Gender disparity in ventilator-associated pneumonia following trauma

Sharpe, John P.; Magnotti, Louis J.; Weinberg, Jordan A.; Brocker, Jason; Schroeppel, Thomas J.; Zarzaur, Ben L.; Fabian, Timothy C.; Croce, Martin A.

doi:10.1097/ta.0000000000000251

Cited by 47 publications

(49 citation statements)

References 21 publications

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“…In our population, mortality was higher in the elderly subgroup (age ≥ 60 years) as shown in Table 3 and is consistent with recent reports [18]. As per our observation, females developed less VAP but experienced increased mortality (42.9% versus 18.8%, p = 0.02) and this confirms the results from previous studies [19]. Resende and coworkers have emphasized on the fact that the presence of comorbidities has significant impact on the outcome of patients with VAP [8].…”

Section: Discussionsupporting

confidence: 93%

Epidemiology and Outcome of Ventilator-Associated Pneumonia in a Heterogeneous ICU Population in Qatar

Ali

Khan

George

et al. 2016

BioMed Research International

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Objective. The purpose of this study is to collect data on epidemiology, microbiology, and outcome of VAP in our ICUs for reevaluation of the therapeutic strategies. Methods. This retrospective study involved all adult patients, 15 years of age or older, diagnosed with VAP in multidisciplinary ICUs at Hamad General Hospital between January 2010 and December 2012. Results. A total of 106 patients were enrolled. The mean incidence of VAP was 5.0 per 1000 ventilator-days. It was predominant among younger age group (<60 years), male patients (80.2%), and trauma ICU admissions (49.0%). The most common comorbidity was hypertension (34%) and polytrauma (36.8%) was the most frequent admission diagnosis. 30-day mortality was 23.6% and it was significantly higher in ≥60 years age group, female gender, patients with diabetes mellitus, hypertension, chronic respiratory disease, ≥1 comorbidity, and poor functional status, smokers, medical and surgical ICU admissions, and patients with previous stay in medical/surgical wards, inappropriate empirical therapy, and admission diagnosis of respiratory failure. Gram-negative bacilli were the most frequent respiratory specimen isolates, Pseudomonas spp. being the most common. Majority of our Acinetobacter isolates were multidrug resistant. Conclusion. The incidence of VAP in our ICUs was low. Higher mortality rates were observed in certain subgroup of patients. Resistance to commonly used antimicrobials is likely to require reevaluation of the therapeutic strategies at our institution.

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Section: Discussionsupporting

confidence: 93%

Epidemiology and Outcome of Ventilator-Associated Pneumonia in a Heterogeneous ICU Population in Qatar

Ali

Khan

George

et al. 2016

BioMed Research International

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“…In the present study, VAE was more common in men (67.6%) than in women (32.4%); this may be explained by the high prevalence of COPD and cardiac impairment among men than women, and these two diseases were the most commonly recorded causes of ICU admission and for MV. These findings were in agreement with those of Sharpeet al [25], who found that VAE was common in men (79%) than women (21%) among ventilated patients because of trauma. Also, Goel et al [26] recorded a higher incidence of VAE in their study in men than women (69.81 vs. 30.19%).…”

Section: Care Of Airway Equipmentsupporting

confidence: 93%

Incidence, microbiological profile and outcome of ventilator-associated events in a tertiary care hospital in Bangalore, Karnataka, India

N¹,

Manasa²,

Hedge³

et al. 2020

Trop J Pathol Microbiol

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Introduction: Despite different ICU admission causes, ventilator-associated event (VAE) is still a common cause of mortality and morbidity in intubated patients and impedes obvious progression in diagnostic modalities and management of these infections. Objectives: The aim of this study was to estimate VAE incidence, detection of antimicrobial resistance pattern's which can help in the management and to follow the outcome of the patients having VAE. Materials and methods: This was a retrospective study done over a period of 24months from January 2018 to December 2019 in a tertiary care hospital in Bangalore. The study population included all the confirmed VAE patients. Their incidence of microbiological profile and the outcome was noted. Results: Out of 422 mechanical ventilated (MV) patients 71 patients developed VAE. In the 71 proved VAE cases 48 (67.6%) were male and23 (32.4%) were females. Out of 71 cases, the mean age who were having VAE falls in the range of 65-75 yrs. The incidence of VAE is 16.82 and the incidence density:9.78 /1000 ventilator days. Klebsiella pneumonia (29.5%) was the common organism isolated among 71 cases. Conclusion: Utilizing the preventive, diagnostic, and treatment recommendations outlined should allow for improved outcomes for a common and serious medical complication seen in ICU mechanically ventilated patients.

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“…37%. [25] The mortality rate in our study was about 30%, which is similar to other studies. [26] Our study also supports the observation that elderly population are at more risk of death due to VAP i.e.…”

Section: Discussionsupporting

confidence: 82%