Gender Equivalence in the Prevalence of Nephrolithiasis among Adults Younger than 50 Years in the United States

Tundo, Gina; Khaleel, Sari; Pais, Vernon M.

doi:10.1016/j.juro.2018.07.048

Cited by 28 publications

(15 citation statements)

References 15 publications

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“…Modification of lifestyle and dietary habits in relation to working activity could contribute to the shifting in gender difference of stone formation. Dietary factors promoting stone formation such as high animal protein, high salt and low calcium diets are more usual in men than in women, although the expansion of the high protein diet or higher fructose intake and low fluid intake to females could be a further cause of changing in gender of nephrolithiasis (36,37). Obesity has also been associated with increased stone show that overweight among females increases the risk for stone disease with respect to men with the same characteristics.…”

Section: Gender and Nephrolithiasismentioning

confidence: 99%

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Cicerello

Ciaccia

Cova

et al. 2021

Arch Ital Urol Androl

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Nephrolithiasis has been increasing over the last millennium. Although early epidemiologic studies have shown that kidney stones were two to three times more frequent in males than in females, recent reports have suggested that this rate is decreasing. In parallel a dramatic increase of nephrolithiasis has also been observed among children and adolescents. Furthermore, epidemiologic studies have shown a strong association between metabolic syndrome (Mets) traits and kidney stone disease. Patients with hypertension have a higher risk of stone formation and stone formers are predisposed to develop hypertension compared to the general population. An incidence of nephrolithiasis greater than 75% has been shown in overweight and obese patients compared to those of normal weight. It has also been reported that a previous diagnosis of diabetes mellitus increases the risk of future nephrolithiasis. Additionally, an association between metabolic syndrome and uric acid stone formation has been clearly recognized. Furthermore, 24-h urinary metabolic abnormalities have been decreasing among patients with nephrolithiasis over the last decades. Finally, nephrolithiasis could cause chronic kidney disease (CKD) and end stage renal disease (ESRD), especially in women and overweight patients. According to these observations, a better understanding of these new features among stone former patients may be required. Hence, the recognition and the correction of metabolic disorders could help not only to reduce the primary disease, but also stone recurrence.

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Section: Gender and Nephrolithiasismentioning

confidence: 99%

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Cicerello

Ciaccia

Cova

et al. 2021

Arch Ital Urol Androl

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“…8 Finally, a further cross-section analysis of NHANES data from 2007 to 2012, where the self-start stone disease prevalence was based on gender, found equal findings of stone prevalence of approximately 1/16 in both male and female young adults aged less 50 years. 9 Besides, the Rochester Epidemiology Project has reported long-term data on the prevalence of stone disease on the population of Rochester, in Minnesota between 1950 and 1974. In this study the annual incidence rate in relation to the average age of the first kidney stones remained stable in women at 36 per 100,000 population, but increased significantly in men from 79 per 100,000 to 124 per 100,000 population.…”

Section: Epidemiology and Gendermentioning

confidence: 99%

“…the widespread of high protein diet or higher fructose intake) in females could be an additional potential cause of speedy changing in gender ratio. 9,10,16 Another factor in changing gender of nephrolithiasis is the disproportionate increase of obesity among females. The NHANES surveys from 1960 to 1980 showed very few changes in obesity both in males and females, but that an that runs between 1980 and 2000 observed an increased equally among men and women.…”

Section: Commentmentioning

confidence: 99%

Changing in gender prevalence of nephrolithiasis

et al. 2020

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Although nephrolithiasis is a more common disease in men rather than women, several studies over the last decades show that the male to female ratio 3:1 is narrowing. These finding may be associated to modified risk factors for stone formation between females and males. Changes in lifestyle and increasing obesity in women may play a role in shifting of gender disparity. Furthermore, recent studies have demonstrated an increase of kidney stones in women which have necessitated emergency department visits (ED). Therefore, females show a greater percentage of mortality rate if compared to males, especially if stone disease is associated to urosepsis and requires the admission to the Intensive Care Unit (ICU). This article reviews recent insights into changing gender prevalence in urinary calculi and into identifying the relation between gender and risk factors for stone disease, that in case of severe urosepsis might also lead to mortality.

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“…Severe cases may be combined with long-term, chronic obstructive hydronephrosis, eventually causing varying degrees of kidney function damage, and even endangering the lives of patients. There are many types of urinary stones, and the pathogenesis involves the combined effects of abnormal human metabolism, urinary tract obstruction, infection, drugs, and a variety of internal and external environmental factors (such as age, gender, race, genetics, geography, climate, water intake, and dietary habits) (3)(4)(5). Calculi composition is closely related to the choice of treatment and preventive measures.…”

Section: Introductionmentioning

confidence: 99%

Value of artificial intelligence model based on unenhanced computed tomography of urinary tract for preoperative prediction of calcium oxalate monohydrate stones in vivo

Tang¹,

Li²,

Zeng³

et al. 2021

Ann Transl Med

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Background: Urolithiasis is a global disease with a high incidence and recurrence rate, and stone composition is closely related to the choice of treatment and preventive measures. Calcium oxalate monohydrate (COM) is the most common in clinical practice, which is hard and difficult to fragment.Preoperative identification of its components and selection of effective surgical methods can reduce the risk of patients having a second operation. Methods that can be used for stone composition analysis include infrared spectroscopy, X-ray diffraction, and polarized light microscopy, but they are all performed on stone specimens in vitro after surgery. This study aimed to design and develop an artificial intelligence (AI) model based on unenhanced computed tomography (CT) images of the urinary tract, and to investigate the predictive ability of the model for COM stones in vivo preoperatively, so as to provide surgeons with more accurate diagnostic information.Methods: Preoperative unenhanced CT images of patients with urinary calculi whose components were determined by infrared spectroscopy in a single center were retrospectively analyzed, including 337 cases of COM stones and 170 of non-COM stones. All images were manually segmented and the image features were extracted, and randomly divided into the training and testing sets in a ratio of 7:3. The least absolute shrinkage and selection operation algorithm (LASSO) was used to construct the AI model, and classification of the training and testing sets was carried out.Results: A total of 1,218 radiomics imaging features were extracted, and 8 features with non-zero coefficients were finally obtained. The sensitivity, specificity and accuracy of the AI model were 90.5%, 84.3% and 88.5% for the training set, and 90.1%, 84.3% and 88.3% for the testing set. The area under the curve was 0.935 for the training set and 0.933 for the testing set. Conclusions:The AI model based on unenhanced CT images of the urinary tract can predict COM and non-COM stones in vivo preoperatively, and the model has high sensitivity, specificity and accuracy.

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Gender Equivalence in the Prevalence of Nephrolithiasis among Adults Younger than 50 Years in the United States

Cited by 28 publications

References 15 publications

The new patterns of nephrolithiasis: What has been changing in the last millennium?

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Changing in gender prevalence of nephrolithiasis

Value of artificial intelligence model based on unenhanced computed tomography of urinary tract for preoperative prediction of calcium oxalate monohydrate stones in vivo

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