Gender differences in the microbial spectrum and antibiotic sensitivity of uropathogens isolated from patients with urinary stones

Gu, Jie; Chen, Xiong; Yang, Zhiming; Bai, Yao; Zhang, Xiaobo

doi:10.1002/jcla.24155

“…In our study, multivariate analysis revealed that male gender, <19 months, weight < 11:5 (kg), height < 83 (cm), BMI < 17:09, BUN > 4:08 (mmol/L), and internal drainage were risk factors of postoperative UTI in pediatric UPJO patients, suggesting that younger boys with lower weight or height, lower BMI, higher BUN, or internal drainage may require more attention regarding postoperative UTI. A previous study demonstrated that uropathogens isolated from male urolithiasis patients were more resistant to antimicrobials than female, revealing the presence of sex differences with regard to microbial spectrum and antibiotic sensitivity [18]. Consistent with our study, gender difference was also observed in patients with UTI after retrograde upper urinary lithotripsy [19].…”

Section: Discussionsupporting

confidence: 91%

Risk Factors of Urinary Tract Infection in Pediatric Patients with Ureteropelvic Junction Obstruction after Primary Unilateral Pyeloplasty

Wang

¹

,

Hao

²

,

Bai

³

2022

Computational and Mathematical Methods in Medicine

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Objective. Ureteropelvic junction obstruction (UPJO) represents to a leading cause of fetal hydronephrosis, which is associated with urinary tract infection (UTI) and urinary stone disease. This study is aimed at investigating risk factors of UTI in pediatric patients with UPJO after primary unilateral pyeloplasty. Methods. The records of a consecutive series of patients undergoing primary pyeloplasty at a single institution between June 2015 and November 2021 were retrospectively reviewed. Demographic and clinical characteristics, including age, gender, weight, height, body mass index (BMI), creatinine (Cr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), neutrophil ratio, lymphocyte ratio, neutrophil/lymphocyte ratio, renal pelvis anteroposterior diameter (APD), renal cortex thickness, caliectasis, open or laparoscopic pyeloplasty, and internal drainage or external drainage, were collected and analyzed. The incidence of postoperative UTI and its risk factors was analyzed. Results. A total of 504 patients were enrolled in the study, and they were classified into the UTI group ( n = 188 ) and non-UTI group ( n = 361 ). Univariate analysis of the incidence of UTI revealed that age, gender, weight, height, BMI, surgical modality, Cr level, BUN level, neutrophil ratio, lymphocyte ratio and neutrophil/lymphocyte ratio, renal cortex thickness, and postoperative drainage modality were associated with UTI incidence after pyeloplasty in pediatric patients with UPJO. Multivariate analysis revealed that male gender, <19 months, weight < 11.5 (kg), height < 83 (cm), BMI < 17.09 , BUN > 4.08 (mmol/L), and internal drainage were risk factors of postoperative UTI in pediatric patients with UPJO. Conclusion. Our study demonstrated that male gender, <19 months, weight < 11.5 (kg), height < 83 (cm), BMI < 17.09 , BUN > 4.08 (mmol/L), and internal drainage were risk factors of UTI in pediatric patients with UPJO after primary unilateral pyeloplasty, which may provide reference for prophylactic antibiotics for those patients with risk factors.

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“…Higher rates of urinary tract infections with Escherichia coli, Staphylococcus aureus, Enterobacter, and Klebsiella Pneumonia were detected among females compared to males, while only Escherichia coli and Staphylococcus aureus were more prevalent among urinary stones female patients in another study [43].…”

Section: Discussionmentioning

confidence: 79%

“…The relation between gender and antibiotic resistance was also noted in other studies. For example, higher susceptibility rates of Escherichia coli isolates to piperacillin-tazobactam, and imipenem were also associated with female gender, while nitrofurantoin susceptibility was not associated with gender [44]. On the other hand, in Bangladesh, Escherichia coli strains in male patients were more resistant to amikacin, colistin, and nitrofurantoin [45].…”

Section: Discussionmentioning

confidence: 97%

Antibiotic sensitivity pattern of bacterial pathogens in two tertiary care hospitals in Damascus, Syria: A cross-sectional study

