Gender differences in the relation between social support, problems in parent-offspring communication, and depression and anxiety

Landman-Peeters, Karlien; Hartman, Catharina A.; Pompe, Gieta Van Der; Boer, Johan A. den; Minderaa, Ruud B.; Ormel, Johan

doi:10.1016/j.socscimed.2004.10.024

Cited by 136 publications

(88 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study design of ARIADNE has been described previously [Landman-Peeters et al, 2005]. Briefly, patients with (a) at least one treated episode of emotional disorder between 1990 and 2002, (b) no personal history of schizophrenia spectrum diagnoses, and (c) biological children aged 13-25 years were identified through 16 psychiatric services in the three northern provinces of the Netherlands.…”

Section: Participantsmentioning

confidence: 99%

Risk of emotional disorder in offspring of depressed parents: gender differences in the effect of a second emotionally affected parent

et al. 2008

Self Cite

View full text Add to dashboard Cite

In offspring of depressed parents a second parent with emotional problems is likely to increase risk of emotional disorder. This effect may however differ between sons and daughters and between offspring of depressed fathers and offspring of depressed mothers. In adolescent and young-adult offspring of parents with major depressive disorder, this study examined the effects of a second affected parent, offspring gender, gender of the depressed parent and their interactions on risk of depression and anxiety disorder. We found that daughters had a higher risk of depression and anxiety than sons and that offspring of depressed mothers had a higher risk of anxiety than offspring of depressed fathers. In addition to these main effects, we found an interaction between parent and offspring gender inasmuch that sons of depressed fathers had the lowest risk of depression and anxiety relative to the other groups. A second affected parent tended to increase risk of depression and significantly increased risk of anxiety. However, this effect of a second affected parent on offspring anxiety was most prominent in daughters when the second affected parent was the father, whereas risk in sons did not increase if the father was affected as well. Our results indicate that paternal and maternal depression similarly and additively increase daughters' risk of emotional disorder, but that sons' risk only increases with maternal depression. Intergenerational transmission of emotional disorder seems strongest when the female gender is involved, either in the form of a daughter or a depressed mother.

show abstract

Section: Participantsmentioning

confidence: 99%

Risk of emotional disorder in offspring of depressed parents: gender differences in the effect of a second emotionally affected parent

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…21,22,23 Methods Participants Participants in this study were recruited from local and regional sources (North Netherlands Population Registration) as volunteers for the Neurobiological and Epidemiological cohort-study of Adolescents at Risk of Anxiety and Depression (ARIADNE). 23,24 For the psychological stress challenge, 70 participants took part in the laboratory stress challenge (see Supplementary Table S1). For the dex/CRH challenge, 64 individuals were included, a majority of whom were tested in the stress challenge (see Supplementary Table S2).…”

Section: Introductionmentioning

confidence: 99%

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA

et al. 2007

View full text Add to dashboard Cite

Highly prevalent stress-related disorders such as major depression (MD) are characterised by a dysregulation of the neuroendocrine system. Although heritability for these disorders is high, the role of genes in the underlying pathophysiology is poorly understood. Here, we show that polymorphic variations in genes coding for serotonin transporter (5-HTT), catechol-Omethyl transferase (COMT) and monoamine oxidase A (MAOA) as well as sex differences influence the regulation of hypothalamic-pituitary-adrenal (HPA)-axis response to acute psychological and endocrine challenges. In our sample, the effects of COMT on the release of adrenocorticotrophin hormone (ACTH) depend on the presence of the low-expression MAOA variant in the same individual. By including individuals varying in their degree of susceptibility to MD, we showed evidence of interactions between 5-HTT and MD susceptibility in baseline cortisol, and between MAOA and MD susceptibility in baseline ACTH measures, indicating a role for these genotypes in stable-state endocrine regulation. Collectively, these results indicate that the simultaneous investigation of multiple monoaminergic genes in interaction with gender have to be measured to understand the endocrine regulation of stress. These findings point towards a genetic susceptibility to stress-related disorders.

show abstract

“…The second cohort exists of participants of the Adolescents at Risk for Anxiety and Depression (ARIADNE) study (Landman-Peeters et al, 2005), a prospective cohort study among 528 biological children (aged 13-25 years) of parents who were treated for depressive or anxiety disorder as outpatient at a mental health organization. These children can be considered at high risk to develop depressive or anxiety disorders themselves.…”

Section: Samplingmentioning

confidence: 99%

The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods

Penninx

Beekman

Smit

et al. 2008

Int J Methods Psych Res

Self Cite

840

737

View full text Add to dashboard Cite

show abstract

Gender differences in the relation between social support, problems in parent-offspring communication, and depression and anxiety

Cited by 136 publications

References 38 publications

Risk of emotional disorder in offspring of depressed parents: gender differences in the effect of a second emotionally affected parent

Risk of emotional disorder in offspring of depressed parents: gender differences in the effect of a second emotionally affected parent

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA

The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods

Contact Info

Product

Resources

About