Gender gap in annual preventive care services in France

Gaye, Bamba; Hergault, Hélène; Lassale, Camille; Ladouceur, Magalie; Valentin, Eugenie; Vignac, Maxime; Danchin, Nicolás; Diaw, Mor; Kvaskoff, Marina; Chamieh, Sarah; Thomas, Frédérique; Michos, Erin D.; Jouven, Xavier

doi:10.1016/j.eclinm.2022.101469

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…3,5 People who are attending preventive medical centers are more health conscious and are in better health than the general population of same age and sex. 35 This may affect the distribution of cTnI and risk factors in general (ie towards lower values) but not the association between cTnI and CVD events. Finally, the findings on cTnI were obtained from an assay that is currently for research purposes only.…”

Section: Discussionmentioning

confidence: 99%

Ultrasensitive Troponin I and Incident Cardiovascular Disease

Empana

Lerner

Perier

et al. 2022

ATVB

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Background: To examine the association of ultrasensitive cTnI (cardiac troponin I) with incident cardiovascular disease events (CVDs) in the primary prevention setting. Methods: cTnI was analyzed in the baseline plasma (2008–2012) of CVD-free volunteers from the Paris Prospective Study III using a novel ultrasensitive immunoassay (Simoa Troponin-I 2.0 Kit, Quanterix, Lexington) with a limit of detection of 0.013 pg/mL. Incident CVD hospitalizations (coronary heart disease, stroke, cardiac arrhythmias, deep venous thrombosis or pulmonary embolism, heart failure, or arterial aneurysm) were validated by critical review of the hospital records. Hazard ratios were estimated per log-transformed SD increase of cTnI in Cox models using age as the time scale. Results: The study population includes 9503 participants (40% women) aged 59.6 (6.3) years. cTnI was detected in 99.6% of the participants (median value=0.63 pg/mL, interquartile range, 0.39–1.09). After a median follow-up of 8.34 years (interquartile range, 8.0–10.07), 516 participants suffered 612 events. In fully adjusted analysis, higher cTnI (per 1 SD increase of log cTnI) was significantly associated with CVD events combined (hazard ratio, 1.18 [1.08–1.30]). Among all single risk factors, cTnI had the highest discrimination capacity for incident CVD events (C index=0.6349). Adding log cTnI to the SCORE 2 risk improved moderately discriminatory capacity (C index 0.698 versus 0.685; bootstrapped C index difference: 0.0135 [95% CI, 0.0131–0.0138]), and reclassification of the participants (categorical net reclassification index, 0.0628 [95% CI, 0.023–0.102]). Findings were consistent using the US pooled cohort risk equation. Conclusions: Ultrasensitive cTnI is an independent marker of CVD events in the primary prevention setting.

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Section: Discussionmentioning

confidence: 99%

Ultrasensitive Troponin I and Incident Cardiovascular Disease

Empana

Lerner

Perier

et al. 2022

ATVB

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“…In order to tackle the growing burden of CVD in Africa, it is important to consider the unique dynamics of Africa's CVD epidemic. Identifying environmental exposures and novel disease mechanisms, such epigenetic modifiers, can help discover a set of therapeutic targets useful for directed screening and ultimately achieving better treatment for every individual [5]. In addition, robust health systems equipped with the essential logistics to provide CVD care across all spectrums of disease should be built or enhanced.…”

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confidence: 99%

Advancing the Cardiovascular Workforce in Africa to Tackle the Epidemic of Cardiovascular Disease: The Time is Now

Ahadzi¹,

Gaye²,

Commodore‐Mensah

2023

Global Heart

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The African region is experiencing an epidemic of cardiovascular disease with dire consequences of increasing morbidity and mortality. Compared with highincome countries where older populations are most affected, the burden of CVD in Africa is higher in the younger populations, which hampers regional socioeconomic development. Strategies to increase and advance the cardiovascular workforce are urgently needed to help address this problem. This commentary highlights the critical lack of skilled cardiovascular healthcare professionals, including cardiologists, cardiac surgeons, and cardiovascular nurses in the African region. Multilevel viable solutions to advance the cardiovascular workforce in Africa based on successful models in Africa are also presented.

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Gender gap in annual preventive care services in France

Cited by 2 publications

References 39 publications

Ultrasensitive Troponin I and Incident Cardiovascular Disease

Ultrasensitive Troponin I and Incident Cardiovascular Disease

Advancing the Cardiovascular Workforce in Africa to Tackle the Epidemic of Cardiovascular Disease: The Time is Now

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