Abdelwahed¹,

Jassem²,

Kakaje

³

et al. 2022

Preprint

0

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Background Antibiotics resistance is a major concern as it renders antibiotics ineffective, which would have disastrous effects on patient care. The contribution of the Middle Eastern countries in limiting antimicrobial resistance is diminished due to instability and deteriorating healthcare infrastructure. This study aims to report on the antimicrobial resistance pattern in two tertiary care hospitals in Damascus, the capital of Syria in bloods, sputum, urine and others. Methods A cross-sectional study based on reports of bacterial cultures was performed between April and November in 2020 in microbiology labs of Damascus Hospital and Al-Razi Hospital. Identification of bacteria was performed using standard microbiological procedures. Susceptibility testing was performed using disk diffusion method. Interpretation of the results was done according to the guidelines of the Clinical and Laboratory Standard Institute. Data were analyzed using the statistical package for social sciences version 26. Results 412 cultures were positive for pathogens. Most frequently isolated pathogens were Enterobacter, Staphylococcus aureus, and Escherichia coli. Enterobacter was completely sensitive to doripenem and cefoperazone-sulbactam. The resistance rates of Staphylococcus aureus to vancomycin and linezolid were 23.5% and 24.5%, respectively. Escherichia coli was resistant to ciprofloxacin in 72.4% of samples. Klebsiella pneumonia had shown various resistance rates to all used antibiotics. Females had significantly higher frequency of Escherichia coli, Enterobacter, and Klebsiella pneumoniae in urine samples, while males had significantly higher frequency of Pseudomonas aeruginosa and Proteus mirabilis. Conclusions This study highlighted the high prevalence of antimicrobial resistance in Damascus Hospital and Al-Razi Hospital, two of major hospitals in Damascus. The decreasing potency of antimicrobials is concerning and may require urgent interventions, such as effective surveillance, development of national guidelines for prescribing antibiotics to treat common infections, and awareness campaigns in the community.

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“…Higher rates of urinary tract infections with Escherichia coli, Staphylococcus aureus, Enterobacter, and Klebsiella Pneumonia were detected among females compared to males, while only Escherichia coli and Staphylococcus aureus were more prevalent among urinary stones female patients in another study [43]. Urine isolates in males were more resistant to imipenem, nitrofurantoin, amoxicillin-clavulanic, piperacillin-tazobactam, and cefaclor.…”

Section: Discussionmentioning

confidence: 85%

Antibiotic sensitivity pattern of bacterial pathogens in two tertiary care hospitals in Damascus, Syria: A cross-sectional study

Abdelwahed¹,

Jassem²,

Kakaje

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Antibiotics resistance is a major concern as it renders antibiotics ineffective, which would have disastrous effects on patient care. The contribution of the Middle Eastern countries in limiting antimicrobial resistance is diminished due to instability and deteriorating healthcare infrastructure. This study aims to report on the antimicrobial resistance pattern in two tertiary care hospitals in Damascus, the capital of Syria in samples of blood, sputum, urine and other. A cross-sectional study based on reports of bacterial cultures was performed between April and November in 2020 in microbiology labs of Damascus Hospital and Al-Razi Hospital. Identification of bacteria was performed using standard microbiological procedures. Susceptibility testing was performed using disk diffusion method. Interpretation of the results was done according to the guidelines of the Clinical and Laboratory Standard Institute. Data were analyzed using the statistical package for social sciences version 26. 412 cultures were positive for pathogens. Most frequently isolated pathogens were Enterobacter, Staphylococcus aureus, and Escherichia coli. Enterobacter was completely sensitive to doripenem and cefoperazone-sulbactam. The resistance rates of Staphylococcus aureus to vancomycin and linezolid were 23.5% and 24.5%, respectively. Escherichia coli was resistant to ciprofloxacin in 72.4% of samples. Klebsiella pneumonia had shown various resistance rates to all used antibiotics. Females had significantly higher frequency of Escherichia coli, Enterobacter, and Klebsiella pneumoniae in urine samples, while males had significantly higher frequency of Pseudomonas aeruginosa and Proteus mirabilis. This study showed the high prevalence of antimicrobial resistance in Damascus Hospital and Al-Razi Hospital, two of major hospitals in Damascus. The decreasing potency of antimicrobials is concerning and may require urgent interventions, such as effective surveillance, and development of national guidelines for prescribing antibiotics.

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Gender differences in the microbial spectrum and antibiotic sensitivity of uropathogens isolated from patients with urinary stones

Cited by 14 publications

References 26 publications

Risk Factors of Urinary Tract Infection in Pediatric Patients with Ureteropelvic Junction Obstruction after Primary Unilateral Pyeloplasty

Risk Factors of Urinary Tract Infection in Pediatric Patients with Ureteropelvic Junction Obstruction after Primary Unilateral Pyeloplasty

Antibiotic sensitivity pattern of bacterial pathogens in two tertiary care hospitals in Damascus, Syria: A cross-sectional study

Antibiotic sensitivity pattern of bacterial pathogens in two tertiary care hospitals in Damascus, Syria: A cross-sectional study

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