Gender influences outcomes in trauma patients with elevated systolic blood pressure

Clond, Morgan A.; Mirocha, James; Singer, Matthew M.; Bukur, Marko; Salim, Ali; Marguiles, Daniel R.; Ley, Eric J.

doi:10.1016/j.amjsurg.2011.06.044

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…The effect of gender on trauma survival in people is controversial, with most studies suggesting either a survival advantage for women or no effect. [1][2][3][4][5][6][7][8][9] Few studies indicate a survival advantage for men. 10 While poorly understood, explanations for any gender difference in human trauma survival are generally based on hormone-driven differences in physiological response.…”

Section: Introductionmentioning

confidence: 99%

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The effects of sex and neuter status on trauma survival in dogs: A Veterinary Committee on Trauma registry study

Fontes

McCarthy

Kutzler

et al. 2022

J Vet Emergen Crit Care

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Section: Introductionmentioning

confidence: 99%

“…The effect of gender on trauma survival in people is controversial, with most studies suggesting either a survival advantage for women or no effect 1–9 . Few studies indicate a survival advantage for men 10 .…”

Section: Introductionmentioning

confidence: 99%

The effects of sex and neuter status on trauma survival in dogs: A Veterinary Committee on Trauma registry study

Fontes

McCarthy

Kutzler

et al. 2022

J Vet Emergen Crit Care

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“…Seven studies (59,62,69,75,87,92,99) examined differences between the sexes in covariates of the outcomes by stratifying their cohorts according to sex (Table 3). When observing the studied variables' effects on the outcomes of interest within the two sex groups, it is apparent that some variables exhibited less variation in the strength of their associations with certain outcomes.…”

Section: Studies Disaggregating Data By Sex/gendermentioning

confidence: 99%

“…When observing the studied variables' effects on the outcomes of interest within the two sex groups, it is apparent that some variables exhibited less variation in the strength of their associations with certain outcomes. For example, many studied variables were associated with discrete outcomes, such as mortality, dementia, pneumonia, non-affective psychosis, and hospital readmission, in both sexes with moderate-to-severe TBI (62,75,87,99). Other variables, such as insomnia severity, post-traumatic stress disorder, and age, were connected to the outcome in male or female persons only, (59,69,92) although these variations emerged in persons with mild TBI only.…”

Section: Studies Disaggregating Data By Sex/gendermentioning

confidence: 99%

Systematic Review of Sex and Gender Effects in Traumatic Brain Injury: Equity in Clinical and Functional Outcomes

Mollayeva

Pacheco

et al. 2021

Front. Neurol.

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Background: Although traumatic brain injury (TBI) is a leading cause of death and disability in male and female patients worldwide, little is known about the effect of sex and gender on TBI outcomes.Objectives: This systematic review summarizes the evidence on the effect of sex and gender on core TBI outcomes.Methods: All English-language studies from six literature databases that addressed core outcomes in adults with TBI and included sex or gender, TBI severity, and age in their analyses were considered eligible. Two reviewers extracted data, and two reviewers assessed study quality using tools recommended by the National Institutes of Health. The results were sorted according to time post-injury, injury severity, gender equity ranking of the study's country of origin, and outcomes studied. The results from the included studies were grouped based on the approach taken in reporting their respective findings.Results and Limitations: Of 172 articles assessed, 58 studies were selected, comprising 1, 265, 955 participants with TBI (67% male across all studies) of all injury severities. All studies were conducted in countries with a very high or high human development index, while the Gender Inequality Index (GII) varied. While the heterogeneity across studies limited any meaningful conclusions with respect to the role of sex and gender, we did observe that as gender equality ranking improved, differences between male and female participants in outcomes would diminish. Inclusion of social equity parameters in the studies was limited.Conclusions and Implications: The non-uniform findings observed bring forth the need to develop and use a comprehensive and consistent methodology in the study of sex and gender post-TBI, incorporating social equity parameters to uncover the potential social underpinnings of gender effects on health and functional outcomes.Systematic Review Registration: CRD42018098697.

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“…Recent data in trauma patients suggest that hypotension as well as hypertension can predict mortality in trauma patients. [ 3 4 5 ] Zafar et al . [ 6 ] have demonstrated that both hypertensive and hypotensive traumatic brain injured patients have increased mortality.…”

Section: Introductionmentioning

confidence: 99%

Extremes of shock index predicts death in trauma patients

Odom

Howell

Gupta

et al. 2016

J Emerg Trauma Shock

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Context:We noted a bimodal relationship between mortality and shock index (SI), the ratio of heart rate to systolic blood pressure.Aims:To determine if extremes of SI can predict mortality in trauma patients.Settings and Designs:Retrospective evaluation of adult trauma patients at a tertiary care center from 2000 to 2012 in the United States.Materials and Methods:We examined the SI in trauma patients and determined the adjusted mortality for patients with and without head injuries.Statistical Analysis Used:Descriptive statistics and multivariable logistic regression. Results: SI values demonstrated a U-shaped relationship with mortality. Compared with patients with a SI between 0.5 and 0.7, patients with a SI of <0.3 had an odds ratio for death of 2.2 (95% confidence interval [CI] 21.2–4.1) after adjustment for age, Glasgow Coma score, and injury severity score while patients with SI >1.3 had an odds ratio of death of 3.1. (95% CI 1.6–5.9). Elevated SI is associated with increased mortality in patients with isolated torso injuries, and is associated with death at both low and high values in patients with head injury.Conclusion:Our data indicate a bimodal relationship between SI and mortality in head injured patients that persists after correction for various co-factors. The distribution of mortality is different between head injured patients and patients without head injuries. Elevated SI predicts death in all trauma patients, but low SI values only predict death in head injured patients.

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Gender influences outcomes in trauma patients with elevated systolic blood pressure

Cited by 7 publications

References 37 publications

The effects of sex and neuter status on trauma survival in dogs: A Veterinary Committee on Trauma registry study

The effects of sex and neuter status on trauma survival in dogs: A Veterinary Committee on Trauma registry study

Systematic Review of Sex and Gender Effects in Traumatic Brain Injury: Equity in Clinical and Functional Outcomes

Extremes of shock index predicts death in trauma patients

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