Changing in gender prevalence of nephrolithiasis

Cicerello, E.; Mangano, M.; Cova, Giandavide; Ciaccia, Matteo

doi:10.1177/0391560320966206

Cited by 22 publications

(18 citation statements)

References 31 publications

(36 reference statements)

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“…Modification of lifestyle and dietary habits in relation to working activity could contribute to the shifting in gender difference of stone formation. Dietary factors promoting stone formation such as high animal protein, high salt and low calcium diets are more usual in men than in women, although the expansion of the high protein diet or higher fructose intake and low fluid intake to females could be a further cause of changing in gender of nephrolithiasis (36,37). Obesity has also been associated with increased stone show that overweight among females increases the risk for stone disease with respect to men with the same characteristics.…”

Section: Gender and Nephrolithiasismentioning

confidence: 99%

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Cicerello

Ciaccia

Cova

et al. 2021

Arch Ital Urol Androl

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Nephrolithiasis has been increasing over the last millennium. Although early epidemiologic studies have shown that kidney stones were two to three times more frequent in males than in females, recent reports have suggested that this rate is decreasing. In parallel a dramatic increase of nephrolithiasis has also been observed among children and adolescents. Furthermore, epidemiologic studies have shown a strong association between metabolic syndrome (Mets) traits and kidney stone disease. Patients with hypertension have a higher risk of stone formation and stone formers are predisposed to develop hypertension compared to the general population. An incidence of nephrolithiasis greater than 75% has been shown in overweight and obese patients compared to those of normal weight. It has also been reported that a previous diagnosis of diabetes mellitus increases the risk of future nephrolithiasis. Additionally, an association between metabolic syndrome and uric acid stone formation has been clearly recognized. Furthermore, 24-h urinary metabolic abnormalities have been decreasing among patients with nephrolithiasis over the last decades. Finally, nephrolithiasis could cause chronic kidney disease (CKD) and end stage renal disease (ESRD), especially in women and overweight patients. According to these observations, a better understanding of these new features among stone former patients may be required. Hence, the recognition and the correction of metabolic disorders could help not only to reduce the primary disease, but also stone recurrence.

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Section: Gender and Nephrolithiasismentioning

confidence: 99%

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Cicerello

Ciaccia

Cova

et al. 2021

Arch Ital Urol Androl

Self Cite

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“…The prevalence of nephrolithiasis was expected to be about 13% in North America, 5–9% in Europe, and 1–5% in Asia [ 3 ]. The prevalence of nephrolithiasis has been higher in men than women, with a men-to-women ratio of 3:1 [ 4 , 5 ]. The reasons for the rising incidence of nephrolithiasis have been attributed to several lifestyle factors, such as obesity and dietary habits of calcium and fluid intake [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Obesity Is Positively Associated and Alcohol Intake Is Negatively Associated with Nephrolithiasis

et al. 2022

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The current research investigated the impacts of smoking, alcohol consumption, and obesity on the development of nephrolithiasis. We included ≥40-year-old Koreans from the Korean National Health Insurance Service-Health Screening Cohort. A total of 28,395 nephrolithiasis patients were compared with 113,580 control participants. Previous histories of smoking, alcohol consumption, and obesity were examined before the presence of nephrolithiasis. Conditional logistic regression analysis was performed to estimate the odds ratios (ORs) of smoking, alcohol consumption, and obesity for nephrolithiasis. Further analyses were conducted, according to age, sex, smoking, alcohol consumption, and obesity. The current smoking status was not linked with the presence of nephrolithiasis. Alcohol consumption was linked with a lower likelihood of the presence of nephrolithiasis (adjusted OR (aOR) = 0.89, 95% confidence intervals (CI) = 0.86–0.92, p < 0.001). Being obese was associated with a greater likelihood of the presence of nephrolithiasis ((95% CI) = 1.27 (1.22–1.31) < 1.42 (1.37–1.46) < 1.59 (1.47–1.71) for overweight < obese I < obese II). The relation of alcohol consumption and obesity with nephrolithiasis was consistent in the subgroups. The presence of nephrolithiasis was positively linked with obesity and negatively linked with alcohol consumption.

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“…For instance, the burden of nephrolithiasis was 10.6% in the United States [ 1 ], 6.2%– 9.1% in Saudi Arabia [ 5 , 6 ], 6.4% in China [ 2 ] and 7.9% in India [ 7 ]. Although this disease is more common in males than females in a ratio of 3:1, there is a declining trend of male predominance [ 8 ]. Stone recurrence is common.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risk factors, ethnicity and infection stone are independent factors associated with reduced renal function in renal stone formers

et al. 2022

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Background Recent evidence suggested the link between nephrolithiasis and renal function impairment. We aimed to determine the renal function profile and potential factors associated with reduced renal function amongst renal stone formers in multi-ethnic Asians. Methods We conducted a cross-sectional study involving patients undergoing percutaneous nephrolithotomy between May 2015 and December 2019. Reduced renal function was defined as having estimated glomerular filtration rate < 60 ml/min per 1.73 m2. Renal stone samples were collected and quantified using infrared spectroscopy. Potential factors associated with reduced renal function including age, ethnicity, educational level, history of diabetes, hypertension, gout, hydronephrosis, serum uric acid level, and type of renal stone were evaluated using univariable and multivariable analyses. Results A total of 1162 patients from a multi-ethnic population (Malays 67%, Chinese 19%, Indians 13% and indigenous people 1%) with median age of 57 years (Interquartile range 48–64) were enrolled in the study. Almost a third of patients were found with reduced renal function. Multivariable analysis showed that the odds of having reduced renal function increased with age, ethnicity, lower educational level, history of diabetes, hypertension, gout, bilateral hydronephrosis, elevated serum uric acid level and infection stone. Conclusions Reduced renal function varies between ethnicities and all age groups of renal stone formers. In addition to age and ethnicity, cardiovascular risk factors including diabetes and hypertension may also need to be taken into account in managing stone patients with reduced renal function.

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Changing in gender prevalence of nephrolithiasis

Cited by 22 publications

References 31 publications

The new patterns of nephrolithiasis: What has been changing in the last millennium?

The new patterns of nephrolithiasis: What has been changing in the last millennium?

Obesity Is Positively Associated and Alcohol Intake Is Negatively Associated with Nephrolithiasis

Cardiovascular risk factors, ethnicity and infection stone are independent factors associated with reduced renal function in renal stone formers

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