Gender, Environmental Tobacco Smoke, and Pulmonary Function in Rural Children and Adolescents: The Humboldt Study

Chen, Yue; Rennie, Donna; Lockinger, Lori A.; Dosman, JA

doi:10.13031/2013.18183

Cited by 26 publications

(15 citation statements)

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“…Because it has been shown that asthma symptoms are exacerbated by ETS exposure (31, 32), it is reasonable that there is a significant association between ETS exposure and decreased asthma control in this cluster.…”

Section: Discussionmentioning

confidence: 95%

Overcoming Heterogeneity in Pediatric Asthma: Tobacco Smoke and Asthma Characteristics Within Phenotypic Clusters in an African American Cohort

et al. 2010

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Objective Asthma in children and adolescents is a heterogeneous syndrome comprised of multiple subgroups with variable disease expression and response to environmental exposures. The goal of this study was to define homogeneous phenotypic clusters within a cohort of children and adolescents with asthma and to determine overall and within-cluster associations between environmental tobacco smoke (ETS) exposure and asthma characteristics. Methods A combined hierarchical/k-means cluster analysis of principal component variables was used to define phenotypic clusters within a cohort of 6 to 20 year-old urban and largely minority subjects. Results Among the 154 subjects, phenotypic cluster analysis defined three independent clusters (Cluster 1 [n=57]; Cluster 2 [n=33]; Cluster 3 [n=58]). A small fourth cluster (n=6) was excluded. Patients in Cluster 1 were predominantly males with a relative abundance of neutrophils in their nasal washes. Patients in Cluster 2 were predominantly females with high body mass index percentiles and later-onset asthma. Patients in Cluster 3 had higher eosinophil counts in their nasal washes and lower Asthma Control Test™ (ACT) scores. Within-cluster regression analysis revealed several significant associations between ETS exposure and phenotypic characteristics that were not present in the overall cohort. ETS exposure was associated with a significant increase in nasal wash neutrophils (Beta Coefficient = 0.73 [95%CI: 0.11 to 1.35]; P=0.023) and a significant decrease in ACT score (−5.17 [−8.42 to −1.93]; P=0.003) within Cluster 1 and a significant reduction in the bronchodilator-induced % change in FEV1 (−36.32 [−62.18 to −10.46]; P=0.009) within Cluster 3. Conclusions Clustering techniques defined more homogeneous subgroups allowing for the detection of otherwise undetectable associations between environmental tobacco smoke exposure and asthma characteristics.

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Section: Discussionmentioning

confidence: 95%

Overcoming Heterogeneity in Pediatric Asthma: Tobacco Smoke and Asthma Characteristics Within Phenotypic Clusters in an African American Cohort

et al. 2010

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“…mold/water damage in the household, house decoration, and ETS) than girls. There is some evidence that the airways of men and women respond differently to exposure to environmental factors (Holmen et al 2002;Jaakkola et al 2002;Chen et al 2005). This is plausible as there are differences between the male and female airways from early in fetal lung development and throughout life (Becklake and Kauffmann 1999).…”

Section: Discussionmentioning

confidence: 99%

Housing characteristics, home environmental factors and respiratory health in 3945 pre-school children in China

Dong

Ding

et al. 2008

International Journal of Environmental Health Research

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The objective of the study was to assess the effects of housing characteristics and home environmental factors on respiratory symptoms of Chinese children. A cross-sectional study of 3945 children aged 1-6-years-old was conducted at 24 randomly selected kindergartens in Liaoning province, northeast China during April 2007. Information on respiratory symptoms (persistent cough, persistent phlegm, doctor-diagnosed asthma, current asthma, current wheeze and allergic rhinitis) and exposures to home environmental factors was obtained by a standard questionnaire from the American Thoracic Society. We used Chi-square tests, multivariate logistic regression models and adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for estimates of the risk of respiratory symptoms. Results suggested that the prevalence of asthma-related symptoms was higher for those who lived along the main stem of traffic, and houses near a pollution source. Lower prevalence rates of respiratory morbidity were associated with households with a larger area of residence and more rooms. Pet keeping was associated with doctor-diagnosed asthma (OR = 1.45; 95% CI, 1.03-2.06). Among boys, home decorations significantly increased the risk of doctor-diagnosed asthma (OR = 1.71; 95% CI, 1.21-2.41), current asthma (OR = 1.80; 95% CI, 1.10-2.94) and current wheeze (OR = 1.81; 95% CI, 1.31-2.50). Environmental tobacco smoke, pests and visible mold on walls were associated with the occurrence of asthma symptoms, especially in boys. Based upon the findings of this study, it is concluded that home environmental factors are particularly important for the development of respiratory morbidity among children. Boys may be more susceptible to home environmental factors than girls.

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“…There is a growing body of evidence that suggests that female smokers may be at a higher risk for tobacco-related loss in pulmonary function than men (67)(68)(69)(70)(71)(72). Similar to the data described with tobacco exposure and bronchial hyperresponsiveness, the accelerated effects of tobacco exposure on lung function in females can be seen in children and adolescents.…”

Section: Effects Of Tobaccomentioning

confidence: 99%

“…Similar to the data described with tobacco exposure and bronchial hyperresponsiveness, the accelerated effects of tobacco exposure on lung function in females can be seen in children and adolescents. During childhood, girls experience a larger reduction in lung function when exposed to environmental tobacco smoke compared with boys (67,71). A longitudinal study of 10,060 adolescents suggested that girls may be more vulnerable than boys to the effects of smoking on growth of lung function (69).…”

Section: Effects Of Tobaccomentioning

confidence: 99%

“…Some authors have shown that the effects of obesity on asthma are significant only in women (67,74,81,82) while others have demonstrated a stronger association between obesity and asthma in men (83,84). In a recent meta-analysis of prospective series evaluating body mass index (BMI) and the incidence of asthma, Beuther and Sutherland (85) concluded that increasing BMI, in a dose-dependent fashion, was associated with an increased incidence of asthma in both men and women.…”

Section: Obesitymentioning

confidence: 99%

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Sex Differences in Asthma

McCallister

Mastronarde

2008

Journal of Asthma

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Asthma is a common chronic pulmonary disease whose prevalence varies greatly with the sex and age of the patient. Research has shown that men and women may experience this disease differently, although these sex-related differences have not routinely translated into differences in clinical care for patients with asthma. This review explores some of the major differences in asthma between men and women and some of the main hypotheses developed to explain them.

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Gender, Environmental Tobacco Smoke, and Pulmonary Function in Rural Children and Adolescents: The Humboldt Study

Cited by 26 publications

References 0 publications

Overcoming Heterogeneity in Pediatric Asthma: Tobacco Smoke and Asthma Characteristics Within Phenotypic Clusters in an African American Cohort

Overcoming Heterogeneity in Pediatric Asthma: Tobacco Smoke and Asthma Characteristics Within Phenotypic Clusters in an African American Cohort

Housing characteristics, home environmental factors and respiratory health in 3945 pre-school children in China

Sex Differences in Asthma

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