

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“…Carotid movement (M)- and brightness (B)-mode ultrasound scans of the right and left common arteries were performed with a Sonix Touch Instrument with a 7.5 MHz transducer (Analogic Corporation, Peabody, MD, USA). All scan and image analyses have been described previously [ 27 , 28 ]. In short, M-mode ultrasound scans depicted near and far wall movements of the distal common carotid artery for at least three consecutive heartbeats.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals

et al. 2020

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Cognitive decline is associated with lifestyle-related factors such as overweight, blood pressure, and dietary composition. Studies have reported beneficial effects of dietary anthocyanins on cognition in older adults and children. However, the effect of anthocyanin-rich Aronia melanocarpa extract (AME) on cognition is unknown. Therefore, this study aimed to determine the effect of long-term supplementation with AME on cognitive performance, mood, and vascular function in healthy, middle-aged, overweight adults. In a randomized double-blind placebo-controlled parallel study, 101 participants either consumed 90 mg AME, 150 mg AME, or placebo for 24 weeks. The grooved pegboard test, number cross-out test, and Stroop test were performed as measures for psychomotor speed, attention, and cognitive flexibility. Mood was evaluated with a visual analogue scale, serum brain-derived neurotrophic factor (BDNF) was determined, and vascular function was assessed by carotid ultrasounds and blood pressure measurements. AME improved psychomotor speed compared to placebo (90 mg AME: change = −3.37; p = 0.009). Furthermore, 150 mg AME decreased brachial diastolic blood pressure compared to 90 mg AME (change = 2.44; p = 0.011), but not compared to placebo. Attention, cognitive flexibility, BDNF, and other vascular parameters were not affected. In conclusion, AME supplementation showed an indication of beneficial effects on cognitive performance and blood pressure in individuals at risk of cognitive decline.

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Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study

Aimagambetova,

Ariko,

Gardener

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONArterial stiffness is linked to age‐related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population.METHODSWe included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI‐cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non‐Hispanic Black, 15% non‐Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5.0 ± 0.6 years later. ePWV was calculated using baseline age and blood pressure. Cognition and cognitive change scores were regressed on ePWV in multivariable linear regression models.RESULTSIn adjusted models, ePWV (mean 11 ± 2 m/s) was significantly associated with cognition (b = −0.100, 95% CI, −0.120, −0.080) and cognitive change over time (b = −0.063, 95% CI, −0.082, −0.045). Effect modification by race and sex was found.DISCUSSIONIn this multiethnic population, the associations of ePWV with cognitive performance underline the role of vascular stiffness in age‐related cognitive decline.Highlights ePWV is a modest but independent predictor of cognitive function and cognitive decline among older individuals. After adjustment, the ePWV measure was inversely associated with performance and decline in global cognition, processing speed, episodic memory, executive function, and semantic memory. After adjustment, modification of the association between ePWV and change in episodic memory and executive function by race and ethnicity was suggested by a significant interaction term. The association between ePWV and episodic memory decline was stronger in females.

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Gender-related differences in the progression of carotid stiffness with age and in the influence of risk factors on carotid stiffness

Cited by 21 publications

References 30 publications

<p>Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences</p>

<p>Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences</p>

The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals

Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study

